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Chinese medicinal compound suppository for treating endometritis of livestock and preparation method thereof

A technology for endometritis and compound suppositories, which is applied in the directions of suppository delivery, pharmaceutical formulations, and non-active ingredients medical preparations, etc., can solve the problems of large quality and volume of suppositories, weak targeting, etc. The effect of preservation and stable drug quality

Inactive Publication Date: 2011-08-17
NINGXIA UNIVERSITY
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  • Application Information

AI Technical Summary

Problems solved by technology

The quality and volume of the suppository prepared by this method are large, and the targeting of administration is not strong

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Extraction of active ingredients of traditional Chinese medicine

[0024] (1) Extraction of active ingredients of Coptis chinensis: crush Coptis chinensis through a 50-mesh sieve, take 2 grams of crushed Coptis chinensis powder, add about 20 ml of ethanol with a volume concentration of 80%, put it into an ultrasonic extractor, and extract at 50°C for 30 minutes , filtered through gauze, and collected the filtrate; 16 ml of alcohol with a volume concentration of 80% was added to the medicinal residues, ultrasonically extracted for 40 minutes again, and the filtrates collected twice were combined, and the filtrate was concentrated into about 2 ml of liquid extract with a rotary evaporator.

[0025] (2) Extraction of effective components in Cortex Phellodendri: Weigh 1 gram of Cortex Phellodendri cut into thin slices and put it into a round bottom flask, then add about 8 ml of ethanol with a volume concentration of 55% to the flask, and put it in a water bath at about 80...

Embodiment 2

[0039] On the basis that the active ingredients of Chinese medicines in Example 1 are extracted substantially unchanged, the suppository formula is changed as follows:

[0040] Mix 10g of polyethylene glycol 600, 8g of polyethylene glycol 6000, and 1g of Tween 80, put them in a 65°C water bath, heat and melt, stir well, slowly add 12g of medicine and stir well, pour into 5g of suppository mold, put in 4°C Refrigerate for 30 minutes to remove from the mold and rest. A traditional Chinese medicine suppository is prepared. The prepared suppository has a smooth surface, uniform drug distribution, brownish color, aromatic smell and certain hardness.

[0041] 4. Observation of clinical effect.

[0042] Select 20 dairy cows with acute endometritis before uterine atresia occurred within 15 days postpartum, inject two suppositories of this traditional Chinese medicine into the uterus, once every other day, and the cure rate reaches 90% after three times in a row. 20 cows with invisi...

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Abstract

The invention relates to a traditional Chinese medicine, in particular to a Chinese medicinal compound suppository for treating endometritis of livestock and a preparation method thereof. The Chinese medicinal compound suppository is prepared by mixing 1 to 2 parts of golden thread, 1 part of cortex phellodendri, 1 part of lightyellow sophora root, 1 to 2 parts of leonurus heterophyllus, 1 to 2 parts of safflower, 1 to 2 parts of Chinese angelica, 1 part of astragalus and a suppository matrix. The method for preparing the Chinese medicinal compound suppository for treating the endometritis ofthe livestock comprises the following steps of: extraction of active ingredients of each traditional Chinese medicine, concentrating, drying, pulverizing and preparation of the suppository. The suppository has the advantages of pure Chinese medicinal preparation, no problem of antibiotic residues, stable medicinal quality and easy carrying and storage. For the acute endometritis and hidden endometritis of dairy cattle, the two Chinese medicinal suppositories are put into uteruses once every other day, and after the Chinese medicinal suppositories are used continuously for three times, the curative rate reaches 83 percent; and for the hidden endometritis of the dairy cattle during oestrum, the two suppositories are dissolved in 50 milliliters of physiological saline to perform the treatment of intrauterine administration, the suppositories are used once every other day and are used continuously for three times, and the curative rate reaches 62.5 percent.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine compound suppository for treating livestock endometritis and a preparation method thereof. Background technique [0002] Endometritis is a common reproductive system disease in dairy cows, and it is a mucoid or purulent inflammation of the endometrium that commonly occurs after parturition. Due to the inflammatory process of uterine mucosa, inflammatory products and bacterial toxins, the sexual cycle of livestock is disordered, and the vitality of sperm and embryo implantation are directly endangered, resulting in infertility in mating, which is one of the main causes of infertility in livestock. . The incidence of endometritis in dairy cows is very high. According to foreign statistics, the average incidence of endometritis in adult dairy cows is 30%-40%, while the incidence in my country is about 20%-50%. Endometritis makes the calving interval P...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61K9/02A61K47/34A61P15/00A61K47/10A61K47/26
Inventor 何生虎李新民
Owner NINGXIA UNIVERSITY
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