55 results about "Liu Wei Di Huang" patented technology

Liuwei Dihuang Decoction extract, comprising 11.4-17% by weight of polysaccharides, and / or 1.85-2.27% by weight of total glycosides (morroniside, loganin, paeoniflorin) and / or 23.5-35.5% by weight of mannotriose, wherein Liuwei Dihuang Decoction is composed of six traditional Chinese medicines of Rehmannia glutinosa, Cornus officinalis, Chinese yam, Alisma, Paeonol and Poria cocos in a weight ratio of 8:4:4:3:3:3.

The invention relates to an on-line detection method of near infrared spectrum for production process of traditional Chinese medicine, pill of six ingredients with rehmannia. The on-line detection method comprises the following steps: (1) selection of a calibration set sample; (2) property determination of the calibration set sample; (3) near infrared absorption spectrometry determination of the calibration set sample; (4) establishment of a calibration model; and (5) property determination of an unknown sample, namely leading a near infrared absorption spectrum value of the unknown sample into the calibration model established in the step (4) and then obtaining the content of target ingredients in the unknown sample after model calculation. The on-line detection method has the advantagesof simpleness, correction and good ruggedness, application for on-line quality control of the pill of six ingredients with rehmannia, and capability of resolving the problems of long time consumption,low efficiency and the like of the traditional off-line detection in production process.

The invention provides a Liuwei dihuang pill small honeyed pill raw drug powder multi-index rapid detection method, which comprises: (1) collecting Liuwei dihuang pill small honeyed pill raw drug powders from different production batches; (2) determining the quality control indexes of the Liuwei dihuang pill small honeyed pill raw drug powder, wherein the quality control indexes comprise water content, paeoniflorin, loganin, and paeonol; (3) collecting the near infrared spectrum data of the Liuwei dihuang pill small honeyed pill raw drug powder; (4) selecting an near infrared spectrum modeling waveband, and carrying out spectrum pretreatment; (5) establishing an artificial neural network computing method based on main component analysis, and establishing a quantitation correction model between the near infrared spectrum characteristic information and the water content, the paeoniflorin content, the loganin content and the paeonol content in the Liuwei dihuang pill small honeyed pill raw drug powder; and (6) rapidly determining the water content, the paeoniflorin content, the loganin content and the paeonol content in the Liuwei dihuang pill small honeyed pill raw drug powder by using the established model. Compared to the traditional method, the established analysis method of the present invention is rapid and green.

The present invention is the new quality control method for Rehmanniae ointment of six ingredients. The medicine Rehmanniae ointment of six ingredients is prepared with six kinds of Chinese medicinal materials, including prepared rhizome of rehmannia, dogwood, Chinese yam, tree peony bark, tuckahoe and oriental water plantain. The quality control method includes the high efficiency liquid phase chromatographic process to measure the content of paeoniflorin and the thin-layer chromatographic process to identify dogwood, and the method is accurate and advanced.

The present invention provides a concentrated Liuwei dihuang pill preparation method. According to the method, the existing preparation method is improved so as to effectively improve component transfer rate and paste yield, save energy consumption and reduce active ingredient loss.

The invention discloses a Chewing tablet of 'Liuwei Dihuang' and its preparation, which has the advantages of quick release rate, high biological availability, good taste, accurate dosage, and easiness in administration and carrying. The method can be used for treating dizziness, tinnitus, hectic fever and perspire during sleep.

The invention provides Maca compositions, and a compound preparation and an application thereof. The invention provides the Maca zinc composition with a Maca powder and nutrition zinc as active ingredients. The invention provides the Maca-Liuweidihuang pill composition with a Maca powder and a Liuweidihuang pill extract as active ingredients. The invention provides the Maca-wolfberry-radix astragali composition with a Maca powder, radix astragali, wolfberry and soybean isoflavone as active ingredients. The invention provides the Maca-radix puerariae composition with a Maca powder, radix puerariae and raspberry as active ingredients. The series of compositions added with edible auxiliary materials can be made into tablets (pressed cadies) and capsules. The compositions are in matched combination according to respective functional characteristics, and have a series of functions of tonifying kidney, tonifying yang, relieving physical fatigue, treating prostatitis, treating climacteric syndromes and resisting depression.

