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35 results about "Liu-wei-di-huang wan" patented technology

Liu Wei Di Huang Wan, also known as Liuwei Dihuang teapills (simplified Chinese: 六味地黄丸; traditional Chinese: 六味地黃丸; pinyin: liùwèi dìhuáng wán) or Six Flavor Rehmanni, is a prescription (方剂 fāng jì) in traditional Chinese medicine and pharmacy to treat yin deficiency. In Japanese kampo, it is known as "Rokumi-gan" (六味丸 ろくみがん) (it is also known as Kampo #87). It is commonly made into Chinese patent medicine.

On-line detection method of near infrared spectrum for production process of traditional Chinese medicine, pill of six ingredients with rehmannia

The invention relates to an on-line detection method of near infrared spectrum for production process of traditional Chinese medicine, pill of six ingredients with rehmannia. The on-line detection method comprises the following steps: (1) selection of a calibration set sample; (2) property determination of the calibration set sample; (3) near infrared absorption spectrometry determination of the calibration set sample; (4) establishment of a calibration model; and (5) property determination of an unknown sample, namely leading a near infrared absorption spectrum value of the unknown sample into the calibration model established in the step (4) and then obtaining the content of target ingredients in the unknown sample after model calculation. The on-line detection method has the advantagesof simpleness, correction and good ruggedness, application for on-line quality control of the pill of six ingredients with rehmannia, and capability of resolving the problems of long time consumption,low efficiency and the like of the traditional off-line detection in production process.
Owner:EAST CHINA UNIV OF SCI & TECH

Liuwei dihuang pill small honeyed pill raw drug powder multi-index rapid detection method

The invention provides a Liuwei dihuang pill small honeyed pill raw drug powder multi-index rapid detection method, which comprises: (1) collecting Liuwei dihuang pill small honeyed pill raw drug powders from different production batches; (2) determining the quality control indexes of the Liuwei dihuang pill small honeyed pill raw drug powder, wherein the quality control indexes comprise water content, paeoniflorin, loganin, and paeonol; (3) collecting the near infrared spectrum data of the Liuwei dihuang pill small honeyed pill raw drug powder; (4) selecting an near infrared spectrum modeling waveband, and carrying out spectrum pretreatment; (5) establishing an artificial neural network computing method based on main component analysis, and establishing a quantitation correction model between the near infrared spectrum characteristic information and the water content, the paeoniflorin content, the loganin content and the paeonol content in the Liuwei dihuang pill small honeyed pill raw drug powder; and (6) rapidly determining the water content, the paeoniflorin content, the loganin content and the paeonol content in the Liuwei dihuang pill small honeyed pill raw drug powder by using the established model. Compared to the traditional method, the established analysis method of the present invention is rapid and green.
Owner:JIUZHITANG

Concentrated Liuwei dihuang pill preparation method

The present invention provides a concentrated Liuwei dihuang pill preparation method. According to the method, the existing preparation method is improved so as to effectively improve component transfer rate and paste yield, save energy consumption and reduce active ingredient loss.
Owner:JIUZHITANG

Maca compositions, and compound preparation and application thereof

The invention provides Maca compositions, and a compound preparation and an application thereof. The invention provides the Maca zinc composition with a Maca powder and nutrition zinc as active ingredients. The invention provides the Maca-Liuweidihuang pill composition with a Maca powder and a Liuweidihuang pill extract as active ingredients. The invention provides the Maca-wolfberry-radix astragali composition with a Maca powder, radix astragali, wolfberry and soybean isoflavone as active ingredients. The invention provides the Maca-radix puerariae composition with a Maca powder, radix puerariae and raspberry as active ingredients. The series of compositions added with edible auxiliary materials can be made into tablets (pressed cadies) and capsules. The compositions are in matched combination according to respective functional characteristics, and have a series of functions of tonifying kidney, tonifying yang, relieving physical fatigue, treating prostatitis, treating climacteric syndromes and resisting depression.
Owner:江苏海王健康生物科技有限公司

