Emulsion-type liquid composition for oral cavity, and process for production thereof
A composition and emulsification type technology, applied in the directions of oral care, drug combination, cosmetic preparations, etc., can solve the problems of difficult periodontal disease, halitosis prevention effect, difficulty in satisfying the appearance stability of preparations, and difficulty in fully exerting bactericidal effect. , to achieve the effects of good appearance stability over time, good appearance stability and high retention
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[0088] Hereinafter, the present invention will be specifically described by way of experimental examples, examples, and comparative examples, but the present invention is not limited to the following examples.
[0089] In the preparation of the liquid oral composition of each example, isopropyl methylphenol (manufactured by Osaka Chemical Industry Co., Ltd.), polyoxyethylene (60) hydrogenated castor oil (manufactured by Nikko Chemical Corporation), polyoxyethylene (80) hydrogenated castor oil Sesame oil (manufactured by Nikko Chemical Corporation), emulsion (average particle size 200nm, NET-TE 50, manufactured by Nikko Chemical Corporation), glycerin (100%, manufactured by Sakamoto Pharmaceutical Co., Ltd.), propylene glycol (manufactured by Asahi Glass Corporation), polyethylene glycol Alcohol #400 (manufactured by Lion Chemical Co., Ltd.), tocopheryl acetate (manufactured by DSM New Trijapan Co., Ltd.), citric acid (manufactured by Fuso Chemical Co., Ltd.), sodium citrate (ma...
experiment example 1
[0099] Liquid oral compositions (mouthwashes) having the compositions shown in Tables 1 to 5 were prepared by a conventional method, and finally the emulsion was dispersed and evaluated as follows. The results are shown in Tables 1-5.
[0100] Appearance stability evaluation:
[0101] Fill 450mL of the liquid oral composition sample into a 450mL PET container (polyethylene terephthalate container manufactured by Yoshino Industry Co., Ltd.), and store it in a thermostat at 50°C for 3 months, or at -10°C After being stored in a thermostat for 3 months, its stability was compared with that of the reference product (initial product of Example 3), and visually judged according to the following criteria.
[0102] Evaluation criteria for appearance stability (50°C, 3 months)
[0103] ⊚: No change in color tone of the preparation was observed.
[0104] ◯: There is no problem although the preparation slightly fades.
[0105] Δ: Discoloration of the preparation occurred.
[0106] ...
experiment example 2
[0114]The periodontal disease-causing biofilm penetrating and sterilizing ability of the liquid oral compositions shown in Tables 1 to 5 was evaluated according to the following method. The results are shown in Tables 1-5.
[0115] Evaluation of biofilm penetration sterilization ability:
[0116] (1) Preparation method of model periodontal disease pathogenic biofilm
[0117] A hydroxyapatite (HA) plate (manufactured by Asahi Optical Co., Ltd.) with a diameter of 7mm x thickness of 3.5mm was treated with human non-irritating saliva filtered through a 0.45μm filter for 4 hours, and used as a carrier for the production of a model biofilm, and a culture medium A solution obtained by dissolving 30 g of TBS medium (manufactured by Difco) in 1 L of pure water and adding 5 mg of hemin (manufactured by Sigma) and 0.5 mg of vitamin K (manufactured by Sigma) was used. To make model biofilms, Streptococcus gordonii strain ATC51656 and Actinomyces naeslundii strain ATCC51655 were used as...
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