The invention discloses a making method of concentrated Bolus of Six Drugs Including Rehmannia, which comprises the following steps: fetching prepared rehmannia root, Cornaceae, moutan bark, Dioscorea japonica, poria cocos wolf and Alismatales as raw materials; extracting paeonol from bark of peony root; adding dregs of a decoction, Cornaceae, prepared rehmannia root, poria cocos wolf and Alismataceae into water to boil; condensing filtrate into plaster; grinding Dioscorea japonica and residual Cornaceae powder into flour; sieving; blending evenly; blending the plaster, flour and paeonol evenly; pelletizing; drying; polishing; obtaining the plaster with relative density at 1. 38-1. 40 / 75 deg. c; controlling the dried pill weight at 0. 425g-0. 445g / pill and diameter at 8. 5-9. 2mm / pill; adding alcohol or disintegration agent to modify the drying technique. The invention converses 3 pills as norm as original 3g drug to satisfy the request of inner quality and appearance, which reduces the dosage for patient with convenient intake.

The invention relates to a method for producing a feed by using herb residues of liu-wei-di-huang pills through fermentation. A fermentation raw material mainly adopts the waste herb residues produced by extracting medicinal components from raw medicinal material liu-wei-di-huang pills and is subjected to solid fermentation culture by inoculating aspergillus niger, so that a plant fermented protein feed containing mycoproteins is obtained. The production technology disclosed by the invention is simple, and the cost is low; a produced product is safe and non-toxic; furthermore, after fermentation, the content of the proteins in the herb residues of the liu-wei-di-huang pills is effectively increased; the effects of the herb residues of liu-wei-di-huang pills is fully used; therefore, the feed has the health-protection effects of enhancing the immunity of animals, adjusting metabolism, promoting growth and improving the meat quality of the animals.

Liuwei Dihuang Pill is a Chinese medicinal preparation based on ancient prescription, but alisol, one of its ingredients has the side effect of causing nausea, emesis, dizziness, abdominalgia, myasthenia of limbs and other diseases. By substituting alisol with bark of boxthron-root, the invention provides another Liuwei Dihuang preparation for sustaining the action of body fluid reinforcing and kidney tonifying, and preventing adverse effects of alisol.

The invention relates to a Chinese medicinal preparation of Six-Ingredient Rehmannia Decoction and process for preparation which comprises grilling herbs of Six-Ingredient Rehmannia Decoction and concentrating to a concentration of 0.2-2g / ml, fermenting soybean milk 4-8 parts and filtering, charging soybean milk fermentation liquor into water grilling liquid, adjusting pH=6-10, inoculating photosynthetic bacterium into the decoction, fermenting under the temperature of 10-30 deg. C for 1-5 months, isolating the soup, extracting, refining and sterilizing.

The present invention relates to an osmotic pump controlled-release preparation of Liuwei Dihuangwan pills or its variant prescription extract. It is characterized by that it is formed from several portions of osmotic pump tablet core, coating film and medicine-releasing hole, in which the osmotic tablet core includes 5%-70% of Liuwei Dihuang or its variant prescription active extract and 5%-90% of auxiliary material capable of making active extract be easily released. The described extract is one kind selected from Liuwei Dihuang extract, Zhibai dihuang extract, Maiwei Dihuang extract, Gouju dihuang extract, Mingmu Dihuang extract and Guifu Dihuang extract. It can be made into tablet, capsule, suppository and other dosage forms, then made into various osmotic pump preparation.s

Ancient prescription liu-wei tonic pills frequently cause a plurality of untoward effects due to alisma orientale in compositions; and the dosage is large, and the treatment effect can only be achieved by taking 8 granules at a time, which can not meet the requirement of the China Pharmacopoeia Committee that 'only 2 granules are required for taking'. The invention relates to novel liu-wei tonic preparation, which is a novel medicine prepared by replacing the alisma orientale in preparation such as the liu-wei tonic pills and so on into cortex lycii radicis. The novel liu-wei tonic preparation adopts the CO2 supercutical fluid extraction method and utilizes manufacturing techniques such as the technology for gradient filtration and separation through an ultrafiltration membrane, improves the yield, avoids damage of high temperature on effective ingredients, has high bioavailability, and also can remove a plurality of impurities and ineffectual ingredients and greatly reduce the dosage. Because the novel liu-wei tonic preparation produced by any method can prepare various preparation types which are the same as the prior liu-wei tonic preparation, the homonymy phenomena of the novel medicine and the prior medicine can occur certainly, 'novel' is named before the prior name as for improved novel products, i.e. named as novel liu-wei tonic pills, novel liu-wei tonic tablets, novel liu-wei tonic capsules and so on.

