Method of preparing concentrated pill of six ingredients with rehmannia

A technology of Liuwei Dihuang Pills and Cortex Moutan, which is applied in the field of preparation of concentrated Liuwei Dihuang Pills, can solve the problems of easy errors, troublesome patients taking medicine, and large number of takings

Active Publication Date: 2008-02-27
TAIJI GRP CHONGQING NO 2 CHINESE MEDICINE FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the small particle size of the original pill, the drug is taken in large quantities, which makes it both troublesome and prone to errors for patients to take the medicine, which affects the curative effect

Method used

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Examples

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Effect test

preparation example Construction

[0015] The preparation method of the concentrated Liuwei Dihuang Pills of the present invention includes pretreatment, batching, milling and extraction of raw medicinal materials according to the standard. Concentrate the extracted filtrate to a relative density of 1.38-1.40 / 75°C, add ethanol or a disintegrating agent, and select an appropriate drying process to finally obtain a water content of 5-8%, a dissolution time limit of 55-120 minutes, and a dry pellet weight 0.425g~0.445g / pill, pills with a dry diameter of 8.5~9.2mm / pill.

[0016] According to the quality standards of Liuwei Dihuang Pills in the "Chinese Pharmacopoeia", although the amount of Chinese medicinal materials powdered into the powder is constant, during the extraction process, the difference between batches of medicinal materials will lead to differences in the amount of thick paste in each batch, which in turn will lead to the difference between batches of finished pills. There are certain differences in ...

Embodiment 1

[0027] Prescription: Rehmannia glutinosa 320g, Cornus officinalis (made) 160g, Peony 120g, Chinese yam 160g, Poria cocos 120g, Alisma 120g.

[0028] The preparation process is as follows: according to the prescription, take nine medicinal materials such as Rehmannia glutinosa, Cornus officinalis, Peony, Chinese yam, Poria cocos and Alisma alisma, extract paeonol from Moutan cortex; Decoction twice, each time for two hours, the filtrate is concentrated to a thick paste with a density of 1.32-1.40, the yam and the remaining dogwood are crushed into fine powder, sieved, and mixed; then the above thick paste, fine powder, paeonol , Auxiliary material mixing, the 93% ethanol that adds is made soft material, and the amount of adding ethanol is 1.2% of fine powder, medicinal extract, paeonol total amount, makes wet pill, and average pill weight is 0.477g / pill, adopts oven Dry with vibration drying, polish, get average ball diameter 8.5mm / ball, average ball weight is the product 100...

Embodiment 2

[0030]Prescription: Rehmannia glutinosa 320g, Cornus officinalis (made) 160g, Peony 120g, Chinese yam 160g, Poria cocos 120g, Alisma 120g.

[0031] The preparation process is as follows: according to the prescription, take nine medicinal materials such as Rehmannia glutinosa, Cornus officinalis, Peony, Chinese yam, Poria cocos and Alisma alisma, extract paeonol from Moutan cortex; Decoction twice, each time for two hours, the filtrate is concentrated to a thick paste with a density of 1.32-1.40, the yam and the remaining dogwood are crushed into fine powder, sieved, and mixed; then the above thick paste, fine powder, paeonol , auxiliary material mixing, the 95% ethanol that adds is made soft material, and the amount of adding ethanol is 1.5% of fine powder, extractum, paeonol total amount, makes wet pill, and average pill weight is 0.483g / pill, adopts microwave Drying with an oven, polishing, to get an average pill diameter of 9.2mm / pill, and an average pill weight of 1000 p...

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Abstract

The invention discloses a making method of concentrated Bolus of Six Drugs Including Rehmannia, which comprises the following steps: fetching prepared rehmannia root, Cornaceae, moutan bark, Dioscorea japonica, poria cocos wolf and Alismatales as raw materials; extracting paeonol from bark of peony root; adding dregs of a decoction, Cornaceae, prepared rehmannia root, poria cocos wolf and Alismataceae into water to boil; condensing filtrate into plaster; grinding Dioscorea japonica and residual Cornaceae powder into flour; sieving; blending evenly; blending the plaster, flour and paeonol evenly; pelletizing; drying; polishing; obtaining the plaster with relative density at 1. 38-1. 40 / 75 deg. c; controlling the dried pill weight at 0. 425g-0. 445g / pill and diameter at 8. 5-9. 2mm / pill; adding alcohol or disintegration agent to modify the drying technique. The invention converses 3 pills as norm as original 3g drug to satisfy the request of inner quality and appearance, which reduces the dosage for patient with convenient intake.

Description

【Technical field】 [0001] The invention relates to a method for preparing traditional Chinese medicine, in particular to a method for preparing concentrated Liuwei Dihuang Wan. 【Background technique】 [0002] Liuwei Dihuang Pill is a traditional Chinese patent medicine that has the function of nourishing yin and tonifying kidney, and is used for kidney yin deficiency, dizziness and tinnitus, sore waist and knees, bone steaming hot flashes, night sweats and nocturnal emission, and quenching thirst. The process of preparing Liuwei Dihuang Pills in the prior art is as follows: take rehmannia glutinosa, dogwood (made), moutan cortex, yam, Poria cocos and Alisma alisma, extract paeonol from moutan cortex; , Poria cocos and Alisma alisma and decoct twice, then concentrate the filtrate to a thick paste with a relative density of 1.35-1.40; powder, paeonol, and auxiliary materials are mixed, and pelletized, dried, and polished to obtain concentrated pills equivalent to 3g of the ori...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K9/20A61K47/38A61P1/14
Inventor 顾维菊程地英胡红英唐利国卿玉玲吕勇均
Owner TAIJI GRP CHONGQING NO 2 CHINESE MEDICINE FACTORY
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