Method of preparing concentrated pill of six ingredients with rehmannia

ActiveCN101129642AOvercome the shortcoming of small weight differenceReduce dosageDigestive systemPill deliveryLiu Wei Di HuangAdditive ingredient
The invention discloses a making method of concentrated Bolus of Six Drugs Including Rehmannia, which comprises the following steps: fetching prepared rehmannia root, Cornaceae, moutan bark, Dioscorea japonica, poria cocos wolf and Alismatales as raw materials; extracting paeonol from bark of peony root; adding dregs of a decoction, Cornaceae, prepared rehmannia root, poria cocos wolf and Alismataceae into water to boil; condensing filtrate into plaster; grinding Dioscorea japonica and residual Cornaceae powder into flour; sieving; blending evenly; blending the plaster, flour and paeonol evenly; pelletizing; drying; polishing; obtaining the plaster with relative density at 1. 38-1. 40 / 75 deg. c; controlling the dried pill weight at 0. 425g-0. 445g / pill and diameter at 8. 5-9. 2mm / pill; adding alcohol or disintegration agent to modify the drying technique. The invention converses 3 pills as norm as original 3g drug to satisfy the request of inner quality and appearance, which reduces the dosage for patient with convenient intake.
Owner:TAIJI GRP CHONGQING NO 2 CHINESE MEDICINE FACTORY

Contrast Chinese patent medicine extract of pills of six ingredients with rehmannia, and preparation method and application thereof

The invention relates to a quantitative determination method of pills of six ingredients with rehmannia, and a preparation method and application thereof. The adopted technical scheme is as follows: each millilitre of the contrast Chinese patent medicine extract of the pills of six ingredients with rehmannia contains 16.71-66.82 mu g of 5-hydroxymethylfurfural, 30.56-122.22 mu g of mrroniside, 19.52-78.06 mu g of loganin, 12.71-50.84 mu g of paeoniflorin, and 40.27-161.06 mu g of paeonol. The content determination of the pills of six ingredients with rehmannia is carried out by taking the contrast Chinese patent medicine extract of the pills of six ingredients with rehmannia provided by the invention as the standard substance and adopting a high-erformance liquid chromatography; therefore, the method is capable of simultaneously controlling a plurality of components, simplifying a checkout process and greatly reducing checkout cost and meets with the technology development tendency in the traditional Chinese checkout field; furthermore, the preparation method of the contrast extract is simple and convenient and is beneficial to being popularized and applied and has strong practicability.
Owner:LIAONING PROVINCE INST FOR FOOD & DRUG CONTROL

Method for producing feed by using herb residues of liu-wei-di-huang pills through fermentation

The invention relates to a method for producing a feed by using herb residues of liu-wei-di-huang pills through fermentation. A fermentation raw material mainly adopts the waste herb residues produced by extracting medicinal components from raw medicinal material liu-wei-di-huang pills and is subjected to solid fermentation culture by inoculating aspergillus niger, so that a plant fermented protein feed containing mycoproteins is obtained. The production technology disclosed by the invention is simple, and the cost is low; a produced product is safe and non-toxic; furthermore, after fermentation, the content of the proteins in the herb residues of the liu-wei-di-huang pills is effectively increased; the effects of the herb residues of liu-wei-di-huang pills is fully used; therefore, the feed has the health-protection effects of enhancing the immunity of animals, adjusting metabolism, promoting growth and improving the meat quality of the animals.
Owner:HUNAN UNIV OF CHINESE MEDICINE

Formulation with six ingredients containing rehmanniae

Liuwei Dihuang Pill is a Chinese medicinal preparation based on ancient prescription, but alisol, one of its ingredients has the side effect of causing nausea, emesis, dizziness, abdominalgia, myasthenia of limbs and other diseases. By substituting alisol with bark of boxthron-root, the invention provides another Liuwei Dihuang preparation for sustaining the action of body fluid reinforcing and kidney tonifying, and preventing adverse effects of alisol.
Owner:吴开敏

