Osmotic pump type controlled release preparation of liuweidihuang or its adjusted formula extract and its preparing method

Abstract

The present invention relates to an osmotic pump controlled-release preparation of Liuwei Dihuangwan pills or its variant prescription extract. It is characterized by that it is formed from several portions of osmotic pump tablet core, coating film and medicine-releasing hole, in which the osmotic tablet core includes 5%-70% of Liuwei Dihuang or its variant prescription active extract and 5%-90% of auxiliary material capable of making active extract be easily released. The described extract is one kind selected from Liuwei Dihuang extract, Zhibai dihuang extract, Maiwei Dihuang extract, Gouju dihuang extract, Mingmu Dihuang extract and Guifu Dihuang extract. It can be made into tablet, capsule, suppository and other dosage forms, then made into various osmotic pump preparation.s

Description

1. Technical field [0001] An osmotic pump-type controlled-release preparation of Liuwei Dihuang or its modified extracts and a preparation method thereof relate to the technical field of medicine. 2. Background technology [0002] In recent years, the formulations of traditional Chinese medicine have made great progress. Since the 1950s, Chinese medicine tablets, injections, liniments, granules, smears and aerosols have been successfully used in clinical practice; from the late 1970s to the mid-1980s, a large number of effective Chinese herbal medicines were discovered And effective parts, active ingredients, and made into tablets, injections, liniments, granules, etc.; since the late 1980s, new dosage forms have emerged, including capsules (including soft capsules), granules, oral liquids, and pills (including micropills and dropping pills), intravenous emulsions and suspensions, traditional Chinese medicine transdermal preparations, traditional Chinese medicine microcapsul...

AI Technical Summary

Problems solved by technology

In addition, the timed, directional, and constant-rate drug release system successfully used in western medicine—the controlled release and targeted drug delivery system has been launched in traditional Chinese medicine preparations, but currently it is limited to the research of single components of traditional Chinese medicine. For Chinese medicine extracts and traditional Chinese medicine The research on compound sustained and controlled release system has not been reported at home and abroad

[0003] At present, the research and development of oral sustained and controlled release solid preparations mainly include membrane-controlled diffusion, matrix-type sustained and controlled release preparations, pulsed drug release systems, and colon-localized drug delivery systems, but there are few dosage forms that can be applied to traditional Chinese medicine compound preparations. Due to the complex ingredients and different properties in the compound preparation of traditional Chinese medicine, according to the holistic view of traditional Chinese medicine theory and the comprehensiveness of syndrome differentiation and treatment, in order to make it achieve comprehensive therapeutic effect, each component must be released at the same time, but it is difficult to achieve it with the above drug release systems. Therefore, how to adopt new methods, new technologies, new excipients, and new equipment of modern preparations as much as possible to create new dosage forms suitable for the characteristics of traditional Chinese medicine, especially the quick-acting and sustained-release preparations of traditional Chinese medicine compounds, and formulate scientific and strict quality control measures. Control standards, so as to achieve "safe, effective, stable and controllable", is a difficult problem before us

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