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Liuwei Dihuang decoction total extract composition and preparation method and application thereof to preparation of drugs for treating heart, brain and testis complications caused by stress response

A technology of Liuwei Dihuang Decoction and extract, which is applied in the direction of drug combination, medical formula, plant raw materials, etc.

Inactive Publication Date: 2012-09-05
ZHEJIANG CHINESE MEDICAL UNIV MEDICAL PIECES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Patent Application No. "200410062502.3" The preparation method of Liuwei Dihuang preparation takes into account the polysaccharide components and fat-soluble ingredients, but this method is only used in the Liuwei Dihuang prescription Some medicines are extracted with alcohol, not as a whole, and some fat-soluble active ingredients are lost

Method used

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  • Liuwei Dihuang decoction total extract composition and preparation method and application thereof to preparation of drugs for treating heart, brain and testis complications caused by stress response
  • Liuwei Dihuang decoction total extract composition and preparation method and application thereof to preparation of drugs for treating heart, brain and testis complications caused by stress response
  • Liuwei Dihuang decoction total extract composition and preparation method and application thereof to preparation of drugs for treating heart, brain and testis complications caused by stress response

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] Add rehmannia glutinosa, cornus officinalis (made), yam, Alisma, Moutan cortex and Poria cocos in Liuwei Dihuang Decoction according to the ratio of 8:4:4:3:3:3 (total 1680g), add 10 times the amount of water, soak for 3 hours, Decoct twice, recover volatile oil at the same time, each time for 30 minutes, filter with gauze, concentrate under reduced pressure to a clear paste, the relative density of the clear paste is 1.10-1.25 (50°C), and the remaining medicinal residue after filtration is used for later use; β-cyclopaste After being refined into a saturated aqueous solution, slowly drop the volatile oil into the saturated aqueous solution of β-cyclodextrin and keep stirring, put it under refrigeration (4°C) for 48 hours, then filter it with suction, and dry it at 40°C to obtain the volatile oil β-cyclodextrin Clathrate (5.76g). Add ethanol to the clear paste and keep stirring until the amount of ethanol is 70%, put it in the refrigerator at 4°C for 48 hours, separate ...

Embodiment 2

[0144] Example 3 is basically the same as Example 1, but with the following changes: the raw material is composed of Rehmannia glutinosa, Cornus officinalis, Chinese yam, Alisma, Cortex Moutan and Poria according to the weight ratio of 7.6:2.8:2.8:2.1:2.1:2.1, Among the raw materials, the rehmannia glutinosa, cornel officinalis and Chinese yam are selected products.

Embodiment 3

[0145] Example 4 is basically the same as Example 1, but with the following changes: the bulk drug is composed of Rehmannia glutinosa, Cornus officinalis, Chinese yam, Alisma, Cortex Moutan and Poria according to the weight ratio of 10.4:2.8:5.2:2.1:3.9:2.1, Among the raw materials, the above-mentioned rehmannia glutinosa and dogwood are selected products; Chinese yam is selected raw products.

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Abstract

The invention provides a Liuwei Dihuang decoction total extract composition and a preparation method and application thereof to preparation of drugs for treating heart, brain and testis complications caused by stress response. The composition comprises the active pharmaceutical ingredients including radix rehmanniae praeparata, prepared fructus corni, Chinese yam, rhizoma alismatis, cortex moutan and Indian buead in a weight ratio of 8:4:4:3:3:3. The composition is characterized in that the composition comprises an essential oil beta-cyclodextrin inclusion compound ingredient, a polysaccharide ingredient, a glucoside ingredient and a fat soluble ingredient of a Liuwei Dihuang decoction total extract. The composition and the preparation method have the following beneficial effects: the defect that the fat soluble active ingredients of the Liuwei Dihuang decoction total extract are neglected in the prior art is overcome; the more complete ingredient composition of the Liuwei Dihuang decoction total extract is obtained through the extraction process; and the composition is possibly used to treat the heart, brain and testis complications caused by stress response.

Description

[0001] technical field [0002] The present invention relates to a traditional Chinese medicine composition, in particular to a total extract composition of Liuwei Dihuang Decoction, a preparation method of the total extract composition of Liuwei Dihuang Decoction, and the application of the total extract composition of Liuwei Dihuang Decoction in preparation The application of drugs in the heart, brain, testis and other complications of irritating reactions. technical background [0003] Liuwei Dihuang Decoction originated from the "Children's Medicine Syndrome Zhijue" written by Qian Yi, a medical scientist in the Song Dynasty. Yin" basic prescription. Its formula has the characteristics of three tonics and three diarrhea: Liuwei Dihuang Decoction reuses rehmannia glutinosa to nourish yin and kidney, replenish essence and marrow, and is the king's medicine. Cornus officinalis nourishes the liver and kidney, and can astringe the essence, which means that the liver and ki...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P39/00A61P43/00
Inventor 张云戴德哉丛晓东戴茵王胜波
Owner ZHEJIANG CHINESE MEDICAL UNIV MEDICAL PIECES
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