Monoclonal antibody of anti-gonadotropin-releasing hormone receptor and application thereof

Abstract

The present invention provides a mouse hybrid tumor cell strain (preserving number: ATCC GHR-106PTA-10252) and a monoclonal antibody (GHR-106) of anti-gonadotropin-releasing hormone receptor which is secreted from the mouse hybrid tumor cell strain. The antibody can perform effective inbibitional effect for the tumor cell through combining with the surface receptor of tumor cell. Then the antibody can be used for the diagnosis and treatment process of tumor and the application for preparing the antitumor drug.

Description

technical field The invention relates to the field of biotechnology, in particular to an anti-gonadotropin-releasing hormone receptor monoclonal antibody fragment and its monoclonal antibody and application. Background technique Gonadotropin-releasing hormone (GnRH) was originally defined as a decapeptide hormone. Its function is to stimulate the release of gonadotropins. Gonadotropins such as LH and FSH are released by specifically binding to the anterior pituitary cells that have GnRH receptors outside the specific cell membrane. Subsequent studies have shown that GnRH and its receptors also play roles in many normal and malignant cells or tissues outside the pituitary gland, but the role of cells or tissues outside the pituitary gland has not yet been fully understood. However, the antiproliferative efficacy of GnRH or its analogues on cancer cells in different human tissues and organs has been reported. Clinical studies of many GnRH analogues linked to cytotoxic drugs...

AI Technical Summary

Problems solved by technology

Subsequent studies have shown that GnRH and its receptors also play roles in many normal and malignant cells or tissues outside the pituitary gland, but the role of cells or tissues outside the pituitary gland has not been fully understood

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