The invention belongs to the field of traditional Chinese medicine preparations and particularly relates to a preparation method of Liuwei Dihuang pills. The Liuwei Dihuang pills are made from 120g of prepared rehmannia root, 60g of common Macrocarpium fruit, 45g of root-bark of tree peony, 60g of common yam rhizome, 45g of Indian bread and 45g of rhizome of oriental water plantain. The Liuwei Dihuang pills are prepared with macroporous resin, cation exchange resin and anion exchange resin, so that contents are greatly increased and less usage is required. The invention further provides application of the Liuwei Dihuang pills in the preparation of medicaments for inhibiting proliferation of mouse embryonic fibroblast NIH3T3.

The invention relates to a preparation method of pepsin and trypsin treated Liuwei Dihuang composite micro-ecological oral liquid. The preparation method comprises the following steps: (1) crushing Liuwei Dihuang pill raw materials, adding water, and mixing uniformly to prepare raw material serous fluid; (2) adding acid into the raw material serous fluid to adjust the pH value, and adding pepsin for treatment, thereby preparing pepsin treated serous fluid; (3) adding trypsin into the pepsin treated serous fluid for treatment to prepare the pepsin and trypsin treated serous fluid; and (4) inoculating bifidobacteria and lactobacillus plantarum to obtain the pepsin treated Liuwei Dihuang composite micro-ecological oral liquid. The pepsin and trypsin treated Liuwei Dihuang composite micro-ecological oral liquid prepared by the preparation method provided by the invention is relatively small in side effect, and is palatable in sweet and sour tastes; and by virtue of practical application, after being taken for a long time, the pepsin and trypsin treated Liuwei Dihuang composite micro-ecological oral liquid not only can achieve a treatment effect of Liuwei Dihuang pills but also greatly reduces the side effects causing stomach cold and digestion obstruction.

A large-dosage dripping pill of six drugs including rehmannia is prepared from 6 Chinese-medicinal materials including prepared rehmannia root, dogwood fruit, tree peony bark, yam, tuckahoe and alismatis rhizome. Its preparing process is also disclosed.

The invention relates to a quality control method of a traditional Chinese medicine compound preparation, in particular to a prescription analysis and quality analysis method of six-ingredient rehmannia pill based on a high performance liquid chromatography-diode array detection technology (HPLC-DAD). The method comprises the following two parts: firstly, respectively identifying the characteristic peaks of six prescription decoction pieces in a plurality of wavelength modes by utilizing the difference of ultraviolet absorption spectra of chemical components of the six decoction pieces in the six-ingredient rehmannia pill, and establishing a six-ingredient rehmannia pill prescription analysis method based on the characteristic peaks of the decoction pieces; and secondly, developing a quality marker (Q-Marker) of the six-ingredient decoction pieces on the basis of the characteristic peaks of the decoction pieces, and analyzing the current quality situation of the six decoction pieces in the six-ingredient rehmannia pill by using the Q-Marker. The prescription analysis and quality analysis method provided by the invention is simple and efficient, and lays a scientific foundation for the overall quality control of the six-ingredient rehmannia pill.

A preparation method of six-ingredient rehmannia capsules. The invention relates to a new method of preparation of a traditional Chinese medicine compound preparation. The six-ingredient rehmannia capsules comprise of six raw material medicines: prepared rehmannia roots, paeonia suffruticosa, Chinese yam, cornus officinalis, rhizoma alismatis and poria cocos. The preparation method includes preparation of poria cocos micropowder, the preparation of a water extract of the poria cocos, the preparation of an alcohol extract of the cornus officinalis, the preparation of a paeonol [beta]-cyclodextrine inclusion complex, the preparation of a water extract of the medicines, and the filling of the capsules. By means of an ultrasonic extraction method, active ingredients in cells of the medicines can be dissolved out rapidly and the active ingredients are free from being destroyed under violent conditions so that high extraction ratios of the active ingredients is high, an extraction time is short and energy resources are saved. By means of a jet mill for ultrasonic kinetic energy jet milling, granules of the medicines are easy to absorb by human bodies. By means of a paeonol [beta]-cyclodextrine including technology, influences caused by light, oxygen and hydrolysis conditions are effectively avoided and stabilities of volatile ingredients are improved. Not only are retaining indexes of the volatile ingredients in the preparation effectively increased, but also thick pungent odors are covered better and the capsules are more convenient to take.

