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A set of blood vessel dilating effective ingredients from Ligusticum chuanxiong volatile oil

A technique of dilating blood vessels and compositions, which is applied in the field of research and development of new Chinese medicines, and can solve problems such as difficulty in reflecting the characteristics and laws of traditional Chinese medicine.

Inactive Publication Date: 2012-05-30
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current research and development ideas based on natural medicines, that is, the traditional Chinese medicine research and development system dominated by a single component still occupies a considerable position, and it is difficult to reflect the characteristics and laws of traditional Chinese medicine.

Method used

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  • A set of blood vessel dilating effective ingredients from Ligusticum chuanxiong volatile oil
  • A set of blood vessel dilating effective ingredients from Ligusticum chuanxiong volatile oil
  • A set of blood vessel dilating effective ingredients from Ligusticum chuanxiong volatile oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] A pharmaceutical composition, the composition and dosage of which are 1.02-2.52 parts of sabinene, 1.4-2.76 parts of gamma-terpinene, 1.27-2.58 parts of terpinolene, and 7.53-10.16 parts of (-)-4-terpineol , 1.37-2.21 parts of p-vinylguaiacol, 0.77-1.26 parts of α-celrenene, 0.61-1.43 parts of (-)-spoon eucalyptol, (+)-0.14- 0.81 parts, 1.83-4.10 parts of 4-iodoindoline, 3.19-7.66 parts of n-butenylphthalide, 1.39-2.23 parts of N-acetylphenylhydrazine, 8.23-14.34 parts of 4,5-dihydro-3-butylphthalide Parts, 39.00-51.29 parts of galactone.

[0076] Wherein, each component in the above composition can be purchased from the market or obtained by self-made chuanxiong volatile oil by gas-mass or liquid-mass chromatography.

Embodiment 2

[0078] A pharmaceutical composition, its composition and dosage are 1.02 parts of sabinene, 1.4 parts of gamma-terpinene, 1.27 parts of terpinolene, 7.53 parts of (-)-4-terpineol, p-vinylguaiacol 1.37 parts, 0.77 parts of α-celerene, 0.61 parts of (-)-cineoleol, (+)-0.14 parts of eucalyptol, 1.83 parts of 4-iodoindoline, n-butenyl 3.19 parts of phthalide, 1.39 parts of N-acetylphenylhydrazine, 8.23 ​​parts of 4,5-dihydro-3-butylphthalide, and 39.00 parts of galuslide.

[0079] Wherein, each component in the above composition can be purchased from the market or obtained by self-made chuanxiong volatile oil by gas-mass or liquid-mass chromatography.

Embodiment 3

[0081] A pharmaceutical composition, its composition and dosage are 2.52 parts of sabinene, 2.76 parts of gamma-terpinene, 2.58 parts of terpinolene, 10.16 parts of (-)-4-terpineol, p-vinylguaiacol 2.21 parts, 1.26 parts of α-celerene, 1.43 parts of (-)-cineoleol, 0.81 parts of (+)-cineol, 4.10 parts of 4-iodoindoline, n-butenyl 7.66 parts of phthalide, 2.23 parts of N-acetylphenylhydrazine, 14.34 parts of 4,5-dihydro-3-butylphthalide, and 51.29 parts of galuslide.

[0082] Wherein, each component in the above composition can be purchased from the market or obtained by self-made chuanxiong volatile oil by gas-mass or liquid-mass chromatography.

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Abstract

The invention uses Ligusticum chuanxiong volatile oil as a research object, and identifies 13 chemical components related to blood vessel activities (sabinene, gamma-terpinene, terpinolene, (-)-4-terpineol, 4-vinylguaiacol, alpha-selinene, (-)-spainulenol, (+)-spainulenol, 4-iodoindoline, n-butylidenephthalide, N-acetylphenylhydrazine, 4,5-dihydro-3-butylphthalide, and ligustilide), wherein ligustilide, 4,5-dihydro-3-butylphthalide, n-butylidenephthalide and (-)-4-terpineol are main components with blood vessel dilating effect in Ligusticum chuanxiong volatile oil. The identification method comprises the following steps: extracting volatile oil by steam distillation, analyzing chemical components of the volatile oil with GC-MS (gas chromatography-mass spectroscopy), detecting blood vessel dilating activity of the volatile oil, constructing a mathematical model between Ligusticum chuanxiong volatile oil chemical components and blood vessel dilating activity using data mining methods (LARS (least-angle regression) and LASSO (leastabsolute shrinkage and selection operator) regression algorithms), and analyzing the correlation between the components and the blood vessel dilating activity. The blood vessel dilating effective ingredients of the invention can be used for preparing blood vessel dilating medicines.

Description

technical field [0001] The invention relates to the field of research and development of new traditional Chinese medicines, in particular to the identification of active ingredients of traditional Chinese medicines. Specifically, taking the volatile oil of Rhizoma Chuanxiong as the research object, the active ingredients were screened through data mining to provide technical support for the design of traditional Chinese medicine prescriptions and the optimization of the production process. Background technique [0002] For a long time, compound prescriptions have been the main form of clinical application of traditional Chinese medicine. The composition of traditional Chinese medicine compound is determined according to the theory of traditional Chinese medicine and combined with the specific syndrome type of the patient. It has rich connotation and theoretical basis, and it is not a simple addition of single-flavored decoction pieces. However, the current research and deve...

Claims

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Application Information

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IPC IPC(8): A61K31/404A61K31/365A61K31/165A61K31/085A61K31/045A61K31/015A61P9/08
Inventor 杨洪军陈建新陈畅李洪梅唐仕欢吴宏伟许海玉李韶菁李德凤
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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