Traditional Chinese medicine composite with effects of reducing heat, relieving ache and resisting virus and preparation method thereof

A technology of composition and traditional Chinese medicine preparation, which is applied in antiviral agents, drug combinations, medical preparations containing active ingredients, etc., and can solve problems such as teratogenicity and high toxicity

Active Publication Date: 2014-07-02
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In recent years, although some progress has been made in antiviral drug research, there are still limited effective and safe antiviral drugs. For example, although ribavirin, a broad-spectrum antiviral agent, can shorten the course of influenza A and B, However, due to its high toxicity and the possibility of teratogenicity, it has not been approved for the prevention and treatment of viruses.

Method used

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  • Traditional Chinese medicine composite with effects of reducing heat, relieving ache and resisting virus and preparation method thereof
  • Traditional Chinese medicine composite with effects of reducing heat, relieving ache and resisting virus and preparation method thereof
  • Traditional Chinese medicine composite with effects of reducing heat, relieving ache and resisting virus and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0159] Example 1: Capsules

[0160] Prescription: Sophora 900g, Gardenia 900g, Gentian 900g

[0161] Preparation method: take Sophora flavescens, gardenia, gentian, add 15 times the amount of 0.3% hydrochloric acid aqueous solution, decoct twice, 2 hours each time, filter, and concentrate the filtrate under reduced pressure to an extract with a relative density of 1.05-1.10, Add ethanol to the alcohol content of 70%, stand for 36 hours, filter, concentrate the filtrate under reduced pressure to an extract with a relative density of 1.05 to 1.10, extract with n-butanol, collect the extract, and recover the extract to no n-butanol , dry, pulverize, mix well, add appropriate amount of starch or dextrin, dry, pulverize, sieve, put into capsules, and make 1000 capsules.

[0162] Functions and indications: clearing away heat and detoxifying, clearing away damp-heat. It is used to treat high fever, mild aversion to wind-cold, headache and body pain, cough, and yellow phlegm caused ...

Embodiment 2

[0164] Example 2: Capsules

[0165] Prescription: Sophora flavescens 500g, Gardenia 700g, Gentian 400g

[0166] Preparation method: take Sophora flavescens, gardenia, gentian, add 12 times the amount of 0.3% hydrochloric acid aqueous solution, decoct twice, 3 hours each time, filter, concentrate the filtrate under reduced pressure to extract, add ethanol to the alcohol content of 70 %, left standing for 24 hours, filtered, the filtrate was concentrated under reduced pressure to extract, extracted with n-butanol, the extract was collected, the extract was recovered to be free of n-butanol, dried, pulverized, and the dry powder was added with an appropriate amount of auxiliary materials (such as two Silica, dextrin, starch, phosphate, carbonate, mannitol, sorbitol, sorbic acid or potassium salt, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannose One or more of the diluting auxiliary materials such as sugar alcohol), dried, pulverized, sieve...

Embodiment 3

[0169] Example 3: Capsules

[0170] Prescription: Sophora 900g, Gardenia 900g, Gentian 600g

[0171]Preparation method: take Sophora flavescens, gardenia and gentian, add 20 times the amount of 0.2% hydrochloric acid aqueous solution, decoct once for 3 hours, filter, and concentrate the filtrate under reduced pressure to an extract with a relative density of 1.05-1.10, add ethanol To the alcohol content of 75%, stand for 36 hours, filter, concentrate the filtrate under reduced pressure to an extract with a relative density of 1.05-1.10, extract with n-butanol, collect the extract, recover the extract to no n-butanol, dry , pulverize, add appropriate amount of excipients (such as silicon dioxide, dextrin, starch, phosphate, carbonate, mannitol, sorbitol, sorbic acid or potassium salt, xylitol, maltose, glucose, fructose, right One or more of the diluting auxiliary materials such as glycoside, glycine, starch, sucrose, lactose, mannitol, etc.), dried, pulverized, sieved, put in...

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Abstract

The invention relates to a traditional Chinese medicine composite, in particular to a traditional Chinese medicine composite with the effects of reducing heat, relieving ache and resisting virus and the preparation method thereof. The composite is prepared from 3 to 9 weight parts of lightyellow sophora root, 6 to 9 weight parts of gardenia and 3 to 9 weight parts of Chinese gentian. The traditional Chinese medicine composite can be prepared into tablets, capsules, pills, grains, soft capsules, injection or oral liquid by adopting the conventional medicine preparation method in pharmacy. The experiment research indicates that the traditional Chinese medicine composite has the advantages of obvious treatment effect, high safety and wide application prospect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicinal composition with antipyretic, analgesic and antiviral effects and a preparation method thereof. technical background [0002] Viruses are the smallest biological pathogens, and many diseases are caused by viral infections. A virus can cause a variety of diseases, and a disease can also be caused by a variety of viruses. The virus can cause different diseases depending on the conditions of the infected body. For example, the measles virus generally causes measles, but it can cause severe disease in immunocompromised people. Cellular pneumonia; can cause subacute sclerosing whole brains after persistent infection of the nervous system. Another example is the influenza virus that can cause colds in ordinary people, and can cause myocarditis and life-threatening diseases in immunocompromised people. The research and development of antivir...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61P29/00A61P31/12
Inventor 萧伟王振中刘涛郑伟然韩兆忠章晨峰陈凤龙
Owner JIANGSU KANION PHARMA CO LTD
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