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Medicinal absorbable and degradable biological anti-adhering material

An anti-adhesion and biological technology, applied in the field of medical materials, can solve the problems of rapid material degradation and absorption, poor flexibility and traction index, mismatching use requirements, etc., and achieve simple operation process, good compatibility, safety and highly effective effect

Active Publication Date: 2011-07-06
北京百利康生化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are still a series of problems that need to be solved urgently in the preparation of medical degradable biomaterials commonly used at home and abroad, such as: (1) the material is brittle and uneven, and the flexibility and tensile index are poor, which affects the use effect; (2) the mechanical properties are uncontrollable , it is difficult to shape under the condition of water in the body; (3) The degradation and absorption of the material in the body is too fast, which does not match its use requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Choose 65 kg of chitosan solution, 20 kg of polylactic acid; at 220°C, cross-linking reaction for 1.5 hours, freeze-dried and then aseptically packaged, which is the finished product.

[0025] The degradation time of the finished product of the present embodiment 1 is 7 days.

Embodiment 2

[0027] Select 60 kg of chitosan solution, 10 kg of polylactic acid, and 3 kg of polyethylene glycol; react at 180°C for 4.5 hours, freeze-dry and then aseptically package to obtain the finished product.

[0028] The degradation time of the finished product of present embodiment 2 is 15 days.

Embodiment 3

[0030] Select 55 kg of chitosan solution, 8 kg of polylactic acid, 4 kg of polyethylene glycol, and 5 kg of hyaluronic acid, react at 160° C. for 3 hours, freeze-dry, and aseptically package to obtain the finished product.

[0031] The degradation time of the finished product of present embodiment 3 is 20 days.

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PUM

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Abstract

The invention discloses a medicinal absorbable and degradable biological anti-adhering material. The main component of the biological anti-adhering material is chitosan and the chitosan is a pure natural extract, so the biological anti-adhering material has low cost and rich source and does not produce any toxic or side effect during use. The anti-adhering material is a copolymer of the followingraw materials in part by weight: 10 to 75 percent of chitosan, 0 to 60 parts of hyaluronic acid, 0 to 30 parts of polyethylene glycol and 1 to 45 parts of polylactic acid. The biological anti-adhering material placed in vivo for 7 to 30 days can be fully degraded and absorbed and does not coagulate into bulk foreign matters. Because of high safety and effectiveness compared with the traditional material, most patients are willing to accept the medicinal anti-adhering material of the invention; and the operating process is simpler, and the medicinal personnel of each level can operate and accurately use the medicinal anti-adhering material after training.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular, the invention is a bioabsorbable and degradable anti-adhesion material for medical use. Background technique [0002] At present, in surgical operations, anti-adhesion materials are often used to prevent postoperative adhesions. At present, there are still a series of problems that need to be solved urgently in the preparation of medical degradable biomaterials commonly used at home and abroad, such as: (1) the material is brittle and uneven, and the flexibility and pulling index are poor, which affects the use effect; (2) the mechanical properties are uncontrollable , It is difficult to shape under the condition of water in the body; (3) The degradation and absorption of the material in the body is too fast, which does not match its use requirements. Therefore, it is necessary to improve these medical degradable biomaterials to overcome the above-mentioned problems. C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/14A61L27/26A61L27/58
Inventor 王国强施波
Owner 北京百利康生化有限公司
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