Extractive from decoction of rehmannia including six elements, combination of medication, and medical use

A technology of Liuwei Dihuang Decoction and its extract, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problem of inability to guarantee the effectiveness of clinical medication, unclear active ingredients, and difficulty in ensuring stable and reliable product quality. Control and other issues

Active Publication Date: 2005-06-15
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But at present, in the actual application of this prescription, no matter it is used as decoction, pill, capsule or other dosage forms, there are obvious deficiencies, which are mainly manifested in the following aspects: one is that the dosage is large, and it is inconvenient to take medicine, and it is difficult to make a medicine that is convenient to use. dosage form; second, the active ingredients are not clear, and t

Method used

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  • Extractive from decoction of rehmannia including six elements, combination of medication, and medical use
  • Extractive from decoction of rehmannia including six elements, combination of medication, and medical use
  • Extractive from decoction of rehmannia including six elements, combination of medication, and medical use

Examples

Experimental program
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Effect test

Embodiment 1

[0154] Embodiment 1: Preparation of Liuwei Dihuang Decoction Extract LW-ABC

[0155] According to the ratio of the single ingredients of Liuwei Dihuang Decoction, that is, Rehmannia glutinosa: Cornus officinalis: Chinese yam: Alisma: Alisma: Cortex paeonol: Poria (8:4:4:3:3:3) or after adding or subtracting some of the herbs, A total of 1500 grams of crude drugs are added, boiled twice in boiling water with six times the weight of crude drugs, each time for two hours, filtered with gauze (six layers) and absorbent cotton, concentrated under reduced pressure until the ratio of crude drug (weight) to extract (volume) is 1: 1.

[0156] Add ethanol to the extract with stirring to a final ethanol concentration of 30% (v / v), stir, and place overnight. Centrifuge (2500 rpm, 25 min). The precipitate was washed 4 times with 30% ethanol, centrifuged, and the precipitate was discarded. The supernatants were combined and concentrated to 1000 ml, and the final ethanol concentration was ...

Embodiment 2

[0159] Embodiment 2: Experiment of biological activity of the extract LW-ABC of Liuwei Dihuang Decoction of embodiment 1

[0160] 1. The effect of LW-ABC on immune function

[0161] 1. The effect of LW-ABC on the immune function of "kidney yin deficiency" mice

[0162] The preparation of the "kidney yin deficiency" mouse model was carried out as follows: Balb / c mice were subcutaneously injected with corticosterone suspension, 25 mg / kg, 2 times / day, for 7 consecutive days. Liuwei Dihuang Tang or the active ingredient composition LW-ABC of Liuwei Dihuang Tang was given by intragastric administration on the day of the test, once a day for 7 consecutive days, and the experiment was carried out 4 hours after the last administration. The mice were decapitated after weighing, and the thymus and spleen were removed, weighed, and the index of thymus and spleen was calculated. During the lymphocyte proliferation reaction experiment, the mice were decapitated, and the spleen was taken ...

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Abstract

Liuwei Dihuang Decoction extract, comprising 11.4-17% by weight of polysaccharides, and/or 1.85-2.27% by weight of total glycosides (morroniside, loganin, paeoniflorin) and /or 23.5-35.5% by weight of mannotriose, wherein Liuwei Dihuang Decoction is composed of six traditional Chinese medicines of Rehmannia glutinosa, Cornus officinalis, Chinese yam, Alisma, Paeonol and Poria cocos in a weight ratio of 8:4:4:3:3:3.

Description

technical field [0001] The present invention relates to Liuwei Dihuang Decoction extract (abbreviated as LW-ABC), its extraction method, pharmaceutical composition containing the extract and its medical application. The medical application includes the application of treatment or auxiliary treatment of diseases, and the diseases involved include Tumors, side effects of tumor chemotherapy or radiotherapy, leukopenia, senile immune dysfunction, infection, etc.; autoimmune diseases such as systemic lupus erythematosus, nephrotic syndrome, nephritis, bronchitis and bronchial asthma, prostatitis, aplastic Immune dysfunction in patients with anemia, thrombocytopenic purpura, myasthenia gravis, and senile diseases; and reproductive endocrine dysfunction or disorders associated with kidney yin deficiency, including menopausal syndrome, ovarian hypofunction, infertility , habitual abortion, autonomic disorder, chloasma, gynecomastia, senile sexual decline, menopausal osteoporosis, seni...

Claims

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Application Information

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IPC IPC(8): A61P7/06A61P11/00A61P13/08A61P13/12A61P15/12A61P19/10A61P21/04A61P35/00A61P37/04
Inventor 赵毅民乔善义张永祥周文霞马渊齐春会董剑英孙磊程军平赵修南童静任凤霞熊善丽郭继芬
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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