Micropills of corylus heterophylla leaf extract and preparation method thereof

A technology of extracts and pellets, applied in the field of medicine, can solve the problem of low yield

Inactive Publication Date: 2012-11-21
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a kind of hazel leaf extract pellets that can be used for anti-oxidation, and its preparation method, to overcome the problem that the yield of pellets is lower in the coating process

Method used

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  • Micropills of corylus heterophylla leaf extract and preparation method thereof
  • Micropills of corylus heterophylla leaf extract and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] The steps for preparing the extract of the present invention are as follows:

[0098] 1), get 40g flat hazel leaf powder, 20 mesh;

[0099] 2), the extraction raw material is crushed, and 10% ethanol is used as the extraction solution, and the extraction is refluxed at 90° C. to obtain the extract (in this extraction step, the solid-liquid ratio of the reflux extraction is 1:5, and the extraction is performed 3 times, each extraction for 2 hours);

[0100] 3), the extract of step 2) is purified by a macroporous resin, and the macroporous resin is first eluted with water until the outflowing liquid is colorless, then eluted with 60% ethanol as the eluent, and passed through the FRAP method Detecting and collecting fractions eluted from the eluent, the macroporous adsorption resin is HPD-100;

[0101] 4), evaporate and recover the solvent of the eluted fraction, and dry to obtain final product.

[0102] After calculation and determination: yield 3.85%; total flavonoid ...

Embodiment 2

[0104] The steps for preparing the extract of the present invention are as follows:

[0105] 1), get 40g hazel leaf powder, 80 mesh;

[0106] 2), the extraction raw material is pulverized, and 30% ethanol is used as the extraction solution, and reflux extraction is performed at 50° C. to obtain an extract (in this extraction step, the ratio of solid to liquid for reflux extraction is 1: 2, and the extraction is performed twice, each extraction for 3 hours);

[0107] 3), the extract of step 2) is purified by a macroporous resin, and the macroporous resin is first eluted with water until the outflowing liquid is colorless, then eluted with 65% ethanol as the eluent, and passed through the FRAP method Detect and collect the fractions eluted from the eluent, the macroporous adsorption resin is HPD-700;

[0108] 4), evaporate and recover the solvent of the eluted fraction, and dry to obtain final product.

[0109] After calculation and determination: the yield is 2.65%; the tota...

Embodiment 3

[0111] The steps for preparing the extract of the present invention are as follows:

[0112] 1), get 40g flat hazel leaf powder, 40 mesh;

[0113] 2), the extraction raw material is crushed, and 20% ethanol is used as the extraction solution, and the extraction is refluxed at 70°C to obtain the extract (in this extraction step, the ratio of solid to liquid for the reflux extraction is 1:10, and the extraction is performed twice, each time extraction for 1 hour);

[0114] 3), the extract of step 2) is purified by a macroporous resin, and the macroporous resin is first eluted with water until the outflowing liquid is colorless, then eluted with 50% ethanol as the eluent, and passed through the FRAP method Detect and collect the fractions eluted from the eluent, the macroporous adsorption resin is HPD-400;

[0115] 4), evaporate and recover the solvent of the eluted fraction, and dry to obtain final product.

[0116] After calculation and determination: the yield is 6.72%; the t...

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Abstract

The invention relates to micropills of corylus heterophylla leaf extract and a preparation method thereof. The micropills comprise the following components in part by weight: 30 to 90 parts of corylus heterophylla leaf extract, 10 to 75 percent of diluent, 0.5 to 10 percent of disintegrating agent and an optional bonding agent. The invention also relates to coating micropills containing the micropills and a preparation method for the micropills. In the micropills, a slow and controlled release or enteric micropill preparation can be prepared by combining the sustained release or enteric micropill technology. The varieties and ratio of main ingredients and minor ingredients of the micropill preparation are reasonable, so the micropill preparation has the advantages of high yield, dissolution rate and bioavailability, small side effect and the like, is stable and safe, and / or is convenient to administrate.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pellet of hazel leaf extract and a preparation method thereof, in particular to a pellet made of hazel leaf extract which can be used for anti-aging and anti-oxidation and a preparation method thereof. Background technique [0002] Antioxidant substances (antioxidants) refer to a class of substances that can scavenge oxygen free radicals, inhibit or eliminate and slow down oxidation reactions. The development and research of antioxidants has always been widely concerned by people, especially when scientists discovered that the disease and aging of organisms are the result of free radicals in organisms, the research of antioxidants has a broad space for development. Antioxidants can be derived from organisms, including animals, plants, microorganisms, etc., which are usually called natural antioxidants or biological oxidants; some antioxidants can also be obtained by chemical synthesis, wh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K9/16A61K47/38A61K47/36A61K47/32A61P39/06A61K127/00
Inventor 金涛刘利群邹积宏
Owner HEILONGJIANG UNIV
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