Pharmaceutical composition for improving safety of Shenmai injection and method for preparing same

Abstract

The invention discloses a pharmaceutical composition for improving the safety of Shenmai injection and a method for preparing the same. The pharmaceutical composition is a pharmaceutical composition fThe invention discloses a pharmaceutical composition for improving the safety of Shenmai injection and a method for preparing the same. The pharmaceutical composition is a pharmaceutical composition fposition is reduced, and the safety for clinical application is improved.al composition is reduced, and the safety for clinical application is improved.or injection and is mainly prepared from red ginseng extract, dwarf lilyturf root extract and polyethylene glycol 12-hydroxy stearic acid ester. The pharmaceutical composition adopts a latent solventor injection and is mainly prepared from red ginseng extract, dwarf lilyturf root extract and polyethylene glycol 12-hydroxy stearic acid ester. The pharmaceutical composition adopts a latent solventwith better safety and more obvious hydrotropy to replace the latent solvent polysorbate-80 which has potential safety hazard and influences the product quality, thus the reduction of the pH value ofwith better safety and more obvious hydrotropy to replace the latent solvent polysorbate-80 which has potential safety hazard and influences the product quality, thus the reduction of the pH value ofthe Shenmai injection in the processes of storing and high temperature sterilization is obviously delayed, and the stability of the pharmaceutical composition is increased; besides, the safety of thethe Shenmai injection in the processes of storing and high temperature sterilization is obviously delayed, and the stability of the pharmaceutical composition is increased; besides, the safety of thepolyethylene glycol 12-hydroxy stearic acid ester is higher than that of the polysorbate-80 and the dosage thereof is lower, thus the probability and the risk of untoward reactions of the pharmaceuticpolyethylene glycol 12-hydroxy stearic acid ester is higher than that of the polysorbate-80 and the dosage thereof is lower, thus the probability and the risk of untoward reactions of the pharmaceutical com

Description

technical field The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for injection that improves the safety of Shenmai injection and a preparation method thereof Background technique The standards of Shenmai injection are recorded in the drug standards issued by the Ministry of Health (Chinese medicine prescription preparations), and the raw materials are red ginseng and Ophiopogon japonicus, which belong to Chinese medicine injections. It has the effects of replenishing qi and solidifying, nourishing yin and promoting body fluid, and promoting pulse. It is clinically used to treat shock, coronary heart disease, viral myocarditis, chronic pulmonary heart disease, and neutropenia of Qi and Yin deficiency. It can improve the immune function of tumor patients. When used in combination with chemotherapy drugs, it has a certain synergistic effect and can reduce the toxic and side effects caused by chemotherapy drugs....

AI Technical Summary

Problems solved by technology

In addition, the traditional Chinese medicine injection itself still has the problem that the pH value of the solution drops significantly during the sterilization and storage process, and polysorbate 80 (Tween 80) is prone to rancidity, which accelerates the drop of the pH value of the liquid medicine.

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