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Chinese medicinal biological agent of 'Liu Wei Di Huang' decoction and preparation process thereof

A technology of Liuwei Dihuang decoction and biological preparation, which is applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc. degree of effect

Inactive Publication Date: 2007-05-30
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reason is that Western medicine is a single drug with a small molecular weight and is easy to enter human cells, so the treatment of the lesion is more direct and quick-acting; while Chinese medicine is a compound (group) drug with a large molecular weight and is a mixture of various chemical components. The function and mechanism of action of each component at the cellular and molecular levels has not yet been clarified, so it is slow to take effect in the treatment of diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 6

[0020] The preparation of embodiment 1 Liuwei Dihuang Decoction Chinese medicine biological preparation

[0021] Cook 20g of rehmannia glutinosa, 30g of cornus officinalis, 55g of Chinese yam, 15g of Alisma, 50g of cortex moutan, and 30g of poria cocos, decoct with water and concentrate to a concentration of 0.5g / ml; take 4 parts of soybean milk, ferment, and filter to obtain soybean milk fermentation liquid; Add the fermented soybean milk liquid to the water decoction of Liuwei Dihuang Decoction, adjust the pH to neutral; inoculate purple non-sulfur bacteria (Rhodospirillum) into Liuwei Dihuang Decoction, and ferment for 2 months at 30°C under light conditions. The obtained liquid medicine is separated, extracted, refined, sterilized and made into an oral preparation.

Embodiment 2 6

[0022] The preparation of embodiment 2 Liuwei Dihuang Decoction Chinese medicine biological preparation

[0023] Cook 70g of rehmannia glutinosa, 50g of cornus officinalis, 25g of Chinese yam, 45g of Alisma, 12g of Moutan cortex, and 50g of Poria cocos, decoct with water and concentrate to a concentration of 1.5g / ml; take 7 parts of soybean milk, ferment, and filter to obtain soybean milk fermentation liquid; Add the soymilk fermented liquid to the water decoction of Liuwei Dihuang Decoction, adjust the pH to 10; inoculate purple non-sulfur bacteria (Rhodobacteria) into Liuwei Dihuang Decoction, ferment for 5 months at 28°C under light conditions, and obtain the medicine The liquid is separated, extracted, refined, sterilized, spray-dried into capsules or freeze-dried to make solid tablets.

Embodiment 3

[0024] Embodiment 3 Treatment of Kidney Yin Deficiency Syndrome Experiment

[0025] NIH mice were used, half male and half male, and randomly divided into normal group, model group, Liuwei Dihuang Decoction group, photosynthetic bacteria group, photosynthetic bacteria plus Liuwei Dihuang Decoction group. Except for the normal control group, the animals in the other groups were given thyroxine 3 mg and reserpine 0.02 mg per day by intragastric administration, once a day, for 7 consecutive days. Once, for 7 consecutive days, the symptoms, body weight, and the number of live animals in the 7 days were observed every day. The animals were killed by dislocation 1 hour after the last administration, and the spleen and thymus were weighed to calculate the visceral index. The results are shown in Table 1, showing that Liuwei Dihuang Decoction, photosynthetic bacteria plus Liuwei Dihuang Decoction group can significantly improve the signs of yin deficiency model (virtual phenomena such...

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Abstract

The invention relates to a Chinese medicinal preparation of Six-Ingredient Rehmannia Decoction and process for preparation which comprises grilling herbs of Six-Ingredient Rehmannia Decoction and concentrating to a concentration of 0.2-2g / ml, fermenting soybean milk 4-8 parts and filtering, charging soybean milk fermentation liquor into water grilling liquid, adjusting pH=6-10, inoculating photosynthetic bacterium into the decoction, fermenting under the temperature of 10-30 deg. C for 1-5 months, isolating the soup, extracting, refining and sterilizing.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine biological preparation of Liuwei Dihuang Decoction and a preparation method thereof. Background technique [0002] Traditional Chinese medicine, which is rooted in Chinese traditional culture, has a history of thousands of years of development, while Western medicine has a history of only more than a hundred years. However, in the modern medical system, Western medicine still dominates. The reason is that Western medicine is a single drug with a small molecular weight and is easy to enter human cells, so the treatment of the lesion is more direct and quick-acting; while Chinese medicine is a compound (group) drug with a large molecular weight and is a mixture of various chemical components. The function and mechanism of action of each component at the cellular and molecular levels has not yet been clarified, so it is slow to take effect ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/48A61P1/14A61P13/12
Inventor 赵越
Owner GUANGDONG PHARMA UNIV
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