Compound of platinum compound and sodium hyaluronate and application thereof

A technology of sodium hyaluronate and compound, which can be applied in the directions of drug combination, medical preparation containing active ingredients, organic active ingredients, etc., can solve the problems of large toxic and side effects of platinum compounds, and achieve good tumor suppressing effect and good safety. Effect

Inactive Publication Date: 2019-03-26
JIANGSU TARGET BIOMEDICINE RES INST +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem of large toxic and side effects of platinum compounds in the existing anti-tumor drugs, the object of the present invention is to provide a composition of platinum derivative compounds and sodium hyaluronate, and apply it to the preparation of anti-tumor drugs

Method used

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  • Compound of platinum compound and sodium hyaluronate and application thereof
  • Compound of platinum compound and sodium hyaluronate and application thereof
  • Compound of platinum compound and sodium hyaluronate and application thereof

Examples

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Embodiment 1

[0019] Cell lines and culture: 2 liver cancer cell lines (BEL-7402, Hep-G2), 5 pancreatic cancer cell lines (BxPC-3, Capan-1, Colo357, Miapaca-2, Panc-1), 6 lung cancer cell lines (A427 , A549, NCI-H1299, NCI-H2170, NCI-H358, NCI-H460), 3 colorectal cancer cell lines (Colo205, Lovo, RKO), 6 breast cancer cell lines (HCC-1806, MCF-7, MDA- MB-231, MDA-MB-361, MDA-MB-436, TD-47), a cervical cancer cell line (Hela), these cells were donated by Nanjing University, with DMEM / RPMI1640 / McCoy containing 10% fetal bovine serum '5a medium, at 37°C, 5% CO 2 Cultivate in an incubator, change the medium every 2-3 days, and take the cells in the logarithmic growth phase for the experiment.

[0020] Cell proliferation detection (MTT method): Take cancer cells in the logarithmic growth phase to make 2×10 4 cells / mL suspension, 100 μL per well was added to a 96-well culture plate. A reagent control group, a tumor cell control group and an experimental group of various concentrations of drugs...

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Abstract

The invention relates to the fields of organic synthesis and medicine chemistry, in particular to a compound of a platinum derivative and sodium hyaluronate and application thereof. The platinum derivative and the sodium hyaluronate are subjected to combined administration, and can be applied for preparing an anti-neoplastic medicine, pharmacology experiments show that the anti-neoplastic medicinehas obvious anti-neoplastic effects on different cancer cells, specifically, the platinum derivative and sodium hyaluronate combined compound has the obvious anti-neoplastic effects, the anti-neoplastic effects are relative to the kind of the platinum derivative, and combination of the two medicines is in a dosage range; the medicine combined compound can effectively relieve toxic and side effects which are brought by individual administration of the platinum derivative; the medicine combined compound has potential development values for the novel efficient anti-tolerance anti-neoplastic medicine with low toxic and side effects.

Description

technical field [0001] The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to a composition, a preparation method and an application thereof. Background technique [0002] Cancer is a common and frequently-occurring disease that seriously endangers human health. Overcoming cancer cells has always been a hot topic in research at home and abroad. Chemotherapy is a main anti-cancer method for systemic treatment, but while it fights tumor cells, it also damages other cells. Therefore, it is imminent to seek a low-toxicity and high-efficiency anti-tumor drug for anti-tumor treatment. [0003] Platinum antineoplastic compounds have become an indispensable and most widely used drug in cancer chemotherapy. Since cisplatin, as the first generation of antineoplastic drug, was approved for marketing by the Food and Drug Administration (FDA) of the United States in 1978, platinum antineoplastic drugs began to enter people's field of vision a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/555A61K31/728A61P35/00
CPCA61K31/555A61K31/728A61P35/00A61K2300/00
Inventor 华子春穆飞飞
Owner JIANGSU TARGET BIOMEDICINE RES INST
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