Compound preparations for treating hypertension and method for preparing the same

A technology for compound preparations and high blood pressure, which is applied to medical preparations containing active ingredients, pill delivery, and pharmaceutical formulations, etc. It can solve problems such as poor stability of tablet preparations, excessively strong antihypertensive synergistic effects, and impact on drug stability. , to achieve a reliable and safe step-down effect, reduce stability decline, and avoid the effect of stability decline

Inactive Publication Date: 2008-03-05
湖北丝宝药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Telmisartan and diuretics are granulated separately, and the antihypertensive preparations obtained after the granules are mixed and pressed into tablets. When the two antihypertensive active ingredients are disintegrated and released at the same time, the synergistic antihypertensive effect may lead to the occurrence of hypotensive adverse reactions; In addition, the above two components may cause poo

Method used

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  • Compound preparations for treating hypertension and method for preparing the same
  • Compound preparations for treating hypertension and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0072] Example one

[0073] The raw and auxiliary materials used to prepare the 1000-piece compound preparation of Example 1 of the present invention are shown in Table 6 below.

[0074] Table 6 Consumption of raw and auxiliary materials of 1000 tablets of compound preparation in Example 1 of the present invention

[0075] Internal chip components

[0076] Preparation:

[0077] 1. Internal chip preparation

[0078] Hydrochlorothiazide, lactose, microcrystalline cellulose, sodium carboxymethyl starch and starch were passed through a 100-mesh sieve, respectively, and set aside. Weigh 4g of starch, and make 10% starch slurry by the pulping method, and set aside. Weigh 12.5 g of hydrochlorothiazide, 30 g of lactose, 30 g of microcrystalline cellulose, and 4 g of sodium carboxymethyl starch, and add them to the wet granulator, and add 10% starch slurry to the soft material while stirring. The soft material is granulated through a 20-mesh woven sieve, and air-dried at 70°C for...

Example Embodiment

[0084] Example two

[0085] The raw and auxiliary materials used to prepare the 1000-piece compound preparation of Example 2 of the present invention are shown in Table 7 below.

[0086] Table 7 Consumption of raw and auxiliary materials of 1000 tablets of compound preparation in Example 2 of the present invention

[0087] Inner sheet components

[0088] Preparation:

[0089] 1. Internal chip preparation

[0090] Hydrochlorothiazide, lactose, microcrystalline cellulose, sodium carboxymethyl starch and starch were passed through a 100 mesh sieve for use. Weigh 4g of starch, and prepare 10% starch slurry by the pulping method for use. Weigh 12.5 g of hydrochlorothiazide, 30 g of lactose, 30 g of microcrystalline cellulose, and 4 g of sodium carboxymethyl starch, and mix them uniformly in equal amounts, add them to a wet granulator, and add 10% starch slurry to the soft material while stirring and chopping. The soft material is granulated through a 20-mesh woven sieve, and ...

Example Embodiment

[0095] Example three

[0096] Preparation:

[0097] 1. After the inner core is prepared according to the steps of Example 1, the inner core coated tablet is prepared according to the following method.

[0098] Coating slurry preparation: Dissolve 16 g of Opadry (purchased from Shanghai Colorcon Coating Technology Co., Ltd.) in an appropriate amount of 70%-75% ethanol solution. After fully swelling for 45 minutes, stir to make the dissolution evenly. .

[0099] Coating operation: put the pressed inner chip into the coating machine, start the hot air device and exhaust device, adjust the speed to 2-3r / min for preheating. When the temperature rises to 50-60℃, turn on the peristaltic pump, adjust the speed to 6-12r / min, control the air inlet temperature at 90-100℃, and spray the spraying speed at 130-150g / min, and spray coating. The flow rate and time during spraying are well controlled to prepare the inner core coated tablet.

[0100] 2. The preparation of the core outer layer partic...

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Abstract

The present invention discloses one kind of hypertension treating compound preparation and its preparation process. The compound preparation includes one tablet core containing diuretic in effective treating amount and pharmaceutically acceptable carrier, and one coating containing telmisartan in effective treating amount and pharmaceutically acceptable carrier. The content of diuretic is 1.5-10 wt% of the tablet core, and that of telmisartan is 3.5-25 wt% of the coating. The compound preparation is prepared through preparing the tablet core pellet and the coating pellet separately with medicine material and supplementary material and the subsequent pressing the coated tablet in a rotary coating machine. The hypertension treating compound preparation has reliable and safe blood pressure reducing effect and high stability.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for treating hypertension and a preparation method thereof, in particular to a compound preparation containing telmisartan and a diuretic and a preparation method thereof. Background technique [0002] Hypertension is a major risk factor for heart, brain, and renal vascular diseases. In most countries, as high as 15%-25% of adults suffer from hypertension. Hypertension is the leading cause of death and disability in adults. [0003] In the past 40 years, researchers have researched and developed several new drugs to treat hypertension; diuretics in the 1960s, beta blockers in the 1970s, and calcium channel antagonists ( calcium channel blockers) and angiotensin converting enzyme inhibitors (Angiotens in-Converting-Enzyme Inhibitors, referred to as ACEI). After years of clinical application, the therapeutic efficacy of these drugs has been affirmed by clinicians and patients. However, in the course...

Claims

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Application Information

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IPC IPC(8): A61K31/4184A61K31/4965A61K31/549A61K45/06A61K9/20A61P9/12A61K31/341A61K31/40A61K31/4035
Inventor 许发祥黄自强阮建华李德全朱强龚明峰洪鸣石新明姚莹萍
Owner 湖北丝宝药业有限公司
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