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Application of cyclosporin A in preparing anti-rotavirus medicaments

A rotavirus, cyclosporine technology, applied in the direction of antiviral agents, cyclic peptide components, etc., can solve the problems such as cyclosporine A that have not yet been seen, and meet the needs of clinical treatment, ensure physical health, and solve problems with poor results. Effect

Inactive Publication Date: 2010-09-29
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no relevant report on the anti-rotavirus aspect of cyclosporine A at home and abroad.

Method used

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  • Application of cyclosporin A in preparing anti-rotavirus medicaments
  • Application of cyclosporin A in preparing anti-rotavirus medicaments
  • Application of cyclosporin A in preparing anti-rotavirus medicaments

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Embodiment Construction

[0016] Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. The experimental method that does not indicate specific conditions in the preferred embodiment is usually according to conventional conditions, such as described in the Molecular Cloning Experiment Guide (Third Edition, J. Sambrook et al., translated by Huang Peitang, etc., Science Press, 2002) conditions, or as recommended by the manufacturer.

[0017] 1. Proteomics method to analyze the protein change spectrum of host cells infected by rotavirus. Use 13cm pH3-11NL IPG prefabricated gel strips for two-dimensional electrophoresis (IEF) to analyze infection with rotavirus Wa strain or SA11 strain and mock infection (mock infected) MA104 cell protein profile expression ( figure 1 A, B). Taking the simulated infection group as the control, 772 and 798 protein spots could be detected in the Wa strain infection group, and 1230 and 1312 protei...

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Abstract

The invention discloses the application of cyclosporin A in preparing of anti-rotavirus medicaments. by combining with human cyclophilin A, the cyclosporin A can block interaction of rotavirus VP6 protein and the human cyclophilin A, thereby inhibiting the formation of rotavirus particles to achieve the effect of resisting rotavirus. Adopting the cyclosporin A as an active ingredient, it is helpful to develop specific anti-rotavirus medicaments with high efficiency and low toxin.

Description

technical field [0001] The present invention relates to a new application of the compound, in particular to a new application of cyclosporine A. Background technique [0002] Rotavirus (RV) infection is the main cause of diarrhea in infants and young children, causing about 125 million cases of gastroenteritis in children every year, resulting in 352,000-592,000 deaths of children under the age of 5 due to rotavirus infection, mainly in developing countries. nation. [0003] Rotavirus belongs to the family Reoviridae and is a double-stranded RNA (dsRNA) virus without a cell membrane. Each of the 11 dsRNAs wraps 1 molecule of RNA-dependent RNA polymerase (VP1) and 1 molecule of guanylate and methyltransferase ( VP3) is located at the core of the virus particle and encodes 12 proteins, including 6 structural proteins (VP1-4, 6-7) and 6 non-structural proteins (NSP1-6). VP2 constitutes the inner capsid of rotavirus to enclose the viral genome; the middle capsid composed of VP...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/13A61P31/14
Inventor 李晋涛何海洋吴玉章
Owner ARMY MEDICAL UNIV
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