Six-ingredient rehmannia pill is a famous ancient medicine which is applied for almost a thousand years, and is also a popular drug which is often taken by people for a long term in pursuit of health care and body building, however, alisma in the raw material medicine can cause gastroenteritis, nausea, vomiting, dizziness, eye faint, abdominal pain, diarrhea, limb weakness, loss of appetite, itching, angioedema, allergic skin rashes or even respiratory paralysis and other poisoning symptoms. The ancient and modern medical literature points out that the alisma can not be taken for a long term or with a large amount at early time, or else, the long-term taking of the alisma can also cause sever side effects such as kidney toxicity and thus resulting in acute tubular necrosis and the like. The traditional Chinese medicine phellodendron has the function of reducing renal fire of the alisma in the six-ingredient rehmannia pill. The six-ingredient rehmannia pill is used to replace the alisma, is improved into a new six-ingredient rehmannia pill, not only can maintain the functions of nourishing yin and tonifying the kidney of the ancient six-ingredient rehmannia pill, but also can avoid adverse reactions caused by the use of the alisma, thereby being conducive to improving the safety of the medicine and being capable of obtaining a considerable amount of market share in the competition with the original six-ingredient rehmannia pill.

The invention discloses a preparation method of Liuwei Dihuang pills. The Liuwei Dihuang pills comprise the following medicinal effective components in parts by weight: 160 parts of prepared radix rehmanniae, 80 parts of wine-prepared fructus corni, 60 parts of moutan bark, 80 parts of Chinese yam, 60 parts of poria cocos and 60 parts of rhizoma alismatis. The preparation method of the pills comprises the following steps: (1) preparing medicinal powder: taking the prepared radix rehmanniae, the fructus corni, the moutan bark, the Chinese yam, the poria cocos and the rhizoma alismatis, crushing, sieving and uniformly mixing to obtain the medicinal powder; (2) preparing an adhesive: taking glycerol into a container, adding medicinal carboxymethyl cellulose salt, uniformly stirring, sealing, and heating until the carboxymethyl cellulose salt is completely swelled, so as to prepare the adhesive for later use; and (3) preparing the pills: adding the adhesive accounting for 25-50% of the total amount of the prepared medicine into a paste powder mixture, uniformly mixing, and pelleting to obtain the Liuwei Dihuang pills. According to the invention, the prepared Liuwei Dihuang pills have the beneficial effects that ethanol, refined honey and water are not used as adhesives, the prepared Liuwei Dihuang pills do not need to be subjected to a drying process, the volatile component paeonol in the finished product is low in loss, the content is relatively high, the dispersion time limit is short, and the quality is stable and controllable.

A Liuwei Dihuang decoction (Glucoside active site LWD-b) extract includes, by weight of extract, 12.5-15.3 weight % total glycosides (morroniside, loganin, paeoniflorin), wherein the Liuwei Dihuang decoction is prepared by rehmannia, dogberry, Chinese potato, rhizoma alismatis, cortex moutan and tuckahoe with a weight proportion of 8:4:4:3:3:3.

The invention discloses a preparation method of Liuweidihuang pills. The preparation method adopts a diaphragm press filtration cycle extraction separation integrated technology to extract active ingredients of prescription drugs. The preparation method simplifies a process flow, shortens greatly a production period, saves energy consumption, is beneficial for environmental protection and dreg utilization, and improves greatly an active ingredient recovery rate.

The invention provides a Liuwei Dihuang decoction total extract composition and a preparation method and application thereof to preparation of drugs for treating heart, brain and testis complications caused by stress response. The composition comprises the active pharmaceutical ingredients including radix rehmanniae praeparata, prepared fructus corni, Chinese yam, rhizoma alismatis, cortex moutan and Indian buead in a weight ratio of 8:4:4:3:3:3. The composition is characterized in that the composition comprises an essential oil beta-cyclodextrin inclusion compound ingredient, a polysaccharide ingredient, a glucoside ingredient and a fat soluble ingredient of a Liuwei Dihuang decoction total extract. The composition and the preparation method have the following beneficial effects: the defect that the fat soluble active ingredients of the Liuwei Dihuang decoction total extract are neglected in the prior art is overcome; the more complete ingredient composition of the Liuwei Dihuang decoction total extract is obtained through the extraction process; and the composition is possibly used to treat the heart, brain and testis complications caused by stress response.

