Preparation method of six-ingredient rehmannia capsules

Abstract

A preparation method of six-ingredient rehmannia capsules. The invention relates to a new method of preparation of a traditional Chinese medicine compound preparation. The six-ingredient rehmannia capsules comprise of six raw material medicines: prepared rehmannia roots, paeonia suffruticosa, Chinese yam, cornus officinalis, rhizoma alismatis and poria cocos. The preparation method includes preparation of poria cocos micropowder, the preparation of a water extract of the poria cocos, the preparation of an alcohol extract of the cornus officinalis, the preparation of a paeonol [beta]-cyclodextrine inclusion complex, the preparation of a water extract of the medicines, and the filling of the capsules. By means of an ultrasonic extraction method, active ingredients in cells of the medicines can be dissolved out rapidly and the active ingredients are free from being destroyed under violent conditions so that high extraction ratios of the active ingredients is high, an extraction time is short and energy resources are saved. By means of a jet mill for ultrasonic kinetic energy jet milling, granules of the medicines are easy to absorb by human bodies. By means of a paeonol [beta]-cyclodextrine including technology, influences caused by light, oxygen and hydrolysis conditions are effectively avoided and stabilities of volatile ingredients are improved. Not only are retaining indexes of the volatile ingredients in the preparation effectively increased, but also thick pungent odors are covered better and the capsules are more convenient to take.

Description

technical field [0001] The invention relates to a new method for preparing a traditional Chinese medicine compound preparation, in particular to a method for preparing a well-known Chinese patent medicine Liuwei Dihuang Capsule. Background technique [0002] Liuwei Dihuang Capsule is a traditional Chinese medicine preparation recorded in the Pharmacopoeia of the People's Republic of China. The prescription is composed of 6 herbs, Rehmannia glutinosa, Cortex Moutan, Chinese yam, Cornus officinalis, Alisma, and Poria, which have the effect of nourishing yin and tonifying kidney. For deficiency of kidney yin, dizziness and tinnitus, soreness of the waist and knees, hot flashes due to bone steaming, night sweats and other diseases. [0003] The current preparation method of Liuwei Dihuang Capsules is to take part of Poria cocos (1 / 5) from the above-mentioned 6 flavors and pulverize into fine powder, and decoct the remaining part and the remaining Poria cocos in water three ti...

AI Technical Summary

Problems solved by technology

[0005] Most of the above-mentioned preparation methods are to add part of the original medicinal materials of Poria cocos into the preparation by ordinary pulverization, so that the preparation has large particles of medicinal materials, poor absorption, Slow action and other disadvantages; in these preparation methods, the active ingredients of medicinal materials are mostly extracted by reflux extraction or water decoction method and ordinary concentration, baking and drying method, because the extract is decocted, dried and heated for a long time, some heat Unstable active ingredients are easily destroyed, and the extraction rate of active ingredients is not high. In addition, long-term heating in the process consumes energy and pollutes the environment. It is time-consuming and laborious, which is not conducive to the modernization of traditional Chinese medicine production.

Although the literature has a modern technology for extracting paeonol from Moutan cortex with supercritical C02, its processing capacity is small and the cost is high. It is not easy to use in production.

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