Technique for preparing new preparation of six ingredients with rehmannia

Ancient prescription liu-wei tonic pills frequently cause a plurality of untoward effects due to alisma orientale in compositions; and the dosage is large, and the treatment effect can only be achieved by taking 8 granules at a time, which can not meet the requirement of the China Pharmacopoeia Committee that 'only 2 granules are required for taking'. The invention relates to novel liu-wei tonic preparation, which is a novel medicine prepared by replacing the alisma orientale in preparation such as the liu-wei tonic pills and so on into cortex lycii radicis. The novel liu-wei tonic preparation adopts the CO2 supercutical fluid extraction method and utilizes manufacturing techniques such as the technology for gradient filtration and separation through an ultrafiltration membrane, improves the yield, avoids damage of high temperature on effective ingredients, has high bioavailability, and also can remove a plurality of impurities and ineffectual ingredients and greatly reduce the dosage. Because the novel liu-wei tonic preparation produced by any method can prepare various preparation types which are the same as the prior liu-wei tonic preparation, the homonymy phenomena of the novel medicine and the prior medicine can occur certainly, 'novel' is named before the prior name as for improved novel products, i.e. named as novel liu-wei tonic pills, novel liu-wei tonic tablets, novel liu-wei tonic capsules and so on.
Owner:吴开敏

Rehmannia-root preparation

The invention adds Chinese Angelica and Danshen into the original prescription of traditonal Liuwei dihuang pills, and prepares them into medicines in related forms, having functions of nourishing Yin and tonifying kidney, enriching and nourishing blood, and promoting blood circulation and removing blood stasis, and able to nourish Yin and tonify kidney, enrich blood and promote blood circulation, and cure or prevent patients with kidney and blood deficiency, sub-healthy persons, the middle-aged and aged and paitents with diabetes from many related diseases caused by anaemia and blood stasis. And the invention is a 'Dihuang preparation with four tonifying functions and four removing functions'.
Owner:吴开敏

Preparation method and application of Liuwei Dihuang pills

The invention belongs to the field of traditional Chinese medicine preparations and particularly relates to a preparation method of Liuwei Dihuang pills. The Liuwei Dihuang pills are made from 120g of prepared rehmannia root, 60g of common Macrocarpium fruit, 45g of root-bark of tree peony, 60g of common yam rhizome, 45g of Indian bread and 45g of rhizome of oriental water plantain. The Liuwei Dihuang pills are prepared with macroporous resin, cation exchange resin and anion exchange resin, so that contents are greatly increased and less usage is required. The invention further provides application of the Liuwei Dihuang pills in the preparation of medicaments for inhibiting proliferation of mouse embryonic fibroblast NIH3T3.
Owner:NANJING TONGRENTANG PHARM CO LTD

Preparation method of pepsin and trypsin treated Liuwei Dihuang composite micro-ecological oral liquid

The invention relates to a preparation method of pepsin and trypsin treated Liuwei Dihuang composite micro-ecological oral liquid. The preparation method comprises the following steps: (1) crushing Liuwei Dihuang pill raw materials, adding water, and mixing uniformly to prepare raw material serous fluid; (2) adding acid into the raw material serous fluid to adjust the pH value, and adding pepsin for treatment, thereby preparing pepsin treated serous fluid; (3) adding trypsin into the pepsin treated serous fluid for treatment to prepare the pepsin and trypsin treated serous fluid; and (4) inoculating bifidobacteria and lactobacillus plantarum to obtain the pepsin treated Liuwei Dihuang composite micro-ecological oral liquid. The pepsin and trypsin treated Liuwei Dihuang composite micro-ecological oral liquid prepared by the preparation method provided by the invention is relatively small in side effect, and is palatable in sweet and sour tastes; and by virtue of practical application, after being taken for a long time, the pepsin and trypsin treated Liuwei Dihuang composite micro-ecological oral liquid not only can achieve a treatment effect of Liuwei Dihuang pills but also greatly reduces the side effects causing stomach cold and digestion obstruction.
Owner:白杨

Large specification Liuweidihang dripping pills contg. glutinous rehmannia and five other herb medicines, and its prepn. method

A large-dosage dripping pill of six drugs including rehmannia is prepared from 6 Chinese-medicinal materials including prepared rehmannia root, dogwood fruit, tree peony bark, yam, tuckahoe and alismatis rhizome. Its preparing process is also disclosed.
Owner:JIANGXI JIMINKEXIN PHARMA

HPLC-DAD based six-ingredient rehmannia pill prescription analysis and quality analysis method

