Agomelatine benzenesulfonic acid compound and preparation method thereof

A technology of agomelatine benzenesulfonic acid and compound, which is applied in the field of agomelatine benzenesulfonic acid compound and preparation thereof

Active Publication Date: 2012-10-03
SHANGHAI RIGHTHAND PHARMTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Reports on the crystal form of agomelatine are disclosed in patents such as EP0447285, CN200510071611.6, CN200610108396.7, CN200610108394.8, CN200610108395.2 and CN200910047399.2. In the report of similar complexes, only in CN201010126254.x disclosed agomelatine hydrogen chloride hydrate and its preparation method; CN201010126263.9 disclosed agomelatine hydrogen bromide hydrate and its preparation method; CN201010187158.6 Agomelatine acetic acid solvate was found, and other salts were not reported

Method used

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Embodiment 1

Embodiment 2

Embodiment 3

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Abstract

The invention relates to agomelatine benzenesulfonic acid compound of a formula I and a preparation method thereof; the agomelatine benzenesulfonic acid compound obtained by the invention is good in product stability, high in purity and is suitable for application demand when finished drug is prepared; preparation technology is also very simple; and a high-purity product can be obtained without special operation, wherein in the formula (I), R=CH3, H.

Description

technical field The invention relates to an agomelatine benzenesulfonic acid complex, a preparation method thereof, and a pharmaceutical component containing the agomelatine benzenesulfonic acid complex. Background technique Agomelatine, its English name is Agomelatine, its chemical name is N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, CAS number: [138112-76-2], molecular formula :C 15 h 17 NO 2 , molecular weight: 243.31. Structural formula: (II). Agomelatine is a melatonin agonist developed by the French Servier company, which also has the effect of antagonizing 5HT2C receptors, and its trade name is Valdoxan. It is the first melatonin antidepressant that can effectively treat depression, improve sleep parameters and maintain sexual function, with fewer sexual adverse reactions. Reports on the crystal form of agomelatine are disclosed in patents such as EP0447285, CN200510071611.6, CN200610108396.7, CN200610108394.8, CN200610108395.2 and CN200910047399.2. In the r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C309/30C07C309/29C07C303/32C07C233/18C07C231/12A61K31/185A61K31/165A61P25/20A61P25/22A61P25/18A61P25/24A61P9/00A61P1/14
Inventor 王海平池骋池正明王进许关煜
Owner SHANGHAI RIGHTHAND PHARMTECH
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