Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of pharmaceutical adjuvant sodium carboxymethyl starch

A technology of sodium carboxymethyl starch and pharmaceutical excipients, which is applied in the field of preparation of sodium carboxymethyl starch as a pharmaceutical excipient, and can solve the problems of increasing the production cost of sodium carboxymethyl starch, complicated process, and cumbersome preparation methods, etc.

Inactive Publication Date: 2012-01-11
BENGBU COLLEGE
View PDF2 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The preparation method of existing sodium carboxymethyl starch is more loaded down with trivial details mostly, and technique is complicated, has strengthened the manufacture cost of sodium carboxymethyl starch

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation method of pharmaceutical auxiliary material sodium carboxymethyl starch comprises the following steps:

[0032] The first step: Inject 300 parts of ethanol with a concentration of 83% (v / v) into the reactor, drop 25 parts of sodium hydroxide under stirring, continue stirring for 10 minutes after the temperature is raised to 40° C., to obtain a sodium hydroxide solution;

[0033] Step 2: Slowly put 50 parts of starch into the above-mentioned reactor while stirring, and continuously stir for 30 minutes at 40°C to carry out alkalization;

[0034] The third step: after alkalization is completed, drop into the reactor 40 parts of 83% (v / v) ethanol and 20 parts of chloroacetic acid to form a solution, react after 150min, and centrifuge to obtain sodium carboxymethyl starch;

[0035] The fourth step: transfer the sodium carboxymethyl starch obtained by centrifugation into an open container, then add 84% (v / v) ethanol, the amount of addition is based on submergi...

Embodiment 2

[0040] The preparation method of pharmaceutical auxiliary material sodium carboxymethyl starch comprises the following steps:

[0041] The first step: Inject 400 parts of ethanol with a concentration of 86% (v / v) into the reactor, drop 35 parts of sodium hydroxide under stirring, continue stirring for 10 minutes after the temperature is raised to 50° C., to obtain a sodium hydroxide solution;

[0042]Step 2: Slowly put 50 parts of starch into the above-mentioned reactor while stirring, and continuously stir for 30 minutes at 50°C to carry out alkalization;

[0043] The third step: after alkalization is completed, drop into the reactor a solution made of 50 parts of 86% (v / v) ethanol and 28 parts of chloroacetic acid to react, after reacting for 180min, centrifuge to obtain sodium carboxymethyl starch ;

[0044] The 4th step: the sodium carboxymethyl starch obtained by centrifugation is transferred to an open container, then add 86% (v / v) ethanol, the addition is based on subm...

Embodiment 3

[0049] The preparation method of pharmaceutical auxiliary material sodium carboxymethyl starch comprises the following steps:

[0050] The first step: Inject 250 parts of ethanol with a concentration of 80% (v / v) into the reactor, add 12 parts of sodium hydroxide at the same time in a stirring state, heat up to 30-50°C and continue stirring for 10 minutes to obtain hydrogen hydroxide sodium solution;

[0051] Step 2: Slowly put 50 parts of starch into the above-mentioned reactor while stirring, and continuously stir for 30 minutes at 35°C to carry out alkalization;

[0052] The third step: after alkalization is completed, put into the reactor a solution made of 30 parts of 80% (v / v) ethanol and 10 parts of chloroacetic acid to react, after reacting for 130min, centrifuge to obtain carboxymethyl starch sodium;

[0053] The fourth step: transfer the sodium carboxymethyl starch obtained by centrifugation into an open container, then add 80% (v / v) ethanol, the amount of addition...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation method of pharmaceutical adjuvant sodium carboxymethyl starch. The preparation method comprises the following chemical reactions: carrying out etherification reaction on starch and sodium hydroxide solution, after the reaction, washing and centrifugally separating so as to obtain the qualified sodium carboxymethyl starch, wherein the washing process is used for desalting. The preparation method provided by the invention has the advantages that the step is simple and reasonable, and the cost of the obtained pharmaceutical adjuvant sodium carboxymethyl starch is lower. The obtained sodium carboxymethyl starch is dried under 75 DEG C-95 DEG C so as to obtain the product with the qualified water content, and then the product is pulverized and sieved, and is introduced into a weighing and packaging process. The main component of the supernatant liquid, washing liquid and filtered solution generated in the processing step is ethanol and ethanol can be recycled by a fractionating tower.

Description

technology field. [0001] The invention relates to a preparation method of sodium carboxymethyl starch as a medical auxiliary material. Background technique [0002] The efficacy of solid oral medications depends on the rate at which the tablet or capsule disintegrates in the patient's gastrointestinal tract. As with all solid oral dosage forms, disintegrants can be added to the pharmaceutical formulation as functional fillers. These excipients help the tablet or capsule disintegrate when it comes in contact with water. [0003] Starch-based multifunctional excipients such as sodium carboxymethyl starch have properties such as binding properties, disintegration properties, and lubricity, and can be used as disintegrants for tablets and capsules. [0004] The preparation method of existing carboxymethyl starch sodium is mostly more loaded down with trivial details, and technique is complicated, has strengthened the production cost of carboxymethyl starch sodium. Contents o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08B31/12A61K47/36
Inventor 郑桂富王永斌张斌马龙
Owner BENGBU COLLEGE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com