The invention relates to a quality control method of a traditional Chinese medicine compound preparation, in particular to a prescription analysis and quality analysis method of six-ingredient rehmannia pill based on a high performance liquid chromatography-diode array detection technology (HPLC-DAD). The method comprises the following two parts: firstly, respectively identifying the characteristic peaks of six prescription decoction pieces in a plurality of wavelength modes by utilizing the difference of ultraviolet absorption spectra of chemical components of the six decoction pieces in the six-ingredient rehmannia pill, and establishing a six-ingredient rehmannia pill prescription analysis method based on the characteristic peaks of the decoction pieces; and secondly, developing a quality marker (Q-Marker) of the six-ingredient decoction pieces on the basis of the characteristic peaks of the decoction pieces, and analyzing the current quality situation of the six decoction pieces in the six-ingredient rehmannia pill by using the Q-Marker. The prescription analysis and quality analysis method provided by the invention is simple and efficient, and lays a scientific foundation for the overall quality control of the six-ingredient rehmannia pill.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

New six-ingredient rehmannia pill

Six-ingredient rehmannia pill is a famous ancient medicine which is applied for almost a thousand years, and is also a popular drug which is often taken by people for a long term in pursuit of health care and body building, however, alisma in the raw material medicine can cause gastroenteritis, nausea, vomiting, dizziness, eye faint, abdominal pain, diarrhea, limb weakness, loss of appetite, itching, angioedema, allergic skin rashes or even respiratory paralysis and other poisoning symptoms. The ancient and modern medical literature points out that the alisma can not be taken for a long term or with a large amount at early time, or else, the long-term taking of the alisma can also cause sever side effects such as kidney toxicity and thus resulting in acute tubular necrosis and the like. The traditional Chinese medicine phellodendron has the function of reducing renal fire of the alisma in the six-ingredient rehmannia pill. The six-ingredient rehmannia pill is used to replace the alisma, is improved into a new six-ingredient rehmannia pill, not only can maintain the functions of nourishing yin and tonifying the kidney of the ancient six-ingredient rehmannia pill, but also can avoid adverse reactions caused by the use of the alisma, thereby being conducive to improving the safety of the medicine and being capable of obtaining a considerable amount of market share in the competition with the original six-ingredient rehmannia pill.
Owner:吴开敏

Preparation method of Liuwei Dihuang pills

The invention discloses a preparation method of Liuwei Dihuang pills. The Liuwei Dihuang pills comprise the following medicinal effective components in parts by weight: 160 parts of prepared radix rehmanniae, 80 parts of wine-prepared fructus corni, 60 parts of moutan bark, 80 parts of Chinese yam, 60 parts of poria cocos and 60 parts of rhizoma alismatis. The preparation method of the pills comprises the following steps: (1) preparing medicinal powder: taking the prepared radix rehmanniae, the fructus corni, the moutan bark, the Chinese yam, the poria cocos and the rhizoma alismatis, crushing, sieving and uniformly mixing to obtain the medicinal powder; (2) preparing an adhesive: taking glycerol into a container, adding medicinal carboxymethyl cellulose salt, uniformly stirring, sealing, and heating until the carboxymethyl cellulose salt is completely swelled, so as to prepare the adhesive for later use; and (3) preparing the pills: adding the adhesive accounting for 25-50% of the total amount of the prepared medicine into a paste powder mixture, uniformly mixing, and pelleting to obtain the Liuwei Dihuang pills. According to the invention, the prepared Liuwei Dihuang pills have the beneficial effects that ethanol, refined honey and water are not used as adhesives, the prepared Liuwei Dihuang pills do not need to be subjected to a drying process, the volatile component paeonol in the finished product is low in loss, the content is relatively high, the dispersion time limit is short, and the quality is stable and controllable.
Owner:贵州汉方药业有限公司 +1

The preparation method of Liuwei Dihuang Wan

The invention discloses a preparation method of Liuweidihuang pills. The preparation method adopts a diaphragm press filtration cycle extraction separation integrated technology to extract active ingredients of prescription drugs. The preparation method simplifies a process flow, shortens greatly a production period, saves energy consumption, is beneficial for environmental protection and dreg utilization, and improves greatly an active ingredient recovery rate.
Owner:TAIJI GRP CHONGQING FULING PHARM FACTORY CO LTD

Flour containing traditional Chinese medicine health-care components and preparation method of flour

