Preparation method of pepsin and trypsin treated Liuwei Dihuang oral liquid
A technology of Rehmannia glutinosa oral liquid and trypsin is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, drug delivery, etc., to achieve the effect of reducing side effects
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Embodiment 1
[0025] A preparation method of Liuwei Dihuang oral liquid treated with stomach and trypsin, the steps are as follows:
[0026] (1) After pulverizing the Liuwei raw material medicine in Liuwei Dihuang Wan raw materials, the raw material powder is obtained, and then 200 grams of water and refined honey are added for every 100 grams of raw material powder, and the raw material slurry is obtained by mixing evenly;
[0027] (2) Add hydrochloric acid to the raw material slurry prepared in step (1) to adjust the pH value to 1.5, add 20 activity units of pepsin per 100 grams of Liuwei Dihuang Wan raw material, treat at 36°C for 3 hours, adjust with sodium carbonate The pH value is 8, and the pepsin-treated slurry is obtained;
[0028] (3) Add 50 activity units of trypsin per 100 ml to the pepsin-treated slurry prepared in step (2), treat at a temperature of 37° C. for 2 hours, and adjust the pH value to 5.5 with hydrochloric acid to obtain stomach, Liuwei Dihuang oral liquid treated ...
Embodiment 2
[0032] A preparation method of Liuwei Dihuang oral liquid treated with stomach and trypsin, the steps are as follows:
[0033] (1) After pulverizing the Liuwei raw material drug in the Liuwei Dihuang Wan raw material, the raw material powder is obtained, and then 600 grams of water and refined honey are added for every 100 grams of the raw material powder, and the raw material slurry is obtained by mixing evenly;
[0034] (2) Add acid to the raw material slurry prepared in step (1) to adjust the pH value to 2.2, add 60 activity units of pepsin per 100 grams of Liuwei Dihuang Wan raw material, and treat it for 2 hours at a temperature of 38 ° C, and adjust it with sodium carbonate. The pH value is 7.8, and the pepsin-treated slurry is obtained;
[0035] (3) Add 20 activity units of trypsin per 100 ml to the pepsin-treated slurry prepared in step (2), treat at a temperature of 37° C. for 3 hours, and adjust the pH value to 6 with hydrochloric acid to obtain stomach, Liuwei Dihu...
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