34 results about "Liu-wei-di-huang wan" patented technology

The invention relates to an on-line detection method of near infrared spectrum for production process of traditional Chinese medicine, pill of six ingredients with rehmannia. The on-line detection method comprises the following steps: (1) selection of a calibration set sample; (2) property determination of the calibration set sample; (3) near infrared absorption spectrometry determination of the calibration set sample; (4) establishment of a calibration model; and (5) property determination of an unknown sample, namely leading a near infrared absorption spectrum value of the unknown sample into the calibration model established in the step (4) and then obtaining the content of target ingredients in the unknown sample after model calculation. The on-line detection method has the advantagesof simpleness, correction and good ruggedness, application for on-line quality control of the pill of six ingredients with rehmannia, and capability of resolving the problems of long time consumption,low efficiency and the like of the traditional off-line detection in production process.

The present invention provides a concentrated Liuwei dihuang pill preparation method. According to the method, the existing preparation method is improved so as to effectively improve component transfer rate and paste yield, save energy consumption and reduce active ingredient loss.

The invention provides Maca compositions, and a compound preparation and an application thereof. The invention provides the Maca zinc composition with a Maca powder and nutrition zinc as active ingredients. The invention provides the Maca-Liuweidihuang pill composition with a Maca powder and a Liuweidihuang pill extract as active ingredients. The invention provides the Maca-wolfberry-radix astragali composition with a Maca powder, radix astragali, wolfberry and soybean isoflavone as active ingredients. The invention provides the Maca-radix puerariae composition with a Maca powder, radix puerariae and raspberry as active ingredients. The series of compositions added with edible auxiliary materials can be made into tablets (pressed cadies) and capsules. The compositions are in matched combination according to respective functional characteristics, and have a series of functions of tonifying kidney, tonifying yang, relieving physical fatigue, treating prostatitis, treating climacteric syndromes and resisting depression.

The invention relates to a quantitative determination method of pills of six ingredients with rehmannia, and a preparation method and application thereof. The adopted technical scheme is as follows: each millilitre of the contrast Chinese patent medicine extract of the pills of six ingredients with rehmannia contains 16.71-66.82 mu g of 5-hydroxymethylfurfural, 30.56-122.22 mu g of mrroniside, 19.52-78.06 mu g of loganin, 12.71-50.84 mu g of paeoniflorin, and 40.27-161.06 mu g of paeonol. The content determination of the pills of six ingredients with rehmannia is carried out by taking the contrast Chinese patent medicine extract of the pills of six ingredients with rehmannia provided by the invention as the standard substance and adopting a high-erformance liquid chromatography; therefore, the method is capable of simultaneously controlling a plurality of components, simplifying a checkout process and greatly reducing checkout cost and meets with the technology development tendency in the traditional Chinese checkout field; furthermore, the preparation method of the contrast extract is simple and convenient and is beneficial to being popularized and applied and has strong practicability.

The invention relates to a method for producing a feed by using herb residues of liu-wei-di-huang pills through fermentation. A fermentation raw material mainly adopts the waste herb residues produced by extracting medicinal components from raw medicinal material liu-wei-di-huang pills and is subjected to solid fermentation culture by inoculating aspergillus niger, so that a plant fermented protein feed containing mycoproteins is obtained. The production technology disclosed by the invention is simple, and the cost is low; a produced product is safe and non-toxic; furthermore, after fermentation, the content of the proteins in the herb residues of the liu-wei-di-huang pills is effectively increased; the effects of the herb residues of liu-wei-di-huang pills is fully used; therefore, the feed has the health-protection effects of enhancing the immunity of animals, adjusting metabolism, promoting growth and improving the meat quality of the animals.

Liuwei Dihuang Pill is a Chinese medicinal preparation based on ancient prescription, but alisol, one of its ingredients has the side effect of causing nausea, emesis, dizziness, abdominalgia, myasthenia of limbs and other diseases. By substituting alisol with bark of boxthron-root, the invention provides another Liuwei Dihuang preparation for sustaining the action of body fluid reinforcing and kidney tonifying, and preventing adverse effects of alisol.

