Chitosan/carboxymethyl chitosan rapid hemostatic sponge and preparation method thereof

Abstract

A chitosan / carboxymethyl chitosan rapid hemostatic sponge and a preparation method thereof belong to the biomedical material field. The invention solves the following problems: the pure chitosan hemostatic materials have poor toughness and do not have remarkable hemostasis effect; the hemostatic materials clinically commonly used at present have long hemostasis time and limited hemostasis capability toward the wounds with large amount of bleeding during use. The hemostatic material of the invention is prepared from chitosan, carboxymethyl chitosan and glycerin or from chitosan, carboxymethyl chitosan, glycerin and medicines by the process of freeze drying in a vacuum freeze dryer. The hemostatic material of the invention has good toughness, can be bent and folded at will, has short hemostasis time, can be used for treating the wounds with larger amount of bleeding, achieves rapider hemostasis effect in clinical application and can be used for hemostasis in clinical surgeries and promoting wound healing. The method is simple and convenient to operate.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a chitosan / carboxymethyl chitosan rapid hemostatic sponge and a preparation method thereof. Background technique [0002] On the battlefield, in natural disasters and in various daily emergencies, uncontrollable bleeding is the main cause of death of the wounded. Early control of bleeding becomes the best strategy to reduce patient casualties. Chitosan has the characteristics of good biocompatibility, biodegradability, hemostasis and promotion of wound healing, so chitosan-based hemostatic materials are becoming a research hotspot at home and abroad. Currently, pure chitosan hemostatic materials have the problems of poor toughness and insignificant hemostatic effect. This can be combined with other materials or drugs to improve toughness and shorten hemostasis time, as reported by Guan Jing et al. The hemostatic time of chitosan and alginate calcium salt composi...

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the poor toughness and insignificant hemostatic effect of simple chitosan hemostatic materials; while the existing clinical commonly used hemostatic materials have a long hemostatic time in use and limited hemostatic ability for large wounds with bleeding volume, etc. Problem; And provided chitosan / carboxymethyl chitosan fast hemostatic sponge and preparation method thereof

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