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Compound traditional Chinese medicine active constitutes capable of improving erythrocyte deformability and preparation method thereof

A technology of effective parts and compound traditional Chinese medicine, applied in the field of medicine, can solve the problems of specific material basis, unclear active ingredients or active parts, chemical ingredients, and insufficient research on pharmacodynamics, etc., and achieve the effect of low cost and simple process

Inactive Publication Date: 2011-08-17
TROPICAL CORP STRAIN RESOURCE INST CHINESE ACAD OF TROPICAL AGRI SCI
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Although a lot of progress has been made in the research on the preparation and quality control of Liuwei Dihuang Pills in recent years, the research on other aspects of this prescription, such as chemical components and pharmacodynamics, is not deep enough. For example, the various pharmacological effects of this prescription The specific material basis, active ingredient or active site is still unclear
Furthermore, the pharmacodynamic studies on Liuwei Dihuang Pills are mainly focused on enhancing immune function, anti-aging, anti-tumor and anti-toxic side effects of chemotherapy drugs, lowering blood sugar, mediating blood lipids, lowering blood pressure, etc. [Zhou Jingyan, Han Lixin. Liuwei Dihuang Pills The modern research and progress of [J]. Chinese Pharmacist, 2008, 11(6): 710], but its effect on red blood cell deformability and its active site have not been reported in the literature

Method used

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  • Compound traditional Chinese medicine active constitutes capable of improving erythrocyte deformability and preparation method thereof
  • Compound traditional Chinese medicine active constitutes capable of improving erythrocyte deformability and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0016] 1. Preparation of effective parts

[0017] Take Rehmannia glutinosa 320g, Cornus officinalis 160g, Moutan cortex 120g, Chinese yam 160g, Poria cocos 120g, Alisma 120g, a total of 1kg to form a compound medicinal material, pulverized (40 mesh), put into an ultrasonic extraction tank, soaked in 85% ethanol for 30min to desorb, The ratio of solid to liquid is 1:2. Add 6 times the volume of 80°C distilled water, ultrasonically extract twice, each time for 2 minutes, and filter, with ultrasonic power of 100W. The two extracts were combined, ethanol was recovered under reduced pressure, concentrated to 500ml, and the pH value was adjusted to 3. The concentrated solution is subjected to multi-stage countercurrent extraction with ethyl acetate which has been pretreated as the extractant. Add 250ml of the concentrated solution and ethyl acetate as the extraction agent into the separatory funnel, shake well, extract for 5 minutes and then separate the phases. The ethyl acetate...

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Abstract

The invention discloses a compound Chinese medicament effective composition for improving the deformability of erythrocytes and a preparation method thereof. The compound Chinese medicament effective composition is an effective composition which is extracted from prepared rehmannia rhizome, dogwood, tree peony bark, Chinese yam, poria and Alisma orientale by an alcohol extraction method on the basis of a Chinese medicine compound recipe of Liuwei tonic pills. Preliminary experiments prove that the effective composition can improve the deformability of the erythrocytes. The effective composition is applied to medicaments or health-care products for improving the deformability of the erythrocytes. The preparation method has simple process and low cost, is easy to obtain the effective composition, is suitable for industrialized production, and can be used for preparing the medicaments and the health-care products for treating the deformability of the erythrocytes of sub-health population.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to an effective part of a compound traditional Chinese medicine based on a traditional Chinese medicine compound of Liuwei Dihuang Pills and a preparation method thereof. The effective part can be applied to the preparation of medicines or health care products for treating changes in red blood cell morphology of sub-healthy people. Background technique [0002] Since Qian Yi created Liuwei Dihuang Pills, physicians of all dynasties have highly praised this prescription and widely used it clinically. This prescription is recorded in the 2005 edition of the Pharmacopoeia of the People's Republic of China, and its composition is 160g of Rehmannia glutinosa, 80g of Cornus officinalis (burnt), 60g of Moutan cortex, 80g of Chinese yam, 60g of Poria, and 60g of Alisma. The efficacy of this prescription is to nourish yin and invigorate the kidney, and it is used for deficiency o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P7/00
Inventor 董志超金宏波张永春
Owner TROPICAL CORP STRAIN RESOURCE INST CHINESE ACAD OF TROPICAL AGRI SCI
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