Ancient prescription liu-wei tonic pills frequently cause a plurality of untoward effects due to alisma orientale in compositions; and the dosage is large, and the treatment effect can only be achieved by taking 8 granules at a time, which can not meet the requirement of the China Pharmacopoeia Committee that 'only 2 granules are required for taking'. The invention relates to novel liu-wei tonic preparation, which is a novel medicine prepared by replacing the alisma orientale in preparation such as the liu-wei tonic pills and so on into cortex lycii radicis. The novel liu-wei tonic preparation adopts the CO2 supercutical fluid extraction method and utilizes manufacturing techniques such as the technology for gradient filtration and separation through an ultrafiltration membrane, improves the yield, avoids damage of high temperature on effective ingredients, has high bioavailability, and also can remove a plurality of impurities and ineffectual ingredients and greatly reduce the dosage. Because the novel liu-wei tonic preparation produced by any method can prepare various preparation types which are the same as the prior liu-wei tonic preparation, the homonymy phenomena of the novel medicine and the prior medicine can occur certainly, 'novel' is named before the prior name as for improved novel products, i.e. named as novel liu-wei tonic pills, novel liu-wei tonic tablets, novel liu-wei tonic capsules and so on.

The invention relates to a preparation method of pepsin and trypsin treated Liuwei Dihuang composite micro-ecological oral liquid. The preparation method comprises the following steps: (1) crushing Liuwei Dihuang pill raw materials, adding water, and mixing uniformly to prepare raw material serous fluid; (2) adding acid into the raw material serous fluid to adjust the pH value, and adding pepsin for treatment, thereby preparing pepsin treated serous fluid; (3) adding trypsin into the pepsin treated serous fluid for treatment to prepare the pepsin and trypsin treated serous fluid; and (4) inoculating bifidobacteria and lactobacillus plantarum to obtain the pepsin treated Liuwei Dihuang composite micro-ecological oral liquid. The pepsin and trypsin treated Liuwei Dihuang composite micro-ecological oral liquid prepared by the preparation method provided by the invention is relatively small in side effect, and is palatable in sweet and sour tastes; and by virtue of practical application, after being taken for a long time, the pepsin and trypsin treated Liuwei Dihuang composite micro-ecological oral liquid not only can achieve a treatment effect of Liuwei Dihuang pills but also greatly reduces the side effects causing stomach cold and digestion obstruction.

The invention discloses a preparation method of Liuwei Dihuang pills. The Liuwei Dihuang pills comprise the following medicinal effective components in parts by weight: 160 parts of prepared radix rehmanniae, 80 parts of wine-prepared fructus corni, 60 parts of moutan bark, 80 parts of Chinese yam, 60 parts of poria cocos and 60 parts of rhizoma alismatis. The preparation method of the pills comprises the following steps: (1) preparing medicinal powder: taking the prepared radix rehmanniae, the fructus corni, the moutan bark, the Chinese yam, the poria cocos and the rhizoma alismatis, crushing, sieving and uniformly mixing to obtain the medicinal powder; (2) preparing an adhesive: taking glycerol into a container, adding medicinal carboxymethyl cellulose salt, uniformly stirring, sealing, and heating until the carboxymethyl cellulose salt is completely swelled, so as to prepare the adhesive for later use; and (3) preparing the pills: adding the adhesive accounting for 25-50% of the total amount of the prepared medicine into a paste powder mixture, uniformly mixing, and pelleting to obtain the Liuwei Dihuang pills. According to the invention, the prepared Liuwei Dihuang pills have the beneficial effects that ethanol, refined honey and water are not used as adhesives, the prepared Liuwei Dihuang pills do not need to be subjected to a drying process, the volatile component paeonol in the finished product is low in loss, the content is relatively high, the dispersion time limit is short, and the quality is stable and controllable.

The invention discloses a preparation method of Liuweidihuang pills. The preparation method adopts a diaphragm press filtration cycle extraction separation integrated technology to extract active ingredients of prescription drugs. The preparation method simplifies a process flow, shortens greatly a production period, saves energy consumption, is beneficial for environmental protection and dreg utilization, and improves greatly an active ingredient recovery rate.

