Application of compound isatis root preparation in preparing medicaments for preventing and controlling endotoxaemia

Abstract

The invention relates to an application of a compound isatis root preparation in preparing drugs for preventing and curing endotoxaemia. The compound isatis root preparation is composed of isatis root and dyers woad leaf. Through a plurality of evaluation experiments in pharmaco dynamics, the isatis root granules show broad anti-endotoxaemia activity in vitro and in vivo, which can directly neutralize and degrade the endotoxaemia and remarkably antagonize fever, lethality and DIC biological effect resulted from endotoxaemia. At the same time, the molecular biology experiment indicates that the preparation of the invention can inhibit the endotoxaemia to stimulate the expression of the important tissue moesin mRNA of human body and ease the rising degree of P38 MAPK. Moreover, the isatis root granules can inhibit the composition and release of endotoxaemia-induced inflammations, lower the LPO level, heighten the SOD activity, alleviate the damages of human body resulted from being attracted by free radicals, which is favorable for inhibiting inflammatory response syndromes, thus effectively controlling the state of illness and death rate.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the new application of compound isatidis granules in the preparation of drugs for preventing and treating endotoxemia. Background technique [0002] In addition to various infectious diseases, endotoxemia exists, such as severe trauma, burns, shock, major surgery and cancer radiotherapy and chemotherapy, etc. are the main causes of endotoxemia. Bacterial endotoxin (endotoxin) is the cell wall lipopolysaccharide component (lipopolysaccharide, LPS) that is released when Gram-negative bacteria grow or is cleaved when they die. After entering the body, it interacts with host cells and exhibits a wide range of biological activities. and key pathogenic factors of inflammatory response. Endotoxemia is the excessive entry of endogenous and exogenous endotoxins into the blood circulation, stimulating the body's immune cells to release a large number of cytokines, disrupting the balance of the bod...

AI Technical Summary

Problems solved by technology

[0003] Therefore, the anti-endotoxin drug treatment method for endotoxemia and multiple organ failure caused by it is one of the major research topics of domestic and foreign scholars, but no breakthrough results have been seen, and some preliminary experiments have confirmed curative effect. The drug is also in the laboratory stage and has not been widely used clinically