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Technique for preparing new preparation of six ingredients with rehmannia

A Liuwei Dihuang, production process technology, applied in the direction of medical preparations containing active ingredients, drug delivery, plant raw materials, etc.

Inactive Publication Date: 2008-12-03
吴开敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, the new Liuwei Dihuang preparation can also be made into Liuwei Dihuang Wan with different components, but the name will be exactly the same as the existing Liuwei Dihuang Wan, etc., and there will be a phenomenon of two drugs with the same name in many preparations. Therefore, it is also necessary to reorganize the prescription The later Liuwei Dihuang preparation was renamed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Prepare the materials according to the proportion of each traditional Chinese medicine (the same below), take the Cortex Moutan and Digupi respectively and use CO2 supercritical fluid to extract the extract and dregs for later use; take Cornus officinalis and add ethanol for reflux extraction, filter, dregs for later use, and recover the filtrate Ethanol, concentrated to a thick paste; take the above-mentioned Moutan Cortex, Digu Cortex, Cornus officinalis medicinal residue, Rehmannia glutinosa, Chinese yam, Poria cocos, add water to decoct, filter, combine the filtrate, take the filtrate and use an ultrafiltration membrane with a molecular weight of 50,000-100,000 Gradient filtration and separation, discarding the supernatant of the membrane, and then using an ultrafiltration membrane of 0.1-0.3 million molecular weight for gradient filtration and separation of the filtrate to obtain a thick paste-like supernatant of the membrane, and the supernatant of the membrane is p...

Embodiment 2

[0020] Extract the Cortex Moutan and Digupi respectively with CO2 supercritical fluid, and the obtained extract and dregs are used for later use; take Cornus officinalis and add ethanol to reflux extraction, filter, and the dregs are used for later use, and the filtrate recovers ethanol and concentrates to a thick paste; Cortex Moutan, Digupi, Cornus officinalis, Rehmannia glutinosa, Chinese yam, and Poria cocos are decocted with water, filtered, and the filtrates are combined, and the filtrates are filtered and separated by ultrafiltration membranes with molecular weights of 50,000, 70,000, and 100,000, and discarded. The supernatant of the membrane is removed, and the filtrate is filtered and separated by ultrafiltration membranes with a molecular weight of 0.1 million, 2.000, and 3.00 million to obtain a thick paste-like membrane supernatant. The above-mentioned subfilm is passed through a macroporous resin column according to the existing technology, and the ethanol gradient...

Embodiment 3

[0022] Extract the Cortex Moutan and Digupi respectively with CO2 supercritical fluid, and the obtained extract and dregs are used for later use; take Cornus officinalis and add ethanol to reflux extraction, filter, and the dregs are used for later use, and the filtrate recovers ethanol and concentrates to a thick paste; Cortex Moutan, Digupi, Cornus officinalis, Rehmannia glutinosa, Chinese yam, and Poria cocos are decocted with water, filtered, and the filtrate is combined. The filtrate is filtered and separated with a 50,000-molecular-weight ultrafiltration membrane. The supernatant of the membrane is discarded, and the filtrate is Then use an ultrafiltration membrane with a molecular weight of 0.3 million to filter and separate to obtain a thick paste-like membrane liquid. The above-mentioned membrane liquid passes through a macroporous resin column and ethanol gradient elution, collects the eluate, recovers ethanol, and concentrates to a thick paste. , add the above-mentio...

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Abstract

Ancient prescription liu-wei tonic pills frequently cause a plurality of untoward effects due to alisma orientale in compositions; and the dosage is large, and the treatment effect can only be achieved by taking 8 granules at a time, which can not meet the requirement of the China Pharmacopoeia Committee that 'only 2 granules are required for taking'. The invention relates to novel liu-wei tonic preparation, which is a novel medicine prepared by replacing the alisma orientale in preparation such as the liu-wei tonic pills and so on into cortex lycii radicis. The novel liu-wei tonic preparation adopts the CO2 supercutical fluid extraction method and utilizes manufacturing techniques such as the technology for gradient filtration and separation through an ultrafiltration membrane, improves the yield, avoids damage of high temperature on effective ingredients, has high bioavailability, and also can remove a plurality of impurities and ineffectual ingredients and greatly reduce the dosage. Because the novel liu-wei tonic preparation produced by any method can prepare various preparation types which are the same as the prior liu-wei tonic preparation, the homonymy phenomena of the novel medicine and the prior medicine can occur certainly, 'novel' is named before the prior name as for improved novel products, i.e. named as novel liu-wei tonic pills, novel liu-wei tonic tablets, novel liu-wei tonic capsules and so on.

Description

technical field [0001] The invention relates to a production process and drug name of a new Liuwei Dihuang preparation, belonging to the field of traditional Chinese medicines. Background technique [0002] The existing Liuwei Dihuang Wan is an ancient famous medicine that has been used for hundreds of years, and has a high clinical reputation. It is composed of six traditional Chinese medicines including Rehmannia glutinosa, Cornus officinalis, Chinese yam, Poria cocos, Moutan cortex and Alisma alisma. The best-selling drug for strengthening the body. [0003] For decades, there have been literatures pointing out that gastroenteritis, nausea, vomiting, dizziness, dizziness, abdominal pain, diarrhea, weakness of limbs, loss of appetite, itching, allergic rash, angioneurotic edema, and even respiratory paralysis occur after taking Liuwei Dihuang Pills. The symptoms of poisoning are mainly caused by Alisma in the medicine. Modern research has found that the whole plant of A...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/00A61P1/14A61P13/12
Inventor 吴开敏
Owner 吴开敏
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