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Medicine composite for treating peripheral nerve injury

A technology of peripheral nerves and nerves, applied in the application of drugs for the treatment of peripheral nerve injuries, the field of pharmaceutical compositions for the treatment of peripheral nerve injuries, can solve problems that have not been reported yet, and achieve the promotion of axon regeneration and myelination, inhibition Death, high safety effect

Active Publication Date: 2015-02-04
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is suggested that insulin growth factor-1 may be an effective drug preparation for broad-spectrum nerve injury repair, but there are no reports on its promotion of nerve injury repair at home and abroad

Method used

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  • Medicine composite for treating peripheral nerve injury
  • Medicine composite for treating peripheral nerve injury
  • Medicine composite for treating peripheral nerve injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1: Preparation of insulin growth factor-1

[0063] Insulin growth factor-1, also known as "growth-promoting factor" (ie somatomedin C), is a polypeptide protein substance similar to insulin in molecular structure. Insulin growth factor-1 of the present invention is a kind of active protein polypeptide substance, is a single-chain basic protein with 70 amino acids, which is formed by cross-connecting three disulfide bonds, with a molecular weight of 7649Da and heat resistance; it is compatible with human Proinsulin is approximately 50% similar in structure and function. The insulin-like growth factor-1 was purchased by Sigma Biological Company of the United States (article number: MSDS I8779), and it can also be synthesized by genetic recombination. For details, see: (Huang Lihui, Zhu Yuding CN98106111.7 Construction of insulin-like growth factor-1 engineering bacteria and Method for preparing insulin-like growth factor-1; CN200410053399.6 Zhu Chenggang, Wang...

Embodiment 2

[0064] Embodiment 2: the preparation of pharmaceutical composition

[0065] Medical chitosan gel (Shanghai Qisheng Biological Preparations Co., Ltd.) plus insulin growth factor-1 group: After injecting 10 μl of medical chitosan gel into the tube, 5 μl of insulin growth factor-1 (2 ng / μl , 20ng / μl, 200ng / μl American Sigma Company) into sterile medical silicone tube. In addition to using the above methods to ensure the long-lasting and slow local action of the active ingredients of the drug, traditional needle local injection and smearing methods can also be used to act on the injured nerve. Different methods have the effect of improving peripheral nerve injury.

[0066] Prove the beneficial effect of the present invention by concrete pharmacodynamic experiment below.

Embodiment 3

[0067] Example 3: Observation of Insulin Growth Factor-1 on the General State of Rat Peripheral Nerve Injury

[0068] 210 SD rats, male or female, body weight 210±26g, were divided into 20 rats in the sham operation group (exposed nerve only), 20 rats in the neurotomy plus silicone tube plus chitosan group, chitosose plus insulin growth factor- 1 (10ng / kg) 40 rats, chitosan plus insulin growth factor-1 (100ng / kg) 40 rats, chitosan plus insulin growth factor-1 (1000ng / kg) 40 rats; each group is further divided into: 1 , 2, 3, and 4 week time points.

[0069] Methods: 1% sodium pentobarbital was injected intraperitoneally at 30 mg / kg for anesthesia. In the lateral position, after shaving and disinfection, the femur was taken through a posterior oblique incision to expose the right sciatic nerve. The sciatic nerve was dissected under a 10X operating microscope, and the sciatic nerve was resected about 8 mm below the exit of the piriformis muscle by about 8 mm, and allowed to ret...

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Abstract

The invention relates to application of insulin-like growth factor-1 on preparation of medicaments for treating peripheral nerve injury and a medicine composite for treating the peripheral nerve injury. An active ingredient of the medicine composite is the insulin-like growth factor-1. The medicine composite has functions of promoting proliferation and survival of schwann cells, restraining cell death, participating in neuron protection, cynapse rebuilding after injury, restraining denervation sweeny and the like, can directly and effectively improve serious peripheral nerve injury, and is accurate in pesticide effect and high in safety.

Description

technical field [0001] The present invention relates to a new application of insulin growth factor-1 (IGF-1), in particular to the application of insulin growth factor-1 in the preparation of medicines for treating peripheral nerve injury, and the present invention further provides a method for treating peripheral nerve injury Damaged pharmaceutical composition. Background technique [0002] The regeneration and repair of peripheral nerve injury has always been a concern of neuroscientists and clinicians. Peripheral nerves include 31 pairs of spinal nerves and 12 pairs of cranial nerves. Peripheral nerve injury is a multiple disease, and peripheral nerve injury may occur in traffic accidents, natural disasters, and even during the clinical treatment of other diseases. It is manifested as pathological changes of peripheral nerves caused by various factors, as well as dysfunction of the skin, muscles, sports, blood vessels and other functions innervated by them. Peripheral n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/30A61P25/02
Inventor 高洁伍亚民曾玲陈瑶陈灿
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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