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Application of 2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside to preparing medicaments for treating depression

A technology of tetrahydroxystilbene and glucoside, applied in the field of medicine, can solve the problems of high price, toxic and side effects, etc.

Inactive Publication Date: 2012-05-23
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing antidepressants are mainly: tricyclics (TCAs), selective 5-HT reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), all of which have different degrees of toxic and side effects and are expensive. Therefore, it is of great theoretical and practical significance to develop new antidepressants from traditional Chinese medicine.

Method used

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Embodiment Construction

[0007] The present invention will be further described below in conjunction with embodiment.

[0008] The following animal experiment is a further detailed description of the present invention, but does not imply any limitation to the present invention. Obviously, the broadness of the pharmacological feasibility of the selected experimental animals expresses the animal groups to which the application of the present invention should be traced.

[0009] Experimental animals: Male Kunming mice, weighing 18g-30g at the beginning of the experiment, purchased from the Sichuan Medical Experimental Animal Center, SCXK[Sichuan] 2008-14, received 12h light / 12h dark every day, and the light cycle was 8:00-20: 00, the laboratory temperature is 20±2°C, and the humidity is 60%. Animals can ingest standard feed and clean water by themselves. Animal experiments comply with international experimental animal ethics requirements.

[0010] drug:

[0011] 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-gl...

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Abstract

The invention discloses application of 2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside to preparing medicaments for treating depression, in particular to application of 2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside as an active ingredient to preparing medicaments for treating depression. The invention provides the application of the 2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside as the medicaments for treating depression, and the 2,3,5,4-tetrahydroxystilbene-2-O-beta-D-glucoside is hardly innoxious and is applied to preparing medicaments for preventing or treating various depression symptoms including endogenous depression, reactive depression, masked depression, secondary depression caused by medicaments, menopausal or post-natal depression, depression induced by traumatic braininjury or brain death and depressive neurosis and medicaments for treating diabetes and depression complications and related diseases.

Description

technical field [0001] The invention belongs to medicine, especially the new application of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside extracted from natural plants, and specifically relates to their preparation and treatment Application in Depression Products. Background technique [0002] 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside is a stilbene compound with the molecular formula C 20 h 22 o 9 . The stilbene glycosides in Polygonum multiflorum has become the specific index of Polygonum multiflorum at present. In recent years, research on the biological activity, extraction process, and analysis and detection methods of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside in Polygonum multiflorum has become increasingly in-depth. Studies have found that 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside has many pharmacological effects such as: strong antioxidant scavenging free radical ability; ability to inhibit protein kinase C function, thus inhibiting tumor gr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7032A61P25/24A61P25/28
Inventor 吴晓青童妍陈晓珍马超英耿耘
Owner SOUTHWEST JIAOTONG UNIV
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