34results about How to "Improve drug quality" patented technology

The invention relates to medicinal composition solution. The medicinal composition solution comprises 2-methy-5-imido-benzo-[d][1,3] oxazine [5-b] pyrazole, arginine, an antioxidant and a solvent, wherein the weight ratio of the 2-methy-5-imido-benzo-[d][1,3] oxazine [5-b] pyrazole, the arginine, the antioxidant to the solvent is 1:0.5 to 15:0.1 to 1.5:10 to 400; and the solvent is pharmaceuticalwater. The medicinal composition has high water dissolubility, and is difficult to degrade under the protection of the antioxidant. The medicinal composition solution has stable injection exposure, has stable effect of inhibiting coloring change, is not hemolytic, does not separate crystal in serum out and is safe to use.

The invention provides a traditional Chinese medicine composition, in particular to a medicinal syrup for treating wind-heat common cold in children, wherein each ml of syrup comprises 0.0024-0.02 mg of β-pinene, 0.0050-0.2 mg of menthol, 0.068-3 mg of continuous Aromain and 0.64-5mg of gardeniside, the syrup raw materials include forsythia, light tempeh, mint, nepeta, gardenia, rhubarb, artemisia, red peony, betel nut, magnolia, skullcap, pinellia, bupleurum , Licorice. The syrup has clear active ingredients and stable quality. In the preparation process, some traditional Chinese medicines are steamed and assisted by microwave extraction, which improves the efficiency and curative effect.

The invention relates to a capsule real-time inspection method with double detection, which comprises the following steps: 1) providing a capsule real-time test platform with double detection, which includes a near-infrared detection mechanism, a visible light detection mechanism and a main controller, wherein the near-infrared detection mechanism and the visible light detection mechanism respectively perform defect detection to every capsule and the main controller is respectively connected to the near-infrared detection mechanism and the visible light detection mechanism for determining a capsule rejection strategy according to a defect detection result from the near-infrared detection mechanism and the visible light detection mechanism; and 2) performing inspection with the test platform. According to the method, there are two detection methods are available to detect the capsules, thereby improving reliability of capsule test.

The invention discloses a kind of cinnamon twig and tuckahoe pellets, which are coated pellets, including a core and a film coating wrapped around the core, wherein: the core is composed of cinnamon twigs, poria cocos, cortex moutan, and red peony The five raw materials of peach kernel and peach kernel are made with a weight ratio of 1:1:1:1:1, and the diameter of the pellet core is 1.5mm to 2.0mm; the coating material used for the film coating is an alcohol-soluble gastric-soluble film coating pre- Mixture; the weight of the film coating layer is 1.8-2.2% of the weight of the ball core. The Guizhi Fuling pellet has the effects of promoting blood circulation and removing blood stasis, eliminating phlegm and relieving pain, and regulating qi and blood; and the drug quality is stable, the distribution area of ​​the drug on the surface of the gastrointestinal tract is increased, the irritation is small, the bioavailability is high, and the curative effect is good. The invention also discloses a preparation method of the cinnamon twig and poria pellets. The pellets are prepared by a specific process and then coated. The sterilization effect is good, the molding process is stable, and the quality of the prepared medicine is reliable.

The invention relates to a traditional Chinese medicine, in particular to a Chinese medicinal compound suppository for treating endometritis of livestock and a preparation method thereof. The Chinese medicinal compound suppository is prepared by mixing 1 to 2 parts of golden thread, 1 part of cortex phellodendri, 1 part of lightyellow sophora root, 1 to 2 parts of leonurus heterophyllus, 1 to 2 parts of safflower, 1 to 2 parts of Chinese angelica, 1 part of astragalus and a suppository matrix. The method for preparing the Chinese medicinal compound suppository for treating the endometritis ofthe livestock comprises the following steps of: extraction of active ingredients of each traditional Chinese medicine, concentrating, drying, pulverizing and preparation of the suppository. The suppository has the advantages of pure Chinese medicinal preparation, no problem of antibiotic residues, stable medicinal quality and easy carrying and storage. For the acute endometritis and hidden endometritis of dairy cattle, the two Chinese medicinal suppositories are put into uteruses once every other day, and after the Chinese medicinal suppositories are used continuously for three times, the curative rate reaches 83 percent; and for the hidden endometritis of the dairy cattle during oestrum, the two suppositories are dissolved in 50 milliliters of physiological saline to perform the treatment of intrauterine administration, the suppositories are used once every other day and are used continuously for three times, and the curative rate reaches 62.5 percent.

The invention relates to a traditional Chinese medicine composition for treating leukopenia caused by cancer chemotherapy and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations. The adopted technical scheme is prepared from the following raw materials: 15-90 parts of Astragalus membranaceus, 10-70 parts of ox horn gills, 15-60 parts of Gallatia chinensis, 15-60 parts of Agrimony, and 10-50 parts of turpentine share. In the prescription, Astragalus is the king, ox horn and gills are the ministers, galanthus and Agrimony are the ministers, and the pine knot is the minister, which is in line with the theory of traditional Chinese medicine for treating consumptive labor. Another object of the present invention is to provide a preparation method of the traditional Chinese medicine composition of the present invention. The traditional Chinese medicine composition of the present invention can also be added with pharmaceutically acceptable carriers, which include but are not limited to excipients, flavoring agents, fillers, binders, wetting agents, disintegrating agents and lubricants. Clinical examples show that the traditional Chinese medicine preparation of the present invention is a reliable, safe and effective medicine for treating leukopenia caused by cancer chemotherapy, and is worthy of further promotion.

The invention relates to the technical field of medicine purification, and discloses a highly-pure tacrolimus compound and a preparation method thereof. The method comprises the following steps: preprocessed crude tacrolimus undergoes silver-containing polymer resin column chromatography elution, the above obtained eluate is concentrated, and the above obtained concentrate is re-crystallized to obtain highly-pure tacrolimus. The method has the advantages of simplicity in large-scale production operation, small use amount of a solvent, short production period, low cost and environmental protection; and an HPLC detection result shows that ascomycin and dihydrotacrolimus which are most difficult to separate in the crude tacrolimus are completely removed. The normalization purity of tacrolimus is 99% or above, and obtained tacrolimus crystals have the characteristics of uniform particle size distribution, small internal stress and bulk density, and good stability, fluidity, dispersibility and dissolvability. The quality and the medication safety of tacrolimus are improved.

The invention relates to a real-time capsule checkout platform through double detection. The real-time capsule checkout platform through double detection comprises a near-infrared detecting mechanism, a visible light detecting mechanism and a master controller, wherein the near-infrared detecting mechanism and the visible light detecting mechanism performs defect detection on each capsule, the master controller is connected with the near-infrared detecting mechanism and the visible light detecting mechanism, and a capsule rejecting strategy is determined on the basis of defect detection results of the near-infrared detecting mechanism and the visible light detecting mechanism. By means of the real-time capsule checkout platform through double detection, to-be-checked capsules can be detected through two detecting modes, and the reliability of capsule detection is improved.