Preparation method of Liuwei Dihuang pills

Abstract

The invention discloses a preparation method of Liuwei Dihuang pills. The Liuwei Dihuang pills comprise the following medicinal effective components in parts by weight: 160 parts of prepared radix rehmanniae, 80 parts of wine-prepared fructus corni, 60 parts of moutan bark, 80 parts of Chinese yam, 60 parts of poria cocos and 60 parts of rhizoma alismatis. The preparation method of the pills comprises the following steps: (1) preparing medicinal powder: taking the prepared radix rehmanniae, the fructus corni, the moutan bark, the Chinese yam, the poria cocos and the rhizoma alismatis, crushing, sieving and uniformly mixing to obtain the medicinal powder; (2) preparing an adhesive: taking glycerol into a container, adding medicinal carboxymethyl cellulose salt, uniformly stirring, sealing, and heating until the carboxymethyl cellulose salt is completely swelled, so as to prepare the adhesive for later use; and (3) preparing the pills: adding the adhesive accounting for 25-50% of the total amount of the prepared medicine into a paste powder mixture, uniformly mixing, and pelleting to obtain the Liuwei Dihuang pills. According to the invention, the prepared Liuwei Dihuang pills have the beneficial effects that ethanol, refined honey and water are not used as adhesives, the prepared Liuwei Dihuang pills do not need to be subjected to a drying process, the volatile component paeonol in the finished product is low in loss, the content is relatively high, the dispersion time limit is short, and the quality is stable and controllable.

Description

technical field [0001] The invention relates to Liuwei Dihuang Wan, in particular to a preparation method of Liuwei Dihuang Wan (flexible pill). Background technique [0002] The drug standard WS3-B-2102-96 of the Ministry of Health records: Liuwei Dihuang Pills (concentrated pills) have the effect of nourishing yin and nourishing the kidney, and are used for kidney yin deficiency, dizziness and tinnitus, sore waist and knees, bone steaming hot flashes, night sweats, nocturnal emission, and thirst . The legal prescription and preparation method of Liuwei Dihuang Pills (Shuimi Pills, Xiaomi Pills, Honey Pills) are recorded in the "Chinese Pharmacopoeia" 2020 Edition, the prescription: rehmannia glutinosa 160g; wine cornus 80g; moutan cortex 60g; yam 80g; Poria cocos 60g; Alisma 60g; preparation method: grind the above six flavors into fine powder, sieve, and mix well. Use ethanol to make pills, dry them to make water pills, or add 35-50g of refined honey and appropriate amo...

AI Technical Summary

Problems solved by technology

[0003] Liuwei Dihuang Pills (water pills) mainly use ethanol as the binder for pan pills, and Liuwei Dihuang Pills (water honey pills, honey pills) mainly use refined honey as the binder for pan pills. Since the above two excipients will contain a certain amount of water, during the preparation process, Usually, the pills should be dried after panning. The drying temperature (60-80°C) and the drying time are about 6-24 hours. Paeonol is very easy to volatilize at about 50°C, causing a large amount of volatile components to volatilize and lose, resulting in a decrease in the content of the finished product. Even if the content of paeonol in the finished product is controlled within the acceptable range by various methods, after a period of time , the paeonol on the surface of the pills will also volatilize slowly, which not only makes pores appear on the surface of the pills, but more importantly reduces the content of paeonol and affects the quality of the medicine

A continuous and automated production line that integrates multiple advantageous technologies such as cleaning, drying, vacuum pipeline transportation, low-temperature crushing, and automatic mixing into the raw material pretreatment process can also increase the content of paeonol, but the cost of establishing such a production line is relatively high. high

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