Application of derivative of pyridine carboxamide in preparation of anti-tumor medicaments

Abstract

The invention belongs to the field of genetic engineering and chemistry, and relates to the application of a derivative of pyridine carboxamide in the preparation of anti-tumor medicaments. The invention provides the application of a small-molecular compound N2,N5-di[2-(3,4-dimethoxyphenyl)ethyl]-2,5-pyridine carboxamide in the preparation of the anti-tumor medicaments. The compound can remarkably suppress the multiplication of tumor cells. The medicaments prepared from the compound for a cellular target CYPJ are difficult for patients to form medicament resistance, and have evident effect onthe tumor cells of high-expression CYPJ proteins. Therefore, the small-molecular compound of the invention is developed as a novel anti-tumor medicament, has evident tumor suppression effect and highspecificity, and provides a novel way and means for the treatment and cure of tumors.

Description

technical field

[0001] The invention relates to the fields of chemical engineering and medicine, and relates to the application of a pyridinecarboxamide derivative in the preparation of antitumor drugs. Specifically related to N 2 , N 5 -Application of bis[2-(3,4-dimethoxyphenyl)ethyl]-2,5-pyridinecarboxamide in the preparation of antitumor drugs. Background technique

[0002] Cycliphilins (CyPs) are ubiquitously distributed intracellular proteins that are highly conserved in plants, bacteria, and mammals. They were originally discovered as cellular receptors for cyclosporin A. Cyclosporin A (Cyclosporin A, CsA) is a cyclic polypeptide containing 11 amino acids isolated from fungal metabolites. It is an immunosuppressant for organ transplantation and autoimmune diseases, and has been widely used clinically. , with annual sales of more than 5 billion US dollars. Since CsA has shown various toxic and side effects since it was used in clinical practice, people pay more and ...

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