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Pellet of celery seed extract and preparation method thereof

A technology of celery seed extract and celery seed, applied in the field of medicine, can solve problems such as low yield of pellets

Active Publication Date: 2012-11-28
BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of celery seed ethanol extract pellet that can be used for the treatment of gout, and its preparation method, to overcome the problem that the yield of pellet is lower in coating process

Method used

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  • Pellet of celery seed extract and preparation method thereof
  • Pellet of celery seed extract and preparation method thereof
  • Pellet of celery seed extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1, the preparation of pellet

[0063] Prescription ratio:

[0064]

[0065]

[0066] Prepare as follows:

[0067] (1) Take the ethanol extract of celery seed according to the prescription ratio, add auxiliary materials such as microcrystalline cellulose and crospovidone, pulverize and mix;

[0068] (2) adding povidone aqueous solution as binder;

[0069] (3) The pellets were prepared by extrusion-spheronization. The mixed material is extruded into strips at the extrusion speed of 10-40r / min, and the amount of adhesive added is controlled to control the length of the extruded strips; The extrudate is cut off at a rotating speed, and then spheronized at a rotating speed of 30-50Hz for 10-20 minutes to obtain pellets. Move it into a drying room for drying. The drying condition is 30±2°C and the drying time is 12 hours. After drying, it is packaged.

Embodiment 2

[0070] Embodiment 2, the preparation of pellet

[0071] Prescription ratio:

[0072]

[0073] Prepare as follows:

[0074] (1) Take the celery seed ethanol extract according to the prescription ratio, add starch, lactose, carboxymethyl starch sodium and other auxiliary materials, pulverize and mix;

[0075] (2) adding the ethanol solution of ethyl cellulose as binder;

[0076](3) The pellets were prepared by extrusion-spheronization. The mixed material is extruded into strips at the extrusion speed of 10-40r / min, and the amount of adhesive added is controlled to control the length of the extruded strips; The extrudate is cut off at a rotating speed, and then spheronized at a rotating speed of 30-50Hz for 10-20 minutes to obtain pellets. Move it into a drying room for drying, the drying condition is 30±2°C, the drying time is 12 hours, and it is packaged after drying.

Embodiment 3

[0077] Embodiment 3, the preparation of pellet

[0078] Prescription ratio:

[0079]

[0080] Prepare as follows:

[0081] (1) Take the ethanol extract of celery seed according to the prescription ratio, add microcrystalline cellulose, dextrin, croscarmellose sodium and other auxiliary materials, pulverize and mix;

[0082] (2) adding an aqueous solution of hypromellose as a binding agent;

[0083] (3) The pellets were prepared by extrusion-spheronization. The mixed material is extruded into strips at the extrusion speed of 10-40r / min, and the amount of adhesive added is controlled to control the length of the extruded strips; The extrudate is cut off at a rotating speed, and then spheronized at a rotating speed of 30-50Hz for 10-20 minutes to obtain pellets. Move it into a drying room for drying, the drying condition is 30±2°C, the drying time is 12 hours, and it is packaged after drying.

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Abstract

The invention relates to a pellet of a celery seed extract and a preparation method thereof. The pellet comprises the following components in parts by weight: 30 to 90 parts of celery seed extract, 10 to 75 parts of diluent, 0.5 to 10 parts of disintegrating agent, and an optional adhesive. The invention also relates to a coated pellet containing the pellet and a method for preparing the coated pellet. The pellet provided by the invention can be prepared into a slow / controlled release or enteric pellet preparation through combining the slow release or enteric pellet technology. The pellet preparation provided by the invention has the advantages of reasonable types and dosage ratios of adopted main drugs and auxiliary materials, good yield, stability, safety, high dissolution rate, high bioavailability, small side effect and the like and is convenient in drug administration.

Description

Technical field: [0001] The invention belongs to the field of medicine, and relates to a micropill of celery seed extract and a preparation method thereof, in particular to a micropill made of ethanol extract of celery seed which can be used for treating gout and a preparation method thereof. Background technique: [0002] Celery seed is the seed of Apium graveolens L., an umbelliferous plant celery. Celery, also known as parsley and dry celery, is recorded in "Luxianyan Materia Medica". It is an annual or biennial herb of Umbelliferae, and it is cultivated all over the country and around the world. Celery seed is often used in condiments and foods. Celery seed tea has a significant effect on promoting sleep. Its extract has a contraction effect on pregnant and non-pregnant uteri and can be used to treat dysmenorrhea. Traditional Chinese medicine believes that celery seed has the effects of dispersing qi, reducing swelling, diuresis, opening and blocking, and lowering blood...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/23A61K47/38A61K47/36A61K47/32A61P19/06A61K131/00
Inventor 李莉娥蔡正军伊进朝陈海生高永良
Owner BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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