Principle of quantitative trait locus (QTL) positioning

A seat and group technology, applied in the field of molecular biology, can solve difficult problems such as application

Inactive Publication Date: 2010-06-30
李祥
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Problems solved by technology

However, due to the limitation of the number of markers, experimental means and

Method used

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Embodiment Construction

[0004] 1. Parent selection

[0005] The selection of parents directly affects the scope of application of the established population. Generally, parents should be selected from three aspects: (1) Genetic differences between parents. The genetic difference between the parents used to construct the population should be neither too large nor too small. If the difference is too large, the pairing and recombination between hybrid chromosomes will be inhibited, resulting in a low recombination rate between linked loci, resulting in serious partial segregation, reducing the credibility of the established population, and even leading to The offspring of the cross are sterile, which affects the construction of the population; if the difference is too small, the DNA polymorphism between the parents will be relatively low, which will reduce the number of polymorphic probes that can be used for QTL mapping and affect the positioning accuracy. The genetic difference between the parents i...

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Abstract

The invention relates to a principle of quantitative trait locus (QTL) positioning. The QTL refers to the position of a gene for controlling quantitative traits in a genome; A polygenic system for controlling the quantitative trait is used as integration for research on the basis of classical quantitative genetics of polygene hypothesis by several genetic designs and statistical models; and the genetic characteristics of the quantitative traits are described by genetic parameters, such as hereditary capacity and genetic variance.

Description

technical field [0001] The principle of QTL mapping belongs to the field of molecular biology. Background technique [0002] QTL (quantitative trait locus), that is, quantitative trait loci, refers to the position of genes controlling quantitative traits in the genome. Classical quantitative genetics based on the polygenic hypothesis studies the polygenic system controlling a certain quantitative trait as a whole through some genetic designs and statistical models, and uses some genetic parameters such as heritability and genetic variance to describe the genetic characteristics of quantitative traits . However, these parameters are the sum of all gene effects, and cannot effectively analyze the number, specific location, effect size and mode of action of genes controlling the expression of traits, so it is difficult to achieve genetic manipulation of quantitative traits (Xu Jianlong et al., 2001). The discovery and use of genetic markers has promoted the development of stu...

Claims

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Application Information

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IPC IPC(8): C12Q1/68C12Q1/02
Inventor 李祥
Owner 李祥
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