The invention discloses a nano microcapsule for six ingredients with rehmannia and a preparation process thereof. The preparation process comprises the following steps of: taking the traditional pills for six ingredients with the rehmannia as a basis, adopting a multilevel dynamic hot reflux method for extraction and concentration of radix rehmanniae preparata, Poria cocos and rhizoma alismatis; carrying out nano-level crushing on dogwood, tree peony bark and yam; and uniformly mixing the nano fine powder and concentrated liquor according to certain proportion, carrying out freezing or spray-drying treatment, preparing the nano microcapsule, and finally adopting a corresponding preparation technology to prepare into a dosage form applicable on clinic. The process has the advantages of simple operation, short process flow, easy control of parameters, low cost, no toxic and side effects caused by organic reagents and the like. The nano microcapsule for six ingredients with the rehmannia can be directly used, and also can be used as a drug intermediate. In the nano microcapsule, the drug effect can be obviously delayed, the administration times and amount can be reduced, and the toxic and side effect caused by the traditional drug is reduced or eliminated. The nano microcapsule is concentrated by more than three times compared with the existing nano microcapsule product for six ingredients with the rehmannia on the market, and the total daily dosage can be reduced by 3-6 times compared with the traditional products such as the concentrated six ingredients with the rehmannia and the like.

The invention discloses a detection system and a detection method for the concentration process of Liuwei Dihuang pills. The detection system comprises a control terminal, a near-infrared spectrometer, a detection pipeline, and a first valve body, a filtering device, a pump body, a flow cell and a second valve body which are sequentially arranged along the detection pipeline; the two ends of the detection pipeline are communicated with the concentrator, so that a part of liquid medicine flowing in the concentrator is shunted to the detection pipeline; the filtering device is used for filtering the liquid medicine flowing through the detection pipeline; the pump body is used for supplying liquid medicine in the concentrator to the flow cell; and a machine body of the near-infrared spectrometer is in communication connection with the control terminal, and a probe of the near-infrared spectrometer is arranged in the flow cell to obtain an infrared spectrogram of the liquid medicine in the flow cell and transmit the infrared spectrogram to the control terminal. The invention aims to solve the technical problem of lack of quality control in the concentration process of the Liuwei Dihuang pills in the prior art.

The invention relates to a preparation method of pepsin and trypsin treated Liuwei Dihuang oral liquid. The preparation method comprises the following steps: (1) crushing Liuwei Dihuang pill raw materials to prepare raw material powder, adding water, and mixing uniformly to prepare raw material serous fluid; (2) adding acid into the raw material serous fluid to adjust the pH value, and adding pepsin for treatment, and adjusting the pH value by using alkali, thereby preparing pepsin treated serous fluid; and (3) adding trypsin into the pepsin treated serous fluid for treatment, and adjusting the pH value to prepare the pepsin and trypsin treated Liuwei Dihuang oral liquid. The pepsin and trypsin treated Liuwei Dihuang oral liquid is prepared by the preparation method provided by the invention by decomposing the traditional Liuwei Dihuang pill raw materials by virtue of pepsin and trypsin, is relatively small in side effect, and is palatable in sweet and sour tastes; and by virtue of practical application, after being taken for a long time, the pepsin and trypsin treated Liuwei Dihuang oral liquid not only can achieve a treatment effect of Liuwei Dihuang pills but also can greatly reduce the side effects causing stomach cold and digestion obstruction.

The invention discloses a compound Chinese medicament effective composition for improving the deformability of erythrocytes and a preparation method thereof. The compound Chinese medicament effective composition is an effective composition which is extracted from prepared rehmannia rhizome, dogwood, tree peony bark, Chinese yam, poria and Alisma orientale by an alcohol extraction method on the basis of a Chinese medicine compound recipe of Liuwei tonic pills. Preliminary experiments prove that the effective composition can improve the deformability of the erythrocytes. The effective composition is applied to medicaments or health-care products for improving the deformability of the erythrocytes. The preparation method has simple process and low cost, is easy to obtain the effective composition, is suitable for industrialized production, and can be used for preparing the medicaments and the health-care products for treating the deformability of the erythrocytes of sub-health population.