The invention relates to flour containing traditional Chinese medicine health-care components and a preparation method of the flour. The flour is characterized by being prepared from the following rawmaterials in parts by weight: 300-350 parts of flour, 30-50 parts of corn flour, 10-12 parts of radix rehmanniae, 3-5 parts of poria cocos, 2-3 parts of rhizoma alismatis, 3-5 parts of asiatic cornelian cherry fruits, 6-9 parts of Chinese yams, 2-3 parts of cortex moutan, 1-2 parts of chrysanthemums, 10-12 parts of Chinese wolfberry fruits, 3-5 parts of green tea, 2-3 parts of Chinese chestnut leaves, 2-3 parts of prunus humilis bunge leaves, and 2-3 parts of pseudostellaria maximowicziana. The raw materials contain components of a traditional Chinese medicine namely pills of six drugs with rehmannia, and besides, the chrysanthemums, the Chinese wolfberry fruits, the green tea and the like are added, so that the formula has the effects of nourishing kidney yin, clearing and reducing deficient fire and improving immunity, has a certain function of removing toxicity, can prevent mutation, can be eaten for a long term, and is beneficial for human health.
Owner:郑州助协生物科技有限公司

Traditional Chinese medicine composition for treating blepharospasm

The invention provides a traditional Chinese medicine composition used for treating blepharospasm. The traditional Chinese medicine composition is obtained through improvement based on main ingredients of Liuwei Dihuang pills and comprises rehmannia root, common macrocarpium fruit, rhizoma dioscoreae, oriental waterplantain rhizome, tree peony bark, Indian buead, tall gastrodia tuber, spina date seed, tuber fleeceflower stem, rhizome of drug sweetflag, chrysanthemum, barbary wolfberry fruit, radix astragali, Chinese angelica, antelope horn powder, gambir plant and red paeony root. The medicine has the functions of nourishing kidney yin, protecting nerves and replenishing vital essence to improve eyesight, is short in medication time, is convenient to use and has high cure rate and low recurrence rate.
Owner:FIRST HOSPITAL AFFILIATED TO GENERAL HOSPITAL OF PLA

Nano microcapsule for six ingredients with rehmannia and preparation process thereof

The invention discloses a nano microcapsule for six ingredients with rehmannia and a preparation process thereof. The preparation process comprises the following steps of: taking the traditional pills for six ingredients with the rehmannia as a basis, adopting a multilevel dynamic hot reflux method for extraction and concentration of radix rehmanniae preparata, Poria cocos and rhizoma alismatis; carrying out nano-level crushing on dogwood, tree peony bark and yam; and uniformly mixing the nano fine powder and concentrated liquor according to certain proportion, carrying out freezing or spray-drying treatment, preparing the nano microcapsule, and finally adopting a corresponding preparation technology to prepare into a dosage form applicable on clinic. The process has the advantages of simple operation, short process flow, easy control of parameters, low cost, no toxic and side effects caused by organic reagents and the like. The nano microcapsule for six ingredients with the rehmannia can be directly used, and also can be used as a drug intermediate. In the nano microcapsule, the drug effect can be obviously delayed, the administration times and amount can be reduced, and the toxic and side effect caused by the traditional drug is reduced or eliminated. The nano microcapsule is concentrated by more than three times compared with the existing nano microcapsule product for six ingredients with the rehmannia on the market, and the total daily dosage can be reduced by 3-6 times compared with the traditional products such as the concentrated six ingredients with the rehmannia and the like.
Owner:HENAN UNIVERSITY OF TECHNOLOGY +1

