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Application of MCC950 or derivative thereof in preparation of drug for preventing or treating cognitive disorder caused by radiation

A technology for cognitive impairment, derivatives, applied in the field of medicine

Active Publication Date: 2019-03-08
NANHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, whether the NLRP3 inflammasome inhibitor MCC950 can be used as a drug to improve radiation-induced cognitive impairment has not been reported yet.

Method used

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  • Application of MCC950 or derivative thereof in preparation of drug for preventing or treating cognitive disorder caused by radiation
  • Application of MCC950 or derivative thereof in preparation of drug for preventing or treating cognitive disorder caused by radiation

Examples

Experimental program
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Effect test

Embodiment 1

[0029] In this example, novel object discrimination test and novel position discrimination test were used to investigate the effect of NLRP3 inflammasome inhibitor MCC950 on the learning and memory behavior of irradiated mice.

[0030] Animals: 36 female Kunming mice, 3 months old, weighing about 25g. Animals were kept at room temperature (22±2)°C, humidity (45%-65%) and light and dark (12h:12h) environment, free to eat and drink.

[0031] Animal grouping and handling:

[0032] (1) Normal control group (Control, n=12): mice were given 0Gy absorbed dose under the same radiation environment;

[0033] (2) Radiation-induced cognitive impairment group (IR, n=12): Mice received 137Cs-γ-ray whole-body radiation to an absorbed dose of 4Gy to induce radiation-induced cognitive impairment, and the dose rate was 1.118Gy / min;

[0034] (3) MCC950 intervention group (IR+MCC950, n=12): Mice were given 137Cs-γ-ray whole-body radiation to an absorbed dose of 4Gy. At the same time, they were ...

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Abstract

The invention provides the application of MCC950 or a derivative thereof in preparation of a drug for preventing or treating a cognitive disorder caused by radiation. Research results of the inventionare as follows: the learning memory of a radiated mouse is decreased significantly, and the learning memory ability of the mouse is significantly improved after the mouse is treated with the MCC950,which indicates that an NLRP3inflammasome inhibitor MCC950 can prevent the cognitive disorder caused by the radiation indeed. The NLRP3inflammasome inhibitor MCC950 has a very good preventive and protective effect on clinical medicine, particularly the radiology department, and nuclear accidents and the like, and is particularly suitable for radiotherapy patients to prevent and treat the cognitivedisorder, such as the memory loss and learning ability reduction, caused by the radiation; and the application has an extremely large popularization value.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of MCC950 or its derivatives in the preparation of drugs for preventing or treating cognitive impairment caused by radiation. Background technique [0002] With the wide application of nuclear energy and radiation energy in various fields such as diagnosis and treatment of diseases, nuclear power generation and heating, scientific research, and military affairs, people have more and more opportunities to be exposed to ionizing radiation, and more and more people pay attention to the damage to the body caused by ionizing radiation and its prevention and treatment. . Ionizing radiation can accelerate the aging process and induce neuron degeneration. Among them, radiation cognitive dysfunction is a common radiation brain injury after clinical radiation therapy or accidental exposure to ionizing radiation. Its clinical manifestations are mainly spatial memory and ver...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/341A61P25/28
CPCA61K31/341A61P25/28
Inventor 万炜曹文宇王贞徐杨何洁牛磊杨惠罗诗诗罗丹钟小林刘政海陈熙曾佳玉
Owner NANHUA UNIV
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