On-line detection method of near infrared spectrum for production process of traditional Chinese medicine, pill of six ingredients with rehmannia

A technology of Liuwei Dihuang Pills and near-infrared spectroscopy, which is applied in the field of quality inspection in the production process of traditional Chinese medicine, can solve the problems of cumbersome process, high labor intensity, unfavorable continuous production, etc., and achieve the effect of good reproducibility and simple detection method

Inactive Publication Date: 2010-03-10
EAST CHINA UNIV OF SCI & TECH
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  • Abstract
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Problems solved by technology

However, the feedback of the analysis results lags behind, and the quality control can only be carried out offline. The process is cumbersome, labor-intensive, and there are human uncertain factors, which is not conducive to continuous production.

Method used

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  • On-line detection method of near infrared spectrum for production process of traditional Chinese medicine, pill of six ingredients with rehmannia
  • On-line detection method of near infrared spectrum for production process of traditional Chinese medicine, pill of six ingredients with rehmannia
  • On-line detection method of near infrared spectrum for production process of traditional Chinese medicine, pill of six ingredients with rehmannia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] An alcohol extraction process of Liuwei Dihuang Pills is detected on-line, and its specific steps are:

[0034] (1) Add 10 times the amount of 1L 95% ethanol to 100g of Moutan cortex decoction pieces, the extraction temperature is 85°C, the extraction time is 2h, extraction is performed twice, sampling is done every 10min, and 3 batches of the above samples are prepared for modeling;

[0035] (2) Determining the content of paeonol and paeoniflorin in the above-mentioned technological process sample with high performance liquid chromatography, and use this content value as a calibration set sample during modeling;

[0036] The high performance liquid chromatography condition that adopts in the above-mentioned step (2) is: mobile phase 0.5% formic acid (A)-acetonitrile (B), phase B gradient is, 0~8min 90~85%, 8~20min 85~80% , 20-25min 80-40%, 25-30min 40-15%; column temperature 25°C, flow rate 1ml / min, detection wavelength 250nm, running time 35min, injection volume 10μl;...

Embodiment 2

[0044] An extraction process of water-soluble components of Liuwei Dihuang Pills is carried out on-line detection, and the specific steps are as follows:

[0045] (1) Mix 23g of Cornus officinalis, 267g of Rehmannia glutinosa, 100g of Poria cocos, 100g of Alisma chinensis and the dregs of moutan cortex in Example 1, add 10 times the amount of water, decoct and extract for 1.5h, and take samples every 10min to prepare 3 batches of the above samples for modeling purposes;

[0046] (2) Determination of the content of loganin and gallic acid in the above-mentioned technological process sample with high performance liquid chromatography, take this content value as the calibration set sample when modeling;

[0047] The high performance liquid chromatography condition is the same as method in embodiment 1, and the high performance liquid chromatography of water extraction process terminal sample is as follows Figure 4 As shown, the extraction curves of loganin and gallic acid over ...

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Abstract

The invention relates to an on-line detection method of near infrared spectrum for production process of traditional Chinese medicine, pill of six ingredients with rehmannia. The on-line detection method comprises the following steps: (1) selection of a calibration set sample; (2) property determination of the calibration set sample; (3) near infrared absorption spectrometry determination of the calibration set sample; (4) establishment of a calibration model; and (5) property determination of an unknown sample, namely leading a near infrared absorption spectrum value of the unknown sample into the calibration model established in the step (4) and then obtaining the content of target ingredients in the unknown sample after model calculation. The on-line detection method has the advantagesof simpleness, correction and good ruggedness, application for on-line quality control of the pill of six ingredients with rehmannia, and capability of resolving the problems of long time consumption,low efficiency and the like of the traditional off-line detection in production process.

Description

【Technical field】 [0001] The invention relates to the technical field of quality detection in the production process of traditional Chinese medicines, in particular to a near-infrared spectrum online detection method in the production process of the traditional Chinese medicine Liuwei Dihuang Pills. 【Background technique】 [0002] Liuwei Dihuang Wan is a famous prescription for invigorating the kidney. The earliest records can be traced back to "Pediatric Medicine and Syndrome Zhijue" written by Qian Yi, a famous doctor in the Northern Song Dynasty. Liuwei Dihuang Wan is composed of rehmannia glutinosa, dogwood, yam, Alisma, paeonol, and Poria cocos, and the ratio of each herb is 8:4:4:3:3:3. Liuwei Dihuang preparations are divided into decoctions, honeyed pills, oral liquids, concentrated pills, hard capsules and soft capsules, etc., and are widely used in clinical practice. [0003] At present, there are nearly 100 manufacturers producing Liuwei Dihuang products in China,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/20A61P1/14A61P13/12G01N21/35
Inventor 胡坪张敏罗国安章弘扬王月荣温海燕
Owner EAST CHINA UNIV OF SCI & TECH
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