Method for preparing six-ingredient rehmannia-root solid dispersion preparation

A technology of Liuwei Dihuang and Rehmannia glutinosa, which is applied in the field of preparation of Liuwei Dihuang dripping pills, can solve the problems of reduced safety and achieve the effects of high roundness, uniform particles and high drug loading

Inactive Publication Date: 2020-08-14
JIANGSU EHAI PHARMA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the safety study also shows that the safety of the drug is not reduced by ultrafine pulverization.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1. Take Rehmannia glutinosa 1408g, Cortex Moutan 528g, Chinese yam 704g, Cornus officinalis 704g, Alisma 528g and Poria cocos 528g;

[0016] 2. Take 110g of Poria cocos and crush it into fine powder, sieve the remaining part and decoct the remaining Poria cocos with water for three times, 30 minutes each time, filter, combine the filtrate, concentrate to a thick paste; add ethanol to reflux extraction twice, each time for 1 hour , filter, the dregs are set aside, the filtrate recovers ethanol, concentrates to a thick paste; Moutan cortex is steam distilled, and 1mol / L hydrochloric acid solution is added to the collected distillate to crystallize, filter, wash the crystal with water, and dry at low temperature. Grind into a fine powder; distilled aqueous solution, Moutan Cortex dregs, Cornus officinalis dregs, rehmannia glutinosa, Chinese yam, and Alisma alisma, add water and decoct three times, each time for 1 hour, filter, combine the filtrate, pass through the macropor...

Embodiment 2

[0021] 1. Take Rehmannia glutinosa 1408g, Cortex Moutan 528g, Chinese yam 704g, Cornus officinalis 704g, Alisma 528g and Poria cocos 528g;

[0022] 2. Take 110g of Poria cocos and crush it into fine powder, sieve the remaining part and decoct the remaining Poria cocos with water for three times, 30 minutes each time, filter, combine the filtrate, concentrate to a thick paste; add ethanol to reflux extraction twice, each time for 1 hour , filter, the dregs are set aside, the filtrate recovers ethanol, concentrates to a thick paste; Moutan cortex is steam distilled, and 1mol / L hydrochloric acid solution is added to the collected distillate to crystallize, filter, wash the crystal with water, and dry at low temperature. Grind into a fine powder; distilled aqueous solution, Moutan Cortex dregs, Cornus officinalis dregs, rehmannia glutinosa, Chinese yam, and Alisma alisma, add water and decoct three times, each time for 1 hour, filter, combine the filtrate, pass through the macropor...

Embodiment 3

[0027] 1. Take Rehmannia glutinosa 1408g, Cortex Moutan 528g, Chinese yam 704g, Cornus officinalis 704g, Alisma 528g and Poria cocos 528g;

[0028] 2. Take 110g of Poria cocos and crush it into fine powder, sieve the remaining part and decoct the remaining Poria cocos with water for three times, 30 minutes each time, filter, combine the filtrate, concentrate to a thick paste; add ethanol to reflux extraction twice, each time for 1 hour , filter, the dregs are set aside, the filtrate recovers ethanol, concentrates to a thick paste; Moutan cortex is steam distilled, and 1mol / L hydrochloric acid solution is added to the collected distillate to crystallize, filter, wash the crystal with water, and dry at low temperature. Grind into a fine powder; distilled aqueous solution, Moutan Cortex dregs, Cornus officinalis dregs, rehmannia glutinosa, Chinese yam, and Alisma alisma, add water and decoct three times, each time for 1 hour, filter, combine the filtrate, pass through the macropor...

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Abstract

The invention belongs to the field of traditional Chinese medicines and particularly relates to a method for preparing six-ingredient rehmannia-root drop pills. The method comprises the steps of extracting effective medicinal ingredients by employing technologies of aqueous extraction, alcohol precipitation, alcohol extraction and the like, subjecting extracts to concentrating and depressurized drying, and carrying out ultramicro crushing. Through dropping preparation by a modern solid dispersion preparation technology, the yield of extract powder is remarkably increased, the taste is improved, the loss of effective ingredients is lowered, the product quality is improved, and the drug effect is improved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a preparation method of Liuwei Dihuang dripping pills. Background technique [0002] Liuwei Dihuang Dropping Pills are composed of rehmannia glutinosa, dogwood, yam, Alisma, poria cocos, and Moutan cortex. It originated from the "Children's Medicine Syndrome Zhi Jue" written by Qian Yi, a physician in the Song Dynasty. It is a basic prescription for nourishing kidney yin. The prescription has the characteristics of "three tonics and three diarrhea". Liuwei Dihuang Dripping Pills is a representative prescription for nourishing yin and nourishing kidney in traditional Chinese medicine. After hundreds of years of use by doctors, its curative effect is accurate, and the prescription is rigorous and reasonable. It has become a representative prescription for nourishing kidney yin. Dropping pills adopt solid dispersion technology, use polyethylene glycol withou...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/20A61K47/10A61P1/14A61P39/00
CPCA61K9/2031A61K36/076A61K36/40A61K36/65A61K36/71A61K36/804A61K36/884A61K36/8945A61K2236/333A61K2236/39A61K2236/50A61P1/14A61P39/00A61K2300/00
Inventor 朱小虎孙向前
Owner JIANGSU EHAI PHARMA CORP
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