Nano microcapsule for six ingredients with rehmannia and preparation process thereof

A Liuwei Rehmannia, preparation technology, applied in the direction of microcapsules, nanocapsules, anti-toxic agents, etc., can solve the problems of unsuitable preparation of polysaccharides, large dosage, inconvenience, etc., and achieve increased dissolution rate, short process flow, and simple operation Effect

Inactive Publication Date: 2012-05-02
HENAN UNIVERSITY OF TECHNOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Liuwei Dihuang Yuanfang uses the raw powder of medicinal materials as medicine, and the dosage is large, which is extremely inconvenient
However, the macroporous resin adsorption method is not suitable for the preparation of polysaccharides. Although the drug can be concentrated, polysaccharides with important pharmacological effects are removed.

Method used

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  • Nano microcapsule for six ingredients with rehmannia and preparation process thereof
  • Nano microcapsule for six ingredients with rehmannia and preparation process thereof
  • Nano microcapsule for six ingredients with rehmannia and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Add 1408 grams of Rehmannia glutinosa, 528 grams of Poria cocos, and 538 grams of Alisma, add 10 L of water and put it into the hot reflux extraction and concentration equipment, T=90°C-95°C, reflux extraction for 3-4 hours, filter the extract, and set aside. 704 grams of Cornus officinalis, 528 grams of Cortex Moutan, and 704 grams of Chinese yam are conventionally crushed, and after passing through an 80-mesh sieve, they are put into a superfine pulverizer for superfine or nanoscale pulverization. The spindle speed is 300r / min-350r / min. Sieve above 1250 mesh, set aside. The above extract and nano-scale fine powder are uniformly mixed at a ratio of 0.5:1 to a paste and set aside. Pre-cool the Liuweidihuang nano suspension at -20°C for 30 minutes, put it into a freeze vacuum dryer, set the cold trap temperature at -50°C to 40°C, and vacuum at 90-120Pa, and dry for 6h-12h. The dried sample is pulverized, ground and sieved to obtain Liuwei Dihuang nano-microcapsules. wo...

Embodiment 2

[0048] Add 1408 grams of Rehmannia glutinosa, 528 grams of Poria cocos, and 538 grams of Alisma, add 10 L of water and put it into the hot reflux extraction and concentration equipment, T=96°C-98°C, reflux extraction for 2 hours, filter the extract, and set aside. 704 grams of dogwood, 528 grams of peony cortex, and 704 grams of yam are conventionally crushed, passed through an 80-mesh sieve, and put into a superfine pulverizer for nano-scale crushing. The spindle speed is 350r / min-400r / min. Sieve, set aside. The above extract and nano-scale fine powder are uniformly mixed at a ratio of 1:0.5 to a suspension or paste, and set aside. Pre-cool the above-mentioned Liuwei Dihuang nano-suspension at -20°C for 24 hours, put it into a freeze-vacuum dryer, set the temperature of the cold trap at -50°C--40°C, and dry it for 20h-24h at a vacuum degree of 7.90-30.20Pa. After crushing, grinding and sieving, Liuwei Dihuang nano-microcapsules are obtained. Works best.

Embodiment 3

[0050] Add 1408 grams of Rehmannia glutinosa, 528 grams of Poria cocos, and 538 grams of Alisma, add 10 L of water and put it into the hot reflux extraction and concentration equipment, T=98°C-100°C, reflux extraction for 1 hour, filter the extract, and set aside. 704 grams of dogwood, 528 grams of peony bark, and 704 grams of Chinese yam are conventionally crushed, passed through an 80-mesh sieve, and put into a superfine pulverizer for nano-scale crushing. The spindle speed is 400r / min-450r / min. Sieve, set aside. The above extract and nano-scale fine powder are uniformly mixed at a ratio of 20:1 to form a suspension and set aside. Pre-cool the above-mentioned Liuwei Dihuang nano suspension at -20°C for 4 hours, put it into a freeze-vacuum dryer, set the temperature of the cold trap at -50°C-40°C, and vacuum degree of 60-80Pa, dry it for 6h-24h, and dry the dried sample After crushing, grinding and sieving, Liuwei Dihuang nano-microcapsules are obtained. works well.

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Abstract

The invention discloses a nano microcapsule for six ingredients with rehmannia and a preparation process thereof. The preparation process comprises the following steps of: taking the traditional pills for six ingredients with the rehmannia as a basis, adopting a multilevel dynamic hot reflux method for extraction and concentration of radix rehmanniae preparata, Poria cocos and rhizoma alismatis; carrying out nano-level crushing on dogwood, tree peony bark and yam; and uniformly mixing the nano fine powder and concentrated liquor according to certain proportion, carrying out freezing or spray-drying treatment, preparing the nano microcapsule, and finally adopting a corresponding preparation technology to prepare into a dosage form applicable on clinic. The process has the advantages of simple operation, short process flow, easy control of parameters, low cost, no toxic and side effects caused by organic reagents and the like. The nano microcapsule for six ingredients with the rehmannia can be directly used, and also can be used as a drug intermediate. In the nano microcapsule, the drug effect can be obviously delayed, the administration times and amount can be reduced, and the toxic and side effect caused by the traditional drug is reduced or eliminated. The nano microcapsule is concentrated by more than three times compared with the existing nano microcapsule product for six ingredients with the rehmannia on the market, and the total daily dosage can be reduced by 3-6 times compared with the traditional products such as the concentrated six ingredients with the rehmannia and the like.

Description

technical field [0001] The invention relates to a nano-microcapsule of Liuwei Dihuang and a preparation process thereof, belonging to the technical field of preparation of dosage forms of traditional Chinese medicines. Background technique [0002] Liuwei Dihuang is composed of six traditional Chinese medicines of Rehmannia glutinosa, Cornus officinalis, Chinese yam, Alisma, Moutan cortex and Poria cocos. Liuwei medicinal materials contain polysaccharides, glycosides, terpenes and other active ingredients. Studies have shown that the acidic polysaccharide CA4-3 in Liuwei Dihuang can directly act on B cells and improve the body's immunity. The polysaccharide PFCAIII in Cornus officinalis can effectively inhibit the oxidation of vegetable oil and has the effect of scavenging free radicals. The terpene ursolic acid in Cornus officinalis has the effect of lowering blood fat and blood sugar. Paeonol in Cortex Moutan has been widely used in analgesia and anti-inflammation after ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/51A61P1/14A61P35/00A61P37/04A61P39/06A61P9/12A61P3/10A61P13/12A61P15/12A61P11/00
Inventor 王卫国赵永亮侯启昌崔羽佳李鹏古亚楠孟甜甜张鹏丁金聚
Owner HENAN UNIVERSITY OF TECHNOLOGY
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