A Liuweidihuang nano-microcapsule and its preparation process

The invention discloses a nano microcapsule for six ingredients with rehmannia and a preparation process thereof. The preparation process comprises the following steps of: taking the traditional pills for six ingredients with the rehmannia as a basis, adopting a multilevel dynamic hot reflux method for extraction and concentration of radix rehmanniae preparata, Poria cocos and rhizoma alismatis; carrying out nano-level crushing on dogwood, tree peony bark and yam; and uniformly mixing the nano fine powder and concentrated liquor according to certain proportion, carrying out freezing or spray-drying treatment, preparing the nano microcapsule, and finally adopting a corresponding preparation technology to prepare into a dosage form applicable on clinic. The process has the advantages of simple operation, short process flow, easy control of parameters, low cost, no toxic and side effects caused by organic reagents and the like. The nano microcapsule for six ingredients with the rehmannia can be directly used, and also can be used as a drug intermediate. In the nano microcapsule, the drug effect can be obviously delayed, the administration times and amount can be reduced, and the toxic and side effect caused by the traditional drug is reduced or eliminated. The nano microcapsule is concentrated by more than three times compared with the existing nano microcapsule product for six ingredients with the rehmannia on the market, and the total daily dosage can be reduced by 3-6 times compared with the traditional products such as the concentrated six ingredients with the rehmannia and the like.
Owner:HENAN UNIVERSITY OF TECHNOLOGY +1

Detection system and detection method for concentration process of Liuwei Dihuang pills

PendingCN112924411AJudgment of real-time quality complianceMaterial analysis by optical meansLiu Wei Di HuangFlow cell
The invention discloses a detection system and a detection method for the concentration process of Liuwei Dihuang pills. The detection system comprises a control terminal, a near-infrared spectrometer, a detection pipeline, and a first valve body, a filtering device, a pump body, a flow cell and a second valve body which are sequentially arranged along the detection pipeline; the two ends of the detection pipeline are communicated with the concentrator, so that a part of liquid medicine flowing in the concentrator is shunted to the detection pipeline; the filtering device is used for filtering the liquid medicine flowing through the detection pipeline; the pump body is used for supplying liquid medicine in the concentrator to the flow cell; and a machine body of the near-infrared spectrometer is in communication connection with the control terminal, and a probe of the near-infrared spectrometer is arranged in the flow cell to obtain an infrared spectrogram of the liquid medicine in the flow cell and transmit the infrared spectrogram to the control terminal. The invention aims to solve the technical problem of lack of quality control in the concentration process of the Liuwei Dihuang pills in the prior art.
Owner:JIUZHITANG

Preparation method of pepsin and trypsin treated Liuwei Dihuang oral liquid

The invention relates to a preparation method of pepsin and trypsin treated Liuwei Dihuang oral liquid. The preparation method comprises the following steps: (1) crushing Liuwei Dihuang pill raw materials to prepare raw material powder, adding water, and mixing uniformly to prepare raw material serous fluid; (2) adding acid into the raw material serous fluid to adjust the pH value, and adding pepsin for treatment, and adjusting the pH value by using alkali, thereby preparing pepsin treated serous fluid; and (3) adding trypsin into the pepsin treated serous fluid for treatment, and adjusting the pH value to prepare the pepsin and trypsin treated Liuwei Dihuang oral liquid. The pepsin and trypsin treated Liuwei Dihuang oral liquid is prepared by the preparation method provided by the invention by decomposing the traditional Liuwei Dihuang pill raw materials by virtue of pepsin and trypsin, is relatively small in side effect, and is palatable in sweet and sour tastes; and by virtue of practical application, after being taken for a long time, the pepsin and trypsin treated Liuwei Dihuang oral liquid not only can achieve a treatment effect of Liuwei Dihuang pills but also can greatly reduce the side effects causing stomach cold and digestion obstruction.
Owner:白杨

Compound traditional Chinese medicine active constitutes capable of improving erythrocyte deformability and preparation method thereof

The invention discloses a compound Chinese medicament effective composition for improving the deformability of erythrocytes and a preparation method thereof. The compound Chinese medicament effective composition is an effective composition which is extracted from prepared rehmannia rhizome, dogwood, tree peony bark, Chinese yam, poria and Alisma orientale by an alcohol extraction method on the basis of a Chinese medicine compound recipe of Liuwei tonic pills. Preliminary experiments prove that the effective composition can improve the deformability of the erythrocytes. The effective composition is applied to medicaments or health-care products for improving the deformability of the erythrocytes. The preparation method has simple process and low cost, is easy to obtain the effective composition, is suitable for industrialized production, and can be used for preparing the medicaments and the health-care products for treating the deformability of the erythrocytes of sub-health population.
Owner:TROPICAL CORP STRAIN RESOURCE INST CHINESE ACAD OF TROPICAL AGRI SCI
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