Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

htsnp for determining the genotype of the ugt1a gene and its method for multiplex genotyping

A gene and genome technology, applied in the field of htSNP used to determine the genotype of UGT1A gene and its use in multiple genotyping, can solve the problems of insufficient research

Inactive Publication Date: 2011-12-14
申载国
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are not many studies on genetic variants in the genes of Koreans, their corresponding haplotypes, and htSNP selection according to each haplotype

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • htsnp for determining the genotype of the ugt1a gene and its method for multiplex genotyping
  • htsnp for determining the genotype of the ugt1a gene and its method for multiplex genotyping
  • htsnp for determining the genotype of the ugt1a gene and its method for multiplex genotyping

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0099] Exemplary embodiments of the present invention will be described below with reference to the accompanying drawings, in which like reference numerals denote like elements, and repetitive description will be avoided as much as possible.

[0100] The present invention can be used to determine the genotype of the CYP1A2 gene found in the Korean people through the variant analysis of the Korean CYP1A2 gene, select htSNP as the optimal signature set for each haplotype, and confirm its availability. In addition, the present invention allows for the determination of novel haplotypes of the human CYP1A2 gene.

[0101] The method for selecting the htSNP of the human CYP1A2 gene of the present invention is as follows:

[0102] (a) collecting a biological sample from a subject;

[0103] (b) extract nucleic acid from the sample collected in operation (a);

[0104] (c) performing PCR with primers that use the nucleic acid extracted in operation (b) as a template to amplify the huma...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to htSNPs for determining a genotype of cytochrome P450 1A2 (CYP1A2), 2A6 (CYP2A6) and 2D6 (CYP2D6), PXR and UDP-glucuronosyltransferase Ia (UGT1A) genes and a gene chip using the same, and more particularly, to a selection method of htSNPs for determining a haplotype of human CYP1A2, CYP2A6, CYP2D6, PXR and UGT1A genes, a method of determining a genotype of the genes by using the htSNPs and a gene chip therefor.

Description

[0001] This application is a divisional application, the international application number of the original application is PCT / KR2007 / 003102, the Chinese national application number is 200780033677.3, the application date is June 26, 2007, and the invention title is "for determining cytochrome P450 1A2, Haplotype-signature single nucleotide polymorphisms of the genotypes of the 2A6 and 2D6, PXR, and UDP-glucuronosyltransferase 1A genes and their use in multiplex genotyping". technical field [0002] The apparatus and method of the present invention relate to haplotype signature single nucleotide polymorphisms (htSNPs) and Gene chip, more specifically, relates to a selection method of htSNP for determining the haplotypes of human CYP1A2, CYP2A6, CYP2D6, NR1I2 (=PXR) and UGT1A genes, a method of determining the genotype of the genes and a method for determining the genotype of the genes The gene chip of the method described above. Background technique [0003] Because of geneti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6869C12Q1/6827C12Q2537/165
Inventor 申载国张仁珍李相燮郑惠恩车仁浚金佑永芮晟洙金垠泳车恩暎孙知弘崔银贞金江美郑玄朱
Owner 申载国
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com