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Anti-cholangiocarcinoma medicine composition and application thereof

A composition and a technique for cholangiocarcinoma, which are applied in the field of pharmaceutical compositions against cholangiocarcinoma, and can solve the problems of lack of 2-lactamaminobenzoic acid and the like

Active Publication Date: 2015-03-25
滨州医学院附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no literature report on the use of 2-lactylaminobenzoic acid for anti-tumor, and there is no literature report on the anti-cholangiocarcinoma after it is used in combination with other anticancer drugs

Method used

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  • Anti-cholangiocarcinoma medicine composition and application thereof
  • Anti-cholangiocarcinoma medicine composition and application thereof
  • Anti-cholangiocarcinoma medicine composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 dispersible tablet

[0024]

[0025] Preparation process: Weigh capecitabine and 2-lactaminobenzoic acid according to the prescription, use microcrystalline cellulose as filler, cross-linked carmellose sodium as disintegrant, 5% PVP 60% ethanol solution It is used as binder, and micronized silica gel is used as flow aid. It is granulated in one step in a fluidized bed, and then compressed into tablets.

Embodiment 2

[0026] The preparation of embodiment 2 granules

[0027]

[0028] Preparation process: Weigh the prescribed amount of capecitabine, 2-lactaminobenzoic acid, starch, dextrin, and sucrose powder and mix evenly. In addition, an appropriate amount of 80% ethanol is added to the mixed powder, mixed evenly, made into a soft material, passed through a 18-mesh nylon sieve to make wet granules, dried at about 60°C, sized with a 20-mesh sieve, and packaged separately to obtain.

Embodiment 3

[0029] The preparation of embodiment 3 tablet

[0030]

[0031] Preparation process: first put capecitabine and β-cyclodextrin into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, compressible starch and mix evenly, finally add 2-lactamidobenzoic acid and mix evenly , granulated with 5% PVP in absolute ethanol as a binder, dried at 40°C, granulated, mixed with micro-silica gel, pressed into tablets, and obtained.

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PUM

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Abstract

The invention discloses an anti-cholangiocarcinoma medicine composition and an application thereof. The medicine composition comprises active components and pharmaceutically acceptable auxiliary materials, wherein the active components comprise capecitabine and 2-lactoyl aminobenzoic acid. By virtue of tests, according to the anti-cholangiocarcinoma medicine composition disclosed by the invention, the effects of cooperatively enhancing the anti-cancer cell proliferation can be achieved by combining 2-lactoyl aminobenzoic acid and capecitabine, so that the treatment purpose of resisting cholangiocarcinoma can be achieved more beneficially.

Description

technical field [0001] The invention relates to an antitumor drug, in particular to an anti-cholangiocarcinoma pharmaceutical composition and its application, and belongs to the technical field of medicine. Background technique [0002] Cholangiocarcinoma refers to malignant tumors of the extrahepatic bile duct that originate from the confluence of the left and right hepatic ducts to the lower end of the common bile duct. Clodorch sinensis infection, choledochal cyst, etc., these factors can increase the risk of cholangiocarcinoma. The main clinical manifestations are progressive jaundice accompanied by epigastric discomfort, loss of appetite, weight loss, and itching. Such as tumor ulceration and bleeding, there may be melena or positive fecal occult blood test, anemia and other manifestations. [0003] The malignant degree of cholangiocarcinoma is extremely high, and the incidence rate in Europe and the United States is very low, but the incidence rate in Southeast Asia ...

Claims

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Application Information

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IPC IPC(8): A61K31/7068A61P35/00A61K31/196
CPCA61K9/0053A61K9/10A61K9/146A61K9/2059A61K31/196A61K31/7068A61K2300/00
Inventor 林绪涛任莉张长习
Owner 滨州医学院附属医院
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