Medicament composition for treating colpitis symptoms and preparation method thereof

Abstract

The invention relates to a drug combination for curing the inflammation of vagina, which adopts the form of a foaming agent, in particular to a foaming agent with the principle agents being metronidazole, clotrimazole and chlorhexidine acetate. The drug combination has the advantages of even distribution, wide coating area and better effect in the vagina by adopting the form, and meanwhile, the drug combination feels more comfortable and has stronger retention property than other forms. In the formula of the foaming agent, the drug combination can permeate into the mucosal folds of the vagina rapidly and effectively by dispersing atomizing particles with the particle diameter being a few micrometers in a foaming manner under the action of pressure; the drug combination has higher absorption rate than the spraying agent with water being the only solvent with the assistance from various fat-soluble auxiliary materials; the drug contamination and the cross contamination are avoided during the administration; the invention has the advantages that the curative effect is fully produced, the administration is sanitary, convenient, safe and reliable without causing the foreign body sensation, and the drug combination is easily accepted by patients; and the invention further has the advantages of drug stability, form stability and long effective duration.

Description

technical field [0001] The invention relates to the reform of traditional dosage forms of medicines, in particular to a novel compound foaming agent using metronidazole, clotrimazole and chlorhexidine acetate as main ingredients and a preparation method thereof. Background technique [0002] Bacterial vaginitis, fungal vaginitis, trichomonas vaginitis and bacterial fungal trichomonas mixed infection vaginitis are common and frequently-occurring diseases in women, which seriously affect women's health. [0003] At present, metronidazole, cotrimecilazole, and chlorhexidine acetate single-component are used as antibacterial and anti-inflammatory dosage forms, but the single component lacks synergistic effect, especially for the treatment of mixed infections. The Shuangzotai suppository (recorded in the second part of the Chinese Pharmacopoeia 2000 edition) prepared from the drug compound of metronidazole, clotrimazole and chlorhexidine acetate, has been clinically used for many...

AI Technical Summary

Problems solved by technology

However, the above listed dosage forms and patent reported dosage forms and their preparation methods generally have disadvantages such as backward dosage forms, low bioavailability, and inconvenient use. Regular and sleek, it is used in winter, and the vagina is often damaged during the process of being inserted into the vagina; in summer, it is easy to melt and stick to hands; and the suppository is easy to be lost when it is melted at body temperature, affecting the curative effect, polluting clothes, and causing discomfort to the patient, and the retention time of the suppository is too long (6 —8 hours) and absorb the moisture in the vagina, which is highly irritating, burying hidden dangers for recurrence, and easily destroying the acid-base balance; the ointment is delivered with a special device, which is easy to be administered unevenly, and the ointment is also easy to lose, so that the lesion cannot be obtained. Therapeutic amount of medicine is also easy to contaminate clothes; the bioavailability of effervescent tablets is reduced when the disintegration is not complete, and the above dosage forms need to be operated by hand, which is not hygienic and easy to cross-contaminate. patient discomfort

[0004] Existing various dosage form preparations all do not well solve above-mentioned problem, therefore need to provide a kind of medicaments for the treatment of vaginitis that can be convenient for patients to use, can effectively improve therapeutic effect at the same time

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