The invention relates to flour containing traditional Chinese medicine health-care components and a preparation method of the flour. The flour is characterized by being prepared from the following rawmaterials in parts by weight: 300-350 parts of flour, 30-50 parts of corn flour, 10-12 parts of radix rehmanniae, 3-5 parts of poria cocos, 2-3 parts of rhizoma alismatis, 3-5 parts of asiatic cornelian cherry fruits, 6-9 parts of Chinese yams, 2-3 parts of cortex moutan, 1-2 parts of chrysanthemums, 10-12 parts of Chinese wolfberry fruits, 3-5 parts of green tea, 2-3 parts of Chinese chestnut leaves, 2-3 parts of prunus humilis bunge leaves, and 2-3 parts of pseudostellaria maximowicziana. The raw materials contain components of a traditional Chinese medicine namely pills of six drugs with rehmannia, and besides, the chrysanthemums, the Chinese wolfberry fruits, the green tea and the like are added, so that the formula has the effects of nourishing kidney yin, clearing and reducing deficient fire and improving immunity, has a certain function of removing toxicity, can prevent mutation, can be eaten for a long term, and is beneficial for human health.

The invention relates to a quantitative determination method of pills of six ingredients with rehmannia, and a preparation method and application thereof. The adopted technical scheme is as follows: each millilitre of the contrast Chinese patent medicine extract of the pills of six ingredients with rehmannia contains 16.71-66.82 mu g of 5-hydroxymethylfurfural, 30.56-122.22 mu g of mrroniside, 19.52-78.06 mu g of loganin, 12.71-50.84 mu g of paeoniflorin, and 40.27-161.06 mu g of paeonol. The content determination of the pills of six ingredients with rehmannia is carried out by taking the contrast Chinese patent medicine extract of the pills of six ingredients with rehmannia provided by the invention as the standard substance and adopting a high-erformance liquid chromatography; therefore, the method is capable of simultaneously controlling a plurality of components, simplifying a checkout process and greatly reducing checkout cost and meets with the technology development tendency in the traditional Chinese checkout field; furthermore, the preparation method of the contrast extract is simple and convenient and is beneficial to being popularized and applied and has strong practicability.

The invention relates to a Chinese medicinal preparation of Six-ingredient Rehmannia Pills, which comprises six-ingredient rehmannia extract, pharmaceutical carrier system comprising grease substance and an surface active agent system. The medicament has fine physical stability, chemical stability and high medicament dissolving property.

The invention provides a traditional Chinese medicine composition used for treating blepharospasm. The traditional Chinese medicine composition is obtained through improvement based on main ingredients of Liuwei Dihuang pills and comprises rehmannia root, common macrocarpium fruit, rhizoma dioscoreae, oriental waterplantain rhizome, tree peony bark, Indian buead, tall gastrodia tuber, spina date seed, tuber fleeceflower stem, rhizome of drug sweetflag, chrysanthemum, barbary wolfberry fruit, radix astragali, Chinese angelica, antelope horn powder, gambir plant and red paeony root. The medicine has the functions of nourishing kidney yin, protecting nerves and replenishing vital essence to improve eyesight, is short in medication time, is convenient to use and has high cure rate and low recurrence rate.

The invention belongs to the field of pharmacy and relates to a preparation method of applying homogenization technology in traditional Chinese medicine dropping pills, and particularly relates to a preparation method of using the homogenization technology in Liu Wei Di Huang dropping pills. In the method, a melt of the Liu Wei Di Huang dropping pills can be completely ground uniformly, so that problems of rough surfaces and non-uniform color of the pills are solved, and quality of the Liu Wei Di Huang dropping pills is improved. The method is convenient and practical and has convenience in product quality control.

The invention discloses a nano microcapsule for six ingredients with rehmannia and a preparation process thereof. The preparation process comprises the following steps of: taking the traditional pills for six ingredients with the rehmannia as a basis, adopting a multilevel dynamic hot reflux method for extraction and concentration of radix rehmanniae preparata, Poria cocos and rhizoma alismatis; carrying out nano-level crushing on dogwood, tree peony bark and yam; and uniformly mixing the nano fine powder and concentrated liquor according to certain proportion, carrying out freezing or spray-drying treatment, preparing the nano microcapsule, and finally adopting a corresponding preparation technology to prepare into a dosage form applicable on clinic. The process has the advantages of simple operation, short process flow, easy control of parameters, low cost, no toxic and side effects caused by organic reagents and the like. The nano microcapsule for six ingredients with the rehmannia can be directly used, and also can be used as a drug intermediate. In the nano microcapsule, the drug effect can be obviously delayed, the administration times and amount can be reduced, and the toxic and side effect caused by the traditional drug is reduced or eliminated. The nano microcapsule is concentrated by more than three times compared with the existing nano microcapsule product for six ingredients with the rehmannia on the market, and the total daily dosage can be reduced by 3-6 times compared with the traditional products such as the concentrated six ingredients with the rehmannia and the like.