Preparation and application of double-ligand modified liver cancer targeting liposome
A technology targeting liposomes and dual ligands is applied in the directions of liposome delivery, medical preparations without active ingredients, and medical preparations containing active ingredients. Cells and other problems, to achieve the effect of reducing drug side effects, improving curative effect, and good tumor inhibition effect
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[0032] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention.
[0033] refer to Figure 1-7 , screening of DSPE-PEG1000-TAT dosage in SP94 / TAT-DOX-LP;
[0034] The density of TAT modified on the surface of liposomes has a great influence on the cell-entry ability of the macromolecule carrier mediated. By exploring the effects of different TAT densities on the ratio of liposome cell uptake capacity and DOX encapsulation efficiency, we screened out Optimum TAT dosage;
[0035] Other material content in the fixed liposome, wherein the content of DSPE-PEG3400-SP94 is 0%, the amount of regulating DSPE-PEG1000-TAT accounts for 0.5%, 0.75%, 1%, 1.25% of the mol ratio of soybean lecithin (SPC) %, 1.5%, (burst) to prepare liposomes. An...
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