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Chinese angelica root and sophora root pellet, and preparation method thereof

A technology of ginseng pellets and angelica, which is applied in the field of angelica flavescens pellets and its preparation, can solve the problems affecting the quality stability of the preparation molding process and the normal performance of the clinical curative effect of the compound traditional Chinese medicine, so as to achieve stable and reliable clinical curative effect, Good hardness and high productivity

Inactive Publication Date: 2011-06-22
四川禾邦阳光制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for different raw materials, the excipients (including the types and dosage ratios) and preparation processes that can be selected when making pellets are also different, as well as suitable coating materials and coating processes. It is still a topic worthy of research; especially the research on pellets of compound Chinese medicine preparations, which will not only affect the stability of the preparation process and drug quality, but also affect the normal clinical efficacy of compound Chinese medicines.
Therefore, there is no one-size-fits-all adjuvant formula and / or preparation process that can be commonly used in the pellet preparations of all drugs

Method used

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  • Chinese angelica root and sophora root pellet, and preparation method thereof
  • Chinese angelica root and sophora root pellet, and preparation method thereof
  • Chinese angelica root and sophora root pellet, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The present embodiment angelica flavescens pellets comprise ball core and the film coat of ball core outer wrapping, wherein:

[0052] The core of the ball is made of the raw materials Angelica sinensis and Sophora flavescens in a weight ratio of 1:1; the coating material used for the film coating is Shanghai Colorcon stomach-soluble film coating premix; the weight of the film coating layer is the weight of the core 3%.

[0053] The present embodiment angelica flavescens pellets are prepared by the following method: take the raw material drug angelica and flavescens of the ratio, pulverize, and pass through a 100 mesh sieve; Amount of water (35ml); first take 30% (60g) of the total amount of the medicinal powder, add the calculated amount of water (35ml) as a binder, mix well, and granulate with 20 meshes; roll the upper coating pan, and sprinkle the rest of the medicinal powder (140g) Powder into pills; take out of the pan, dry, sieve, coat with film, and get ready. ...

Embodiment 2

[0055] The present embodiment angelica flavescens pellets comprise ball core and the film coat of ball core outer wrapping, wherein:

[0056] The core of the ball is made of the raw materials Angelica sinensis and Sophora flavescens in a weight ratio of 1:1; the coating material used for the film coating is Shanghai Colorcon stomach-soluble film coating premix; the weight of the film coating layer is the weight of the core 2%.

[0057] In this embodiment, the Angelica flavescens pellets are prepared by the following method: get the raw materials Angelica and Sophora flavescens in the ratio, pulverize them, and pass through a 100 mesh sieve; add 15 ml of water to 100 g of medicated powder (calculated on the basis of 200 g of the total amount of medicated powder) to calculate the amount of water added (30ml); first take 25% (50g) of the total amount of the medicinal powder, add the calculated amount of water (30ml) as a binder, mix well, and granulate with 20 meshes; roll the up...

Embodiment 3

[0059] The present embodiment angelica flavescens pellets comprise ball core and the film coat of ball core outer wrapping, wherein:

[0060] The core of the ball is made of the raw materials Angelica sinensis and Sophora flavescens in a weight ratio of 1:1; the coating material used for the film coating is Shanghai Colorcon stomach-soluble film coating premix; the weight of the film coating layer is the weight of the core 2.5%.

[0061] In this embodiment, the angelica flavescens pellets are prepared by the following method: get the raw materials angelica and flavescens of the ratio, pulverize them, and pass through a 100-mesh sieve; (40ml); first take 35% (70g) of the total amount of the medicinal powder, add the calculated amount of water (40ml) as a binder, mix well, and granulate at 20 mesh; roll the upper coating pan, and sprinkle the rest of the medicinal powder (130g) Form into pellets; take out of the pan, dry, sieve, and coat with film to obtain.

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Abstract

The invention discloses an angelica and light yellow sophora root micropill, comprising a pill core and a film coat coating the pill core, wherein, the pill core is prepared by bulk drugs, such as angelica and light yellow sophora root of which the proportion by weight is 1 to 1; during the preparation of the pill core, water is used as a binding agent, and 15 ml to 20 ml of water matches 100g ofmedicine powder; and coating materials of the film coat is gastric solubility film coating premix, and the weight of the film coat is 2 to 3 percent of the weight of the pill core. The medicine containing the bulk drugs, such as the angelica and the light yellow sophora root, is processed into micropills by the specific auxiliary material formula and the coating process; and the moulding process and the medical quality are stable, the distribution area of the medicine on the gastrointestinal tract surface is expanded, and the micropill has low stimulation, high bioavailability and stable and reliable clinical efficacy. The invention also discloses a method for preparing the angelica and light yellow sophora root micropill.

Description

technical field [0001] The invention relates to an angelica flavescens pellet and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Angelica sinensis: It is the dry root of Angelica sinensis (Oliv.) Diels, an umbrella plant; the active ingredients are mainly volatile oil, ligustilide, and water-soluble ingredients such as ferulic acid. It was first recorded in "Shen Nong's Materia Medica". Meaning: can nourish blood and activate blood circulation, regulate menstruation and relieve pain, moisten dryness, smooth intestines, and its nature and flavor are sweet, pungent, warm. Return liver, heart, spleen channel. "Shen Nong's Materia Medica" says: "The main cough is against the upper qi... various evil sores and golden sores". "Rihuazi Materia Medica" says: "Treat all wind and all blood, replenish all fatigue, break evil blood, nourish new blood and main symptom addiction" and so on. Angelica is sweet...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/489A61K9/16A61P17/00
Inventor 刘文旭肖华张悦宋波伍江蓉
Owner 四川禾邦阳光制药股份有限公司
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