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Medicament of 'Liu Wei Di Huang' and preparation method thereof

A technology of Liuwei Rehmannia glutinosa and medicament, applied in the field of Liuwei Rehmannia glutinosa medicament, can solve the problems of no disclosure of beneficial effects, shortened treatment time, no test results and the like

Inactive Publication Date: 2006-10-04
JILIN SIHUAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent application CN1466970 discloses a preparation method of Liuwei Dihuang Nano Oral Liquid. Although the invention believes that its curative effect is more significant or shortens the treatment time, it does not give specific test results
Chinese patent CN141371 discloses a production process of Liuwei Dihuang Capsules, which extracts and concentrates the prescribed medicinal materials respectively, and extracts them with macroporous resins to fully retain the active ingredients. Although the production method of the invention is simple and Easy to do, the drug has been further concentrated and refined, but its pharmacodynamic behavior has not been made public
The patent (CN1569191) applied by Jiangxi Tianshikang Traditional Chinese Medicine Co., Ltd. discloses a Liuwei Dihuang orally disintegrating tablet and its preparation method. The orally disintegrating tablet is suitable for pharmaceutical preparations with a small dose. The basic requirement is that the drug disintegrate Fast solution, good taste, but the invention does not disclose these basic beneficial effects

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  • Medicament of 'Liu Wei Di Huang' and preparation method thereof
  • Medicament of 'Liu Wei Di Huang' and preparation method thereof

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preparation example Construction

[0087] Embodiment 1——Preparation of Liuwei Dihuang Extract

[0088] The dosage of raw medicinal materials is as follows:

[0089] Rehmannia glutinosa 160 parts

[0090] Cornus officinalis (made) 80 parts

[0091] Moutan bark 60 parts

[0092] Yam 80 servings

[0093] Poria cocos 60 parts

[0094] Alisma 60 parts.

[0095]Preparation method: Distill the above six flavors and peony bark to extract volatile oil, and collect the distilled aqueous solution in another device; reflux extraction with 70% ethanol for two times, each time for 2 hours, combine the extracts, filter, and reserve the filtrate; Rehmannia glutinosa and yam Alisma and Alisma are decocted twice, the first time is 2 hours, the second time is 1 hour, the decoction is combined, filtered, the filtrate is combined with the above aqueous solution, and concentrated under reduced pressure to a clear liquid with a relative density of 1.15-1.20 (50°C). paste, let it cool, add ethanol to make the alcohol content rea...

Embodiment 2—— 6

[0097] Embodiment 2——Preparation of Liuwei Dihuang Extract

[0098] The dosage of raw medicinal materials is as follows:

[0099] Rehmannia glutinosa 128g

[0100] Cornus officinalis (made) 96g

[0101] Moutan bark 72g

[0102] Yam 96g

[0103] Poria cocos 72g

[0104] Alisma 72g.

[0105] Preparation method: add rehmannia glutinosa, dogwood (made), moutan cortex, Chinese yam, poria cocos, and Alisma sativa, decoct six herbs, combine the decoction, filter, let stand, take the supernatant and concentrate it under reduced pressure to form a clear ointment, dry , crushed into fine powder, and the content of paeonol in it was determined to obtain Liuwei Dihuang extract.

[0106] The results of multiple preparations showed that the content of paeonol was 11.32%±1.24% (n=5, weight percentage).

Embodiment 3—— 6

[0107] Embodiment 3——Preparation of Liuwei Dihuang Extract

[0108] The dosage of raw medicinal materials is as follows:

[0109] Rehmannia glutinosa 192g

[0110] Cornus officinalis (made) 64g

[0111] Moutan bark 48g

[0112] Yam 64g

[0113] Poria cocos 48g

[0114] Alisma 48g.

[0115] Preparation method: crush 30%~40% weight of Poria cocos into fine powder, add water to decoct the rest, concentrate the decoction into a thick paste; add ethanol to extract Cornus officinalis, concentrate the extract into paste, and use dregs for later use; Moutan cortex is steam distilled , adding hydrochloric acid solution to the distillate to precipitate crystallization; the distilled aqueous solution, moutan bark dregs, dogwood dregs, rehmannia glutinosa, yam, and Alisma are decocted with water, the filtrate is adsorbed by macroporous resin, ethanol is eluted, and ethanol is recovered and decocted. Concentrate into paste, add Poria thick paste, Cornus officinalis paste and Poria fi...

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Abstract

The invention relates to a Chinese medicinal preparation of Six-ingredient Rehmannia Pills, which comprises six-ingredient rehmannia extract, pharmaceutical carrier system comprising grease substance and an surface active agent system. The medicament has fine physical stability, chemical stability and high medicament dissolving property.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine medicaments, in particular, the invention relates to a Liuwei Dihuang medicament and a preparation method thereof. Background technique [0002] The prescription of Liuwei Dihuang Wan first appeared in the Song Dynasty. It was made by Qian's Shenqi Wan from the "Synopsis of the Golden Chamber" by Zhang Zhongjing, the medical sage of the Eastern Han Dynasty, minus Fuzi and Guizhi. It is a classic prescription in the treasure house of traditional Chinese medicine. Among them, the six traditional Chinese medicines and their approximate proportions are: 160 parts of Rehmannia glutinosa, 80 parts of Cornus officinalis (made), 60 parts of Cortex Moutan, 80 parts of Chinese yam, 60 parts of Poria cocos, and 60 parts of Alisma. [0003] At present, there are many kinds of preparations made from Liuwei Dihuang Chinese medicine, which have been reviewed by the Chinese drug administration departme...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/48A61P1/14
Inventor 杨尚华晏四平
Owner JILIN SIHUAN PHARM CO LTD
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