Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Preparation technology of captopril tablets

A captopril tablet and a preparation process technology, applied in the field of captopril preparations, can solve the problems of high production cost, complicated operation and the like, and achieve the effects of improving bioavailability, simplifying the process route and saving costs

Inactive Publication Date: 2020-06-19
仁和堂药业有限公司
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the current production process of captopril tablets is wet granulation and tabletting, which is cumbersome in operation, high in production cost, and complicated.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The prescription for captopril tablets 1000 tablets is:

[0028] Captopril 25g, silicified microcrystalline cellulose 300g, crospovidone 4g, hydroxypropyl cellulose 4g, talcum powder 1g;

[0029] 1) The preparation method is: weigh the raw and auxiliary materials of the prescription amount;

[0030] 2) Screening: pass all the raw and auxiliary materials weighed through 80-mesh sieve, and set aside;

[0031] 3) Mixing: add the sieved captopril, silicified microcrystalline cellulose, crospovidone, and hypromellose into the mixer and mix thoroughly;

[0032] 4) Total blending: In step 3), add sieved hypromellose and mix thoroughly to obtain mixed powder;

[0033] 5) Tablet compression: use the mixed powder in step 4), according to the mass of each tablet is 0.230g.

Embodiment 2

[0035] The prescription for captopril tablets 1000 tablets is:

[0036] Captopril 25mg, PH102 microcrystalline cellulose 200g, croscarmellose sodium 4g, povidone 0.6g, magnesium stearate 0.8g;

[0037] 1) The preparation method is: weigh the raw and auxiliary materials of the prescription amount;

[0038] 2) Screening: pass all the raw and auxiliary materials weighed through 80-mesh sieve, and set aside;

[0039] 3) Mixing: add the sieved captopril, PH102 microcrystalline cellulose, croscarmellose sodium and povidone into the mixer and mix thoroughly;

[0040] 4) Total blending: in step 3), add the sieved magnesium stearate and mix thoroughly to obtain a mixed powder;

[0041] 5) Tablet compression: use the mixed powder in step 4), according to the mass of each tablet is 0.230g

Embodiment 3

[0043] The prescription for captopril tablets 1000 tablets is:

[0044] Captopril 25mg, PH200 microcrystalline cellulose 200g, croscarmellose sodium 4g, povidone 0.6g, silicon dioxide 0.8g;

[0045] 1) The preparation method is: weigh the raw and auxiliary materials of the prescription amount;

[0046] 2) Screening: pass all the raw and auxiliary materials weighed through 80-mesh sieve, and set aside;

[0047] 3) Mixing: add the sieved captopril, PH200 microcrystalline cellulose, croscarmellose sodium and povidone into the mixer and mix thoroughly;

[0048] 4) Total blending: in step 3), add sieved silicon dioxide, and fully mix to obtain a mixed powder;

[0049] 5) Tablet compression: use the mixed powder in step 4), according to the mass of each tablet is 0.230g.

[0050] The beneficial effects of the present invention are:

[0051] 1. The content of impurity captopril disulfide in the preparation is significantly reduced, the quality of the drug is improved, and the sta...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses a preparation technology of captopril tablets. The tablets are prepared from the following components in weight percentages: captopril, a filler, a disintegrant, a lubricant and an adhesive. Weighing, screening and mixing are conducted, compressable auxiliary materials are used and direct tableting is conducted to prepare the captopril tablets. The preparation technology reduces the content of hydrolyzed impurity captopril disulfide in the captopril, improves the dissolution rate, and is simple, cost-saving, good in stability, etc.

Description

technical field [0001] The invention belongs to the field of captopril preparations, in particular to a preparation process of captopril tablets. Background technique [0002] As we all know, cardiovascular disease has become the biggest enemy that threatens human life and health, and hypertension is the chief culprit in cardiovascular disease. The advent of captopril, the first angiotensin-converting enzyme (ACE) inhibitor, is undoubtedly a milestone event in the history of human combat against hypertension. Captopril is a best-selling drug that has been approved for use in nearly 80 countries around the world. It is also the first ACE-I to come out, and it is currently the most widely used and orally effective ACE-I. It is widely used clinically for hypertension and heart failure, especially for renal hypertension. It is also suitable for the treatment of hypertensive patients with diabetes, hyperlipidemia, bronchial asthma, left ventricular hypertrophy and heart failu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K47/38A61K47/32A61K31/401A61P9/12
CPCA61K9/2054A61K9/2027A61K31/401A61P9/12
Inventor 林凡儒刘永郭增光毛传伟王美成
Owner 仁和堂药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com