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Quality control method for liuwei Dihuang soft extract

A quality control method, Liuwei Dihuang technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of catalpol instability when exposed to heat, difficulty in controlling the quality of Liuwei Dihuang paste, and large limitations

Active Publication Date: 2005-04-27
JIANGZHONG PHARMA
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Problems solved by technology

[0002] "Drug Standards of the Ministry of Health of the People's Republic of China" (Prescriptions of Traditional Chinese Medicine) Volume III (WS 3 -B-2489-97), the medicine for nourishing yin and tonifying kidney, Liuwei Dihuang Paste, is a paste made from 320g of Rehmannia glutinosa, 160g of Cornus officinalis (manufactured), 160g of Chinese yam, 120g of Moutan cortex, 120g of Poria cocos, and 120g of Alisma. And promulgated the Liuwei Dihuang Paste quality control standard, but in the existing Liuwei Dihuang Paste quality control method issued by the Ministry of Health, there is only TLC identification of paeonol in Cortex Moutan and no content determination method, which has great limitations and is difficult to Control the quality of Liuwei Dihuang paste; paeoniflorin is another active ingredient in Cortex Moutan, which has analgesic, antispasmodic, antibacterial, and anti-inflammatory effects; other Liuwei Dihuang preparations (with content determination) ) are for the determination of paeonol in Moutan Cortex and ursolic acid in Cornus officinalis; in addition, the article "Determination of Catalpol in Liuwei Dihuang Pills" published by Liu Changhe et al. Alcohol is used as an index to control the quality of this class of preparations, and it is pointed out that catalpol has unstable properties when encountering heat; "High performance liquid chromatography is used to determine the paeonol in Liuwei Dihuang capsules" published by Zhang Zhongchun, etc. In the article "High Performance Liquid Chromatography" it is proposed to use high performance liquid chromatography to determine paeonol; in the article "Improvement of the Determination Method of Ursolic Acid in Liuwei Dihuang Pills" published by You Huilian et al. The problems existing in the determination of ursolic acid content by tomography method were tested and discussed; "RP-HPLC method to determine the content of loganin in Liuwei Dihuang pills" published by Chen Hexin et al. The intrinsic quality of this formulation provides new and reliable means of

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  • Quality control method for liuwei Dihuang soft extract

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Comparison scheme
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Embodiment 1

[0095] Embodiment 1: Get 320g of Chinese herbal rehmannia glutinosa, 160g of Cornus officinalis (made), 160g of Chinese yam, 120g of Moutan cortex, 120g of Poria cocos, 120g of Alisma, add water to decoct the above-mentioned raw materials for three times, add 9 times the amount of water for the first and second times, Decoct for 2 hours, add 7 times the amount of water for the third time, decoct for 1 hour, combine the decoction, filter, let the filtrate stand, take the supernatant and concentrate it under reduced pressure to a clear liquid with a relative density of 1.28-1.32 (85°C). Ointment, add 300g of refined honey for every 100g of clear ointment, mix well, and get it.

[0096] 1. Use high performance liquid chromatography (Chinese Pharmacopoeia 2000 edition an appendix VID) to measure the content of paeoniflorin and its standards:

[0097] a. Chromatographic conditions: use octadecylsilane bonded silica gel as the filler; acetonitrile-water (12:88) as the mobile phase, ...

Embodiment 2

[0105] Embodiment 2: Get 320g of Chinese herbal medicine Rehmannia glutinosa, 160g of Cornus officinalis (made), 160g of Chinese yam, 120g of Moutan cortex, 120g of Poria cocos, 120g of Alisma, add water to decoct the above-mentioned raw materials for three times, add 9 times the amount of water for the first and second times, Decoct for 2 hours, add 7 times the amount of water for the third time, decoct for 1 hour, combine the decoction, filter, let the filtrate stand, take the supernatant and concentrate it under reduced pressure to a clear liquid with a relative density of 1.28-1.32 (85°C). paste. Add 300g of refined honey for every 100g of clear ointment, mix well, and you get it.

[0106] 1. Use high performance liquid chromatography (Chinese Pharmacopoeia 2000 edition an appendix VID) to measure the content of paeoniflorin and its standards:

[0107] a. Chromatographic conditions: use octadecylsilane bonded silica gel as filler; acetonitrile-water (10:90) as mobile phas...

Embodiment 3

[0115] Embodiment 3: Get 320g of Chinese herbal rehmannia glutinosa, 160g of Cornus officinalis (made), 160g of Chinese yam, 120g of Moutan cortex, 120g of Poria cocos, 120g of Alisma, add water to decoct the above-mentioned raw materials for three times, add 9 times the amount of water for the first and second times, Decoct for 2 hours, add 7 times the amount of water for the third time, decoct for 1 hour, combine the decoction, filter, let the filtrate stand, take the supernatant and concentrate it under reduced pressure to a clear liquid with a relative density of 1.28-1.32 (85°C). paste. Add 300g of refined honey for every 100g of clear ointment, mix well, and you get it.

[0116] 1. Use high performance liquid chromatography (Chinese Pharmacopoeia 2000 edition an appendix VID) to measure the content of paeoniflorin and its standards:

[0117] a. Chromatographic conditions: use octadecylsilane bonded silica gel as a filler; acetonitrile-water (15:85) is the mobile phase, ...

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Abstract

The present invention is the new quality control method for Rehmanniae ointment of six ingredients. The medicine Rehmanniae ointment of six ingredients is prepared with six kinds of Chinese medicinal materials, including prepared rhizome of rehmannia, dogwood, Chinese yam, tree peony bark, tuckahoe and oriental water plantain. The quality control method includes the high efficiency liquid phase chromatographic process to measure the content of paeoniflorin and the thin-layer chromatographic process to identify dogwood, and the method is accurate and advanced.

Description

technical field [0001] The invention relates to a quality control method of Liuwei Dihuang Paste, a medicine for nourishing yin and tonifying kidney, which is made from Chinese medicinal materials Rehmannia glutinosa, Cornus officinalis (manufactured), Chinese yam, Moutan cortex, Poria cocos and Alisma alisma, and specifically relates to the determination of the medicine by high performance liquid chromatography The content of paeoniflorin in Chinese herbal medicine and the quality control method of Liuwei Dihuang Paste of Chinese medicinal material Cornus officinalis identified by thin-layer chromatography. Background technique [0002] "Drug Standards of the Ministry of Health of the People's Republic of China" (Prescriptions of Traditional Chinese Medicine) Volume III (WS 3 -B-2489-97), the medicine for nourishing yin and tonifying kidney, Liuwei Dihuang Paste, is a paste made from 320g of Rehmannia glutinosa, 160g of Cornus officinalis (manufactured),...

Claims

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Application Information

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IPC IPC(8): G01N30/00G01N30/02G01N30/06G01N30/28G01N30/86G01N30/88G01N30/90
Inventor 季巧遇李诒光徐昌瑞
Owner JIANGZHONG PHARMA
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