Application of 2', 5, 6', 7-tetrahydroxy dihydroflavonol for treating sepsis

Abstract

The invention relates to the usage of a 2',5',6',7'-tetrahydroxyflavanonol and the derivative in treating pyohemia, belonging to flavanonol compound THF, which is extracted and separated from baikal skullcap root of Chinese herbal medicine. Through experiment showing, the THF has the advantages that: the THF has direct neutralization effect and reveals better dose effect relationship; the THF also reveals better dose effect relationship upon inhibition of RAW 264.7 cells activation LPS stimulation; the THF can lower LPS level in blood of LPS blood symptom model animal in vivo; the THF also has obvious protection effect upon bacterial sepsis model mouse caused by heat-inactivation escherichia coli with lethal dose; the THF has good application prospect under the condition of lacking effective means treating pyohemia in prior study.

Description

technical field The invention relates to the use of 2', 5, 6', 7-tetrahydroxy dihydroflavonol and derivatives thereof for treating sepsis. Background technique Sepsis is an infectious agent-mediated systemic inflammatory response syndrome (systemic inflammatory response syndrome, SIRS), which is a common complication in patients with burns, trauma and infectious diseases. Epidemiological data show that there are more than 18 million sepsis cases worldwide every year, and the number of patients is increasing at a rate of 1.0% every year. Severe sepsis and septic shock are the leading causes of death in intensive care units (ICU), with a mortality rate as high as 50%-60%. LPS is the main component of the outer membrane of G-bacteria, and is an important pathogen-associated molecular pattern (pathogen-associated molecular patterns, PAMPs) mediating bacterial sepsis. After LPS enters the body, it first binds to lipopolysaccharide-binding protein (LBP). Under the action of LBP...

AI Technical Summary

Problems solved by technology

So far, there are no reports of THF and its derivatives and analogs neutralizing LPS and preparing drugs for treating sepsis

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