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Extract of rape pollen with broken wall and purification method and use thereof

A technology of broken wall pollen and purification method, applied in the directions of application, pharmaceutical formulation, drug combination, etc., to achieve the effect of strong anti-inflammatory and strong anti-prostate hyperplasia

Active Publication Date: 2009-01-21
JIANGSU KANION PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no relevant patents and reports on the extraction and enrichment of the active ingredients of the broken rapeseed pollen against benign prostatic hyperplasia

Method used

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  • Extract of rape pollen with broken wall and purification method and use thereof
  • Extract of rape pollen with broken wall and purification method and use thereof
  • Extract of rape pollen with broken wall and purification method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Preparation of Rapeseed Pollen Broken Supercritical Carbon Dioxide Extract

[0019] Commercially available rapeseed broken wall pollen (produced by Baikang Bee Industry in Xuancheng City, Anhui Province) was dried under reduced pressure at 60°C for 24 hours, then the dried broken wall pollen was dried at 40°C, the pressure of the extraction kettle was 40MPa, and the temperature of the separation kettle 1 was 35°C. , pressure 12MPa, separation kettle II temperature 25 ℃, pressure 5MPa, with pollen weight 8% heavy concentration being 95v / v% ethanol as entrainer to carry out supercritical carbon dioxide (45L / hour circulation consumption) extraction 2.0 hours, obtain supercritical Extract the fraction and collect the supercritical extract.

Embodiment 2

[0020] Embodiment 2 Preparation of Rapeseed Broken Pollen Extract of the Present Invention

[0021] The extract obtained in Example 1 is steamed until it has no alcohol smell, and the sample is mixed in a manner similar to the traditional silica gel column dry method, that is, the macroporous resin and the extract are taken in a column volume of 20-60% (v / v) Stir together evenly to make it fully adsorbed, put the mixed macroporous resin into the top of the macroporous resin column, wherein the macroporous resin is selected from polar macroporous resin DA201 (manufacturer: Tianjin Haiguang Chemical Co., Ltd.), and use 50 % (v / v) ethanol for elution, and the eluate was collected and dried.

Embodiment 3

[0022] Embodiment 3 The preparation of rape pollen extract of the present invention

[0023] The extract obtained in Example 1 was pretreated according to the method in Example 2, passed through a polar macroporous resin column NKA-II (manufacturer: Nankai University Chemical Plant), and eluted with 65% (v / v) ethanol , collect the eluate, and dry.

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Abstract

The present invention discloses a purification method of rape broken pollen and a prepared extract. The purification method includes using macroporous resin to accumulate the extract of rape broken pollen extracted by supercritical carbon dioxide, adopting ethanol for elution and collecting the eluent. The present invention is simple in the method and easy in operation. The extracted effective components have good anti-inflammatory activity and efficacy of resisting prostatic hyperplasia, prostatic fibrosis and other prostatic diseases.

Description

technical field [0001] The invention relates to an extract of broken wall pollen of rapeseed and its purification method and application. Background technique [0002] Rapeseed pollen is the male reproductive cell of the cruciferous plant rape (Bassica Campestros L.), which is rich in nutritional and medicinal ingredients, rich in various proteins and polypeptides, free amino acids, carbohydrates, lipids, various vitamins, constant And trace elements and other active substances, known as "concentrated miniature natural medicine" in the world. [0003] A large number of pharmacological and clinical data show that rape pollen and its crude extract have good preventive and therapeutic effects on prostate-related diseases. According to the clinical data reported by Zhejiang Institute of Geriatrics, rape pollen was used to treat 100 cases of benign prostatic hyperplasia, the effective rate of symptoms was 93%, the effective rate of residual urine was 73.2%, and the total effecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61P13/08A23L1/30A61K133/00A23L33/105
Inventor 杨义芳李坤李永辉
Owner JIANGSU KANION PHARMA CO LTD
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