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Traditional Chinese medicine composite with effects of reducing heat, relieving ache and resisting virus and preparation method thereof

A technology of composition and traditional Chinese medicine preparation, which is applied in antiviral agents, drug combinations, medical preparations containing active ingredients, etc., and can solve problems such as teratogenicity and high toxicity

Active Publication Date: 2011-04-27
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In recent years, although some progress has been made in antiviral drug research, there are still limited effective and safe antiviral drugs. For example, although ribavirin, a broad-spectrum antiviral agent, can shorten the course of influenza A and B, However, due to its high toxicity and the possibility of teratogenicity, it has not been approved for the prevention and treatment of viruses.

Method used

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  • Traditional Chinese medicine composite with effects of reducing heat, relieving ache and resisting virus and preparation method thereof
  • Traditional Chinese medicine composite with effects of reducing heat, relieving ache and resisting virus and preparation method thereof
  • Traditional Chinese medicine composite with effects of reducing heat, relieving ache and resisting virus and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0159] Embodiment 1: Capsules

[0160] Prescription: Sophora 900g, Gardenia 900g, Gentian 900g

[0161] Preparation method: take Sophora flavescens, gardenia and gentian, add 15 times the amount of 0.3% hydrochloric acid aqueous solution, decoct twice for 2 hours each time, filter, and concentrate the filtrate under reduced pressure to an extract with a relative density of 1.05-1.10. Add ethanol until the alcohol content is 70%, let it stand for 36 hours, filter, and concentrate the filtrate under reduced pressure to an extract with a relative density of 1.05 to 1.10, extract with n-butanol, collect the extract, and recover the extract until there is no n-butanol , dried, pulverized, mixed evenly, added appropriate amount of starch or dextrin, dried, pulverized, sieved, packed into capsules, and made into 1000 capsules.

[0162] Function cures mainly: heat-clearing and toxic substances removing, dredging damp-heat. It is used to treat high fever, slight aversion to wind and ...

Embodiment 2

[0164] Embodiment 2: capsules

[0165] Prescription: Sophora flavescens 500g, gardenia 700g, gentian 400g

[0166] Preparation method: take Sophora flavescens, gardenia and gentian, add 12 times the amount of 0.3% hydrochloric acid aqueous solution, decoct twice for 3 hours each time, filter, concentrate the filtrate under reduced pressure to extract, add ethanol until the alcohol content is 70 %, stand still for 24 hours, filter, the filtrate is concentrated under reduced pressure to the extract, extract with n-butanol, collect the extract, and the extract is recovered to no n-butanol, dried, pulverized, and an appropriate amount of auxiliary materials (such as two Silicon oxide, dextrin, starch, phosphate, carbonate, mannitol, sorbitol, sorbic acid or potassium salt, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannose one or more of diluting auxiliary materials such as sugar alcohol), dried, pulverized, sieved, packed into capsules, and ...

Embodiment 3

[0169] Embodiment 3: capsules

[0170] Prescription: flavescens 900g, gardenia 900g, gentian 600g

[0171]Preparation method: take Sophora flavescens, gardenia and gentian, add 20 times the amount of 0.2% hydrochloric acid aqueous solution, decoct once for 3 hours, filter, concentrate the filtrate under reduced pressure to an extract with a relative density of 1.05-1.10, add ethanol When the alcohol content is 75%, let stand for 36 hours, filter, and concentrate the filtrate under reduced pressure to extract with a relative density of 1.05 to 1.10, extract with n-butanol, collect the extract, recover the extract until there is no n-butanol, and dry , pulverized, adding appropriate amount of excipients (such as silicon dioxide, dextrin, starch, phosphate, carbonate, mannitol, sorbitol, sorbic acid or potassium salt, xylitol, maltose, glucose, fructose, dextrose, etc. One or more of diluting excipients such as glucoside, glycine, starch, sucrose, lactose, mannitol, etc.), dried...

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Abstract

The invention relates to a traditional Chinese medicine composite, in particular to a traditional Chinese medicine composite with the effects of reducing heat, relieving ache and resisting virus and the preparation method thereof. The composite is prepared from 3 to 9 weight parts of lightyellow sophora root, 6 to 9 weight parts of gardenia and 3 to 9 weight parts of Chinese gentian. The traditional Chinese medicine composite can be prepared into tablets, capsules, pills, grains, soft capsules, injection or oral liquid by adopting the conventional medicine preparation method in pharmacy. The experiment research indicates that the traditional Chinese medicine composite has the advantages of obvious treatment effect, high safety and wide application prospect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition with antipyretic, analgesic and antiviral effects and a preparation method thereof. technical background [0002] Viruses are the smallest biological pathogens, and many diseases are caused by viral infections. One virus can cause many kinds of diseases, and one disease can also be caused by many kinds of viruses. The virus can cause different diseases according to the conditions of the infected organism. Cellular pneumonia; can cause subacute cirrhosis pancerebral after persistent infection of the nervous system. Another example is that influenza virus can cause a cold on common people, and can cause myocarditis and be life-threatening on immunocompromised persons. The research and development of antiviral drugs has become the focus of drug research. [0003] Since the development of antiviral drugs started relatively lat...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P29/00A61P31/12
Inventor 萧伟王振中刘涛郑伟然韩兆忠章晨峰陈凤龙
Owner JIANGSU KANION PHARMA CO LTD
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