Tectorigenin derivatives, and preparation method and application thereof in treating prostatic diseases

Abstract

The invention relates to the field of natural medicinal chemistry, in particular to tectorigenin derivatives (I). R is defined as the specification. The derivatives and pharmaceutically acceptable salts thereof have good water solubility and can be used for improving or treating the diseases such as prostatic hypertrophy and / or chronic prostatitis and the like.

Description

technical field The present invention relates to the field of natural medicinal chemistry, in particular to a class of irisin derivatives, specifically irisin derivatives with the chemical name of 5,7,4'-trihydroxy-6-methoxy isoflavones, the The derivatives and pharmaceutically acceptable salts of the derivatives are pharmaceutical compositions with active ingredients and corresponding preparation methods thereof, and their application in improving or treating hyperplasia of the prostate and / or chronic prostatitis. Background technique Benign prostatic hyperplasia (BPH) and prostatitis are two of the most common diseases of the male genitourinary tract. Frequent urination, urgency, waiting for urination, urinary retention, etc. often occur, which are difficult to cure. The age of onset of the disease is mostly after the age of 50, and the incidence rate continues to increase with age, especially the incidence rate of benign prostatic hyperplasia (BPH) is significantly incre...

AI Technical Summary

Problems solved by technology

However, the water solubility of irisin is very poor, which limits its clinical application.

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