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Medicinal composition and preparation method thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of increasing adverse reactions such as skin allergies, papules, heart palpitations, shortness of breath, influence of blood and hematopoietic system, and unclear interaction, etc., so as to improve the activity of endogenous antioxidant enzymes , reduce MDA content, improve the effect of immune function

Active Publication Date: 2015-01-14
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] 2. Effects on blood and hematopoietic system
The patent also describes the preparation method of the composition. This invention adopts the method of separating and purifying the components first, and then mixing them. This not only discards many active ingredients, but also makes the preparation cost quite high
[0025] In addition, the total saponins of Panax notoginseng in the prior art contain 5 quantifiable components, with a total content of 65% to 80%, and a considerable proportion of unknown impurities. Many problems have been brought about in quality control and application, which increases the probability of adverse reactions such as skin allergies, chills, papules, palpitations, shortness of breath, etc.

Method used

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  • Medicinal composition and preparation method thereof

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Embodiment 1

[0060] Embodiment 1, preparation pharmaceutical composition of the present invention

[0061] Weigh 10 kg of Panax notoginseng, infiltrate with 60-85% ethanol with a weight ratio of 1 times, soak softly, grind it into a coarse powder by wet method, add 70% ethanol with 5, 6, and 6 times the weight of dry medicinal materials, and reflux extraction 3 times, 1 hour each time, collect the extract and filter. Take the filtrate to recover ethanol until there is no alcohol smell, add water to make a solution containing 0.5g of crude drug per 1ml, put it on a macroporous adsorption resin column, elute with water and 70% ethanol respectively, concentrate the ethanol eluate, and then put it on a macroporous ion exchange Resin column, eluted with 70% ethanol, collected ethanol eluted part, concentrated under reduced pressure, concentrated eluent, put on aluminum oxide column, eluted with 85% ethanol, concentrated eluent. Recrystallize and refine with acetone, and dry to obtain the pharm...

Embodiment 2

[0074] Embodiment 2 prepares pharmaceutical composition of the present invention

[0075] Weigh 10 kg of Panax notoginseng, infiltrate with 60-85% ethanol with a weight ratio of 1 times, soak softly, wet grind into a coarse powder, add 80% ethanol with an amount of 8, 10, and 10 times the weight of the medicinal material, and reflux extraction 3 times, 1 hour each time, collect the extract and filter. Take the filtrate to recover ethanol until there is no alcohol smell, add water to make a solution containing 0.5g crude drug per 1ml, put it on a macroporous adsorption resin column, elute with water and 75% ethanol respectively, concentrate the alcohol eluate, and then put it on a macroporous ion exchange Resin column, eluted with 75% ethanol, collected ethanol eluted part, concentrated under reduced pressure, concentrated eluent, put on aluminum oxide column, eluted with 80% ethanol, concentrated eluent. Recrystallize and refine with acetone, and dry to obtain the pharmaceuti...

Embodiment 3

[0078] Embodiment 3 prepares pharmaceutical composition of the present invention

[0079] Weigh 10 kg of Panax notoginseng, infiltrate with 1 times the weight of 85% ethanol, soak it softly, wet grind it into a coarse powder, add 85% ethanol whose weight is 13 times the weight of the dry medicinal material each time, and reflux extraction 4 times, Each time for 2 hours, the extract was collected and filtered. Take the filtrate to recover ethanol until there is no alcohol smell, add water to make a solution containing 0.5g of crude drug per 1ml, put it on a macroporous adsorption resin column, elute with water and 80% ethanol respectively, concentrate the alcohol eluate, and then put it on a macroporous ion exchange Resin column, eluted with 80% ethanol, collected ethanol eluted part, concentrated under reduced pressure, concentrated eluent, put on aluminum oxide column, eluted with 80% ethanol, concentrated eluent. Recrystallize and refine with acetone, and dry to obtain the ...

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Abstract

The invention provides a medicinal composition, which comprises the following components: ginsenoside Rb1, ginsenoside Rg1, notoginsenoside R1, ginsenoside Rd, ginsenoside Re, ginsenoside Rf, ginsenoside Rc, ginsenoside Rh1, ginsenoside Rb2 and ginsenoside Rg3. The invention also provides a preparation method for the medicinal composition. The medicinal composition has definite components; compared with the total notoginsenoside in the prior art, the medicinal composition has stable quality and good controllability; and results of experiments of acute toxicity, undue toxicity, hemolysis and the like show that the medicinal composition has higher safety and wide clinical application prospect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition and a preparation method thereof. Background technique [0002] Panax notoginseng, ginseng and American ginseng belong to the genus Araliaceae, and all three are valuable Chinese medicinal materials. Modern studies on the chemical constituents of Panax notoginseng and ginseng have shown that Panax notoginseng saponins are similar to ginsenosides, both of which are mainly dammarane-type saponins, but the total saponins content of Panax notoginseng is high, and the meaningful ginsenoside Rb1 and Rg1 was higher than that of ginseng. [0003] Saponin is one of the main active components of Panax notoginseng. In addition, it also contains notoginseng, an effective hemostatic component, as well as polysaccharides, amino acids, volatile oils, flavonoids and trace elements. The monomeric saponins extracted and separated from Panax notoginseng include ginsenosides Rb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K33/14A61K31/195A61P9/10A61P9/12A61P3/06A61P7/02
Inventor 张国丽王子幼杨兆祥
Owner